Microbiom and Dermatology

Abstract

Microbiome is a term defi ning the microbes, their genome and the environment which they belong to. Skin is one of the body sites as well as nasal, oral, gastrointestinal and urogenital areas which had been focused to be studied as a part of human genome project. Skin is an ecosystem containing microbial communities living in various physiologic and topographic conditions such as sebaceous/non-sebaceous, hairy/glabrous, moist/dry, wrinkled/plain areas. Skin microbiome is under investigation also in dermatological disorders as atopic dermatitis, acne, psoriasis and diabetic wounds beside healthy individuals with 16SrRNA sequencing studies. Findings of these investigations are reviewed in this article.

Keywords

• Human microbioma project,skin microbiome

Mikrobiyom ve Dermatoloji

Abstract

Mikrobiyom, mikropları, genomlarını ve ait oldukları çevreyi tanımlayan bir terimdir. İnsan mikrobiyom projesi içinde deri de nazal, oral, gastrointestinal ve ürogenital bölgelerin yanında mikrobiyomunun çalışılması için seçilen bölgelerdendir. Deri, yağlı/yağsız, kıllı/kılsız, nemli/kuru, katlantılı/pürüzsüz bölgeler gibi fizyolojik ve topografik olarak farklı koşullarda yaşayan mikrobiyal toplulukları içeren bir ekosistemdir. 16S rRNA dizileme çalışmaları ile sağlıklı bireylerin yanında değişik hastalık gruplarında da deri mikrobiyomu incelenmiştir. Atopik dermatit, akne, psoriyazis ve diyabetik yaralar mikrobiyom çalışmalarının çoğunun yapılmakta olduğu dermatolojik hastalıklardır. Bu derlemede deri mikrobiyomuyla ilgili çalışmaların bulguları özetlenmiştir.

Keywords

• İnsan mikrobiyom projesi,deri mikrobiyomu

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