RADIOTHERAPY AND IMMMUN RESPONCE IS THE RADIOTHERAPY VACCINE? GOOD NEWS?

Year 2019, Volume: 6 Issue: 3, 199 - 204, 30.09.2019

Cengiz Kurtman

https://doi.org/10.34087/cbusbed.461425

Cited By: 1

Abstract

SUMMARY/ABSTRACT: Radiotherapy (RT) activates
immun responce.
Because of this we must discuss the question of “is the radiotherapy vaccine”. If
RT increases the immun responce we must learn some more about the RT effects on
the cells, cell surface antigene, immun checkpoints and their inhibition (ICI;
CTLA4, PD1, PDL1 inhibition). In
this review it will be discussed the role of the radiotherapy and biologic
effects of the radiotherapy to activate the immun responce, radiotherapy dose,
radiotherapy timing and the side effects of immun checkpoints inhibitors.

RADYOTERAPİ VE İMMUN YANIT RADYOTERAPİ AŞIMIDIR? İYİ HABER?

Abstract

ÖZET: Radyoterapi
(RT) immün yanıtı aktive etmektedir. Bundan dolayı “radyoterapi aşımıdır”
sorusunu tartışmak gerekmektedir. RT, immün yanıtı artırıyorsa, hücrelerdeki RT
etkileri, hücre yüzeyi antijeni, immün kontrol noktaları ve bunların
inhibisyonu hakkında daha fazla bilgi edinmeliyiz (ICI; CTLA4, PD1, PDL1
inhibisyonu). Bu derlemede, radyoterapinin ve biyolojik etkilerinin immun
cevabı aktive etmede ki rolü, radyoterapi dozu, radyoterapi zamanlaması ve immun
kontrol noktaları baskılayıcılarının yan etkileri tartışılacaktır.

Keywords

Radyoterapi, immun yanıt, immun kontrol noktaları

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