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Sweeteners, Glucose Intolerance and Microbiota

Year 2017, - Mikrobiyota, 34 - 38, 15.11.2017

Abstract

The use of food additives in food production are inevitable in this modern world. Although only safe amount of them are approved, their safety have always been questioned. The effects of food additives on microbiota have not been investigated in detailed manner up to know. In this review the effects of sweeteners, a part of food additives, were reviewed and showed that they affect microbiota. As a rusult, nonnutritive syntetic sweeteners can lead to glucose intolerance by affecting microbiota and a part of sugar alcohols show probiotic like effects.

References

  • 1. Jin Y, Wu S, Zeng Z, Fu Z. Effects of environmental pollutants on gut microbiota. Environ Pollut. 2017; 222: 1-9.
  • 2. Gültekin F. A'dan Z'ye Gıda Katkı Maddeleri. Server İletişim, 2014, İstanbul.
  • 3. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C.A, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artifi cial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514: 181-186.
  • 4. Palmnäs MS, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel HJ, Hittel DS, Shearer J. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One. 2014; 14: 9(10)
  • 5. Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet PM. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015; 25(10): 736-42
  • 6. Daly K, Darby AC, Hall N, Nau A, Bravo D, Shirazi-Beechey SP. Dietary supplementation with lactose or artifi cial sweetener enhances swine gut Lactobacillus population abundance. Br J Nutr. 2014; 111 Suppl 1: 30-5
  • 7. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microfl ora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats, J Toxicol Environ Health A. 2008; 71(21): 1415–1429.
  • 8. Beards E, Tuohy K, Gibson G. A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition. Br J Nutr. 2010 Sep;104(5):701-8. doi: 10.1017/ S0007114510001078. Epub 2010 Apr 7.
  • 9. Thabuis C, Herbomez AC, Desailly F, Florence R, Wils D, GuérinDeremaux L. Prebiotic like effects of Sweet Pearle maltitol through changes in caecal and fecal parameters. Food Nutr Sci. 2012; 3: 1375-1381.
  • 10. Oku T, Akiba M, Lee MH, Moon SJ, Hosoya N. Metabolic fate of ingested [14C]-maltitol in man. J Nutr Sci Vitaminol. 1991; 37: 529–544.
  • 11. Lynch H, Milgrom P, “Xylitol and dental caries: an overview for clinicians”, J Calif Dent Assoc, 2003, 31(3), 205-209.
  • 12. Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino S, Lingström P, “Six months of daily high-dose xylitol in highrisk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci”, Caries Res, 2009, 43(6), 455-461.
  • 13. Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V. Gut microfl ora interactions with xylitol in the mouse, rat and man. Food Chem Toxicol. 1985; 23: 985–990.
  • 14. Tamura M, Hoshi C, Hori S. Xylitol affects the intestinal microbiota and metabolism of daidzein in adult male mice. Int J Mol Sci. 2013;14: 23993-24007.
  • 15. Yebra MJ, Perez-Martinez G. Cross-talk between the L-sorbose and D-sorbitol (D-glucitol) metabolic pathways in Lactobacillus casei. Microbiology. 2002; 148:2351-2359.
  • 16. Rhodes MW, Kator, H. Sorbitol-fermenting bifi dobacteria as indicators of diffuse human faecal pollution in estuarine watersheds. J Appl Microbiol. 1999; 87: 528-535.
  • 17. Farnworth ER. In:Wildman REC (Ed.), Handbook of Nutraceutilcals and Functional Foods. 2001; 407 - 422. Boca Raton, FL: CRC Press.
  • 18. Salminen S, Salminen E, Bridges J, Marks V. The effects of sorbitol on the gastrointestinal microfl ora in rats. Z Ernahrungswiss. 1986; 25: 91-95.
  • 19. Sarmiento-Rubiano LA, Zúñiga M, Pérez-Martínez G, Yebra MJ. Dietary supplementation with sorbitol results in selective enrichment of lactobacilli in rat intestine. Res Microbiol. 2007; 158(8-9): 694-701.
  • 20. Goossens J, Röper H. Erythritol: a new sweetener. Food Sci Technol Today. 1994; 8: 144–149.
  • 21. Bernt WO, Borzelleca JF, Flamm G, Munro IC. Erythritol: A review of biological and toxicological studies. Regul Toxicol Pharmacol. 1996; 24: 191–197.
  • 22. Bornet FRJ, Blayo A, Dauchy F, Slama G. Plasma and urine kinetics of erythritol after oral ingestion by healthy humans. Regul Toxicol Pharmacol. 1996; 24: 280–285.
  • 23. Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N, Modderman J. Effects of oral administration of erythritol on patients with diabetes. Regul Toxicol Pharmacol. 1996; 24: 303–308.
  • 24. Noda K, Oku T. Metabolism and deposition of erythritol after oral administration to rats. J Nutr. 1992; 122: 1266–1272.
  • 25. Arrigoni E, Brouns F, Amadò R. Human gut microbiota does not ferment erythritol. Br J Nutr. 2005; 94: 643–646.

Tatlandırıcılar, Glikoz İntoleransı ve Mikrobiyota

Year 2017, - Mikrobiyota, 34 - 38, 15.11.2017

Abstract

Gıda katkı maddelerinin günümüz dünyasında kullanılması kaçınılmaz hale gelmiştir. Her ne kadar sadece güvenli miktarların gıdalarda kullanılmasına izin verilse de katkı maddelerinin güvenilirliği sürekli sorgulanmaktadır. Katkı maddelerinin mikrobiyotaya etkileri ise oldukça az çalışılmış bir konudur. Katkı maddelerinin bir kısmını oluşturan tatlandırıcıların etkisini incelediğimiz bu derlemede, tatlandırıcıların mikrobiyotayı etkiledikleri, bu etki sonucu sentetik olanların glikoz intoleransına yol açtıkları, şeker alkollerinin ise bir kısmının prebiyotik benzeri olumlu bir etki gösterdiği anlaşılmaktadır.

References

  • 1. Jin Y, Wu S, Zeng Z, Fu Z. Effects of environmental pollutants on gut microbiota. Environ Pollut. 2017; 222: 1-9.
  • 2. Gültekin F. A'dan Z'ye Gıda Katkı Maddeleri. Server İletişim, 2014, İstanbul.
  • 3. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C.A, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artifi cial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514: 181-186.
  • 4. Palmnäs MS, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel HJ, Hittel DS, Shearer J. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One. 2014; 14: 9(10)
  • 5. Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet PM. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015; 25(10): 736-42
  • 6. Daly K, Darby AC, Hall N, Nau A, Bravo D, Shirazi-Beechey SP. Dietary supplementation with lactose or artifi cial sweetener enhances swine gut Lactobacillus population abundance. Br J Nutr. 2014; 111 Suppl 1: 30-5
  • 7. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microfl ora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats, J Toxicol Environ Health A. 2008; 71(21): 1415–1429.
  • 8. Beards E, Tuohy K, Gibson G. A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition. Br J Nutr. 2010 Sep;104(5):701-8. doi: 10.1017/ S0007114510001078. Epub 2010 Apr 7.
  • 9. Thabuis C, Herbomez AC, Desailly F, Florence R, Wils D, GuérinDeremaux L. Prebiotic like effects of Sweet Pearle maltitol through changes in caecal and fecal parameters. Food Nutr Sci. 2012; 3: 1375-1381.
  • 10. Oku T, Akiba M, Lee MH, Moon SJ, Hosoya N. Metabolic fate of ingested [14C]-maltitol in man. J Nutr Sci Vitaminol. 1991; 37: 529–544.
  • 11. Lynch H, Milgrom P, “Xylitol and dental caries: an overview for clinicians”, J Calif Dent Assoc, 2003, 31(3), 205-209.
  • 12. Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino S, Lingström P, “Six months of daily high-dose xylitol in highrisk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci”, Caries Res, 2009, 43(6), 455-461.
  • 13. Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V. Gut microfl ora interactions with xylitol in the mouse, rat and man. Food Chem Toxicol. 1985; 23: 985–990.
  • 14. Tamura M, Hoshi C, Hori S. Xylitol affects the intestinal microbiota and metabolism of daidzein in adult male mice. Int J Mol Sci. 2013;14: 23993-24007.
  • 15. Yebra MJ, Perez-Martinez G. Cross-talk between the L-sorbose and D-sorbitol (D-glucitol) metabolic pathways in Lactobacillus casei. Microbiology. 2002; 148:2351-2359.
  • 16. Rhodes MW, Kator, H. Sorbitol-fermenting bifi dobacteria as indicators of diffuse human faecal pollution in estuarine watersheds. J Appl Microbiol. 1999; 87: 528-535.
  • 17. Farnworth ER. In:Wildman REC (Ed.), Handbook of Nutraceutilcals and Functional Foods. 2001; 407 - 422. Boca Raton, FL: CRC Press.
  • 18. Salminen S, Salminen E, Bridges J, Marks V. The effects of sorbitol on the gastrointestinal microfl ora in rats. Z Ernahrungswiss. 1986; 25: 91-95.
  • 19. Sarmiento-Rubiano LA, Zúñiga M, Pérez-Martínez G, Yebra MJ. Dietary supplementation with sorbitol results in selective enrichment of lactobacilli in rat intestine. Res Microbiol. 2007; 158(8-9): 694-701.
  • 20. Goossens J, Röper H. Erythritol: a new sweetener. Food Sci Technol Today. 1994; 8: 144–149.
  • 21. Bernt WO, Borzelleca JF, Flamm G, Munro IC. Erythritol: A review of biological and toxicological studies. Regul Toxicol Pharmacol. 1996; 24: 191–197.
  • 22. Bornet FRJ, Blayo A, Dauchy F, Slama G. Plasma and urine kinetics of erythritol after oral ingestion by healthy humans. Regul Toxicol Pharmacol. 1996; 24: 280–285.
  • 23. Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N, Modderman J. Effects of oral administration of erythritol on patients with diabetes. Regul Toxicol Pharmacol. 1996; 24: 303–308.
  • 24. Noda K, Oku T. Metabolism and deposition of erythritol after oral administration to rats. J Nutr. 1992; 122: 1266–1272.
  • 25. Arrigoni E, Brouns F, Amadò R. Human gut microbiota does not ferment erythritol. Br J Nutr. 2005; 94: 643–646.
There are 25 citations in total.

Details

Subjects Health Care Administration
Journal Section Review
Authors

Fatih Gültekin

Manolya Eser Öner This is me

Hasan Basri Savaş This is me

Bora Doğan This is me

Publication Date November 15, 2017
Acceptance Date September 11, 2017
Published in Issue Year 2017 - Mikrobiyota

Cite

AMA Gültekin F, Eser Öner M, Savaş HB, Doğan B. Sweeteners, Glucose Intolerance and Microbiota. J Biotechnol and Strategic Health Res. November 2017;1:34-38.

Journal of Biotechnology and Strategic Health Research