Research Article
BibTex RIS Cite

Vitiligo ile Serum 25(OH) D Vitamini İlişkisi

Year 2021, Volume: 8 Issue: 2, 250 - 253, 30.06.2021
https://doi.org/10.34087/cbusbed.797721

Abstract

Giriş ve Amaç: Vitiligo hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile vitiligo arasında olası bir ilişki olup olmadığı belirlemektir.
Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında vitiligo tanısı konulan 45 hasta ve 83 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi.Ayrıca serum paratiroid hormon kalsiyum, fosfor, alkalen fosfataz seviyeleri de incelendi.
Bulgular: Çalışmamıza 9-55 yaş(ort 28,22 ± 7,1 ) arasındaki 45 hasta ve kontrol grubunda 18-58 yaş arası(ortalama: 34,38 ± 7.3) 83 sağlıklı birey katılmıştır.Vitiligolu hastalarda serum 25 (OH) D seviyeleri ortalama 22,19 ng / ml (8,42-80,1 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 23,4 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05).
Sonuç: Bu sonuçlar ışığında serum 25(OH) D vitamini ile vitiligo arasında herhangi bir ilişki bulunmamıştır.

References

  • Utas, S ,Sendur, N, Aydıngöz, I, et al., An epidemiologic study of Turkey: Vitiligo in childhood, Pediatric Dermatology, 2004, 21(3), 413.
  • Kriegel, M.A, Manson, J.E, Costenbader, K.H, Does vitamin D affect risk of developing autoimmune disease? A systematic review, Seminars in Arthritis Rheumatism, 2011, 40, 512–531.
  • Hewison, M, Vitamin D and the immune system: new perspectives on an old theme, Endocrinology Metabolism Clinics of North America, 2010, 39, 365–379.
  • LoPiccolo, M.C, Lim, H.W, Vitamin D in health and disease, Photodermatology Photoimmunology Photomedicine, 2010, 26, 224–229.
  • Agmon-Levin, N, Shoenfeld, Y. Prediction and prevention of autoimmune skin disorder, Archives of Dermatological Research, 2009, 301, 57–64.
  • Bergler-Czop, B, Brzezińska-Wcisło, L, Serum vitamin D level – the effect on the clinical course of psoriasis, Advances in Dermatology and Allergology, 2016, 33, 445–449.
  • Karagün, E, Ergin, C, Baysak, S, et al., The role of serum vitamin D levels in vitiligo, Advances in Dermatology and Allergology, 2016, 33, 300–302.
  • Kucharska, A, Szmurło, A, Sińska, B, Significance of diet in treated and untreated acne vulgaris, Advances in Dermatology and Allergology, 2016, 33, 81–86.
  • Amano, H, Abe, M, Ishikawa, O, First case report of topical tacalcitol for vitiligo repigmentation, Pediatric Dermatology, 2008, 25, 262–264.
  • Lips, P, Hosking, D, Lippuner, K, et al, The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation, Journal of Internal Medicine, 2006, 260, 245–254.
  • Saleh, H.M.A, Abdel Fattah, N.S.A, Hamza, H.T.M.M, Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases, Photodermatology Photoimmunology Photomedicine, 2013, 29, 34-40.
  • Upala, S, Sanguankea, A, Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis, Photodermatology Photoimmunology Photomedicine, 2016, 32, 181-190.
  • Zhang, J.Z, Wang, M, Ding, Y, Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo:A meta-analysis, Medicine(Baltimore), 2018, 97, e11506.
  • Hekimsoy, Z, Dinç, G, Kafesçiler, S, et al., Vitamin D status among adults in the Aegean region of Turkey, BMC Public Health, 2010, 10, 782.
  • Orun, E, Sezer, S, Kanburoglu, M.K, et al., Vitamin D deficiency in healthy children and adolescent, Clinical and Investigative Medicine, 2015, 38, E261–266.
  • Van der Meer, I.M, Middelkoop, B.J, Boeke, A.J, Lips, P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview, Osteoporos International, 2011, 22, 1009–1021.
  • Holick, M.F, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease, American Journal of Clinical Nutrition, 2004, 80(6 Suppl), 1678S–88S.
  • Gannagé-Yared, M.H, Chemali, R, Yaacoub, N, et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers, Journal of Bone and Mineral Research, 2000, 15, 1856–1862.
  • Mishal, A.A, Effects of different dress styles on vitamin D levels in healthy young Jordanian women, Osteoporos International, 2001, 12, 931–935.
  • Lips, P, Vitamin D status and nutrition in Europe and Asia, Journal of Steroid Biochemistry and Molecular Biology, 2007, 103, 620–625.

Association Between 25(OH) Vitamin D and vitiligo

Year 2021, Volume: 8 Issue: 2, 250 - 253, 30.06.2021
https://doi.org/10.34087/cbusbed.797721

Abstract

Objective: To evaluate serum 25-hydroxyvitamin D (25 (OH) D) levels in vitiligo patients and to determine whether there is a possible relationship between serum 25 (OH) D levels and vitiligo by comparing it with a control group of healthy individuals.
Material and Methods: 45 patients and 83 healthy individuals diagnosed with vitiligo between October 2017 and March 2018 were included in the study. Serum vitamin D levels of the study group were evaluated by high performance liquid chromatography method. Serum parathyroid hormone calcium, phosphorus, alkaline phosphatase levels were also examined.
Results: 45 patients between 9-55 years old (mean 28.22 ± 7.1) and 83 healthy individuals between 18-58 years old (mean: 34.38 ± 7.3) in the control group participated in our study. Serum 25 (OH) D levels were determined as an average of 22.19 ng / ml (8.42-80.1 ng / ml) in patients with vitiligo. In the control group, serum 25 (OH) D levels were determined to be 23.4 ng / ml (3-69.2 ng / ml). There was no statistically significant difference between the serum vitamin D levels between the two groups (p> 0.05 ).
Conclusion: In the light of these results, no relationship was found between vitiligo and serum 25 (OH) vitamin D.

References

  • Utas, S ,Sendur, N, Aydıngöz, I, et al., An epidemiologic study of Turkey: Vitiligo in childhood, Pediatric Dermatology, 2004, 21(3), 413.
  • Kriegel, M.A, Manson, J.E, Costenbader, K.H, Does vitamin D affect risk of developing autoimmune disease? A systematic review, Seminars in Arthritis Rheumatism, 2011, 40, 512–531.
  • Hewison, M, Vitamin D and the immune system: new perspectives on an old theme, Endocrinology Metabolism Clinics of North America, 2010, 39, 365–379.
  • LoPiccolo, M.C, Lim, H.W, Vitamin D in health and disease, Photodermatology Photoimmunology Photomedicine, 2010, 26, 224–229.
  • Agmon-Levin, N, Shoenfeld, Y. Prediction and prevention of autoimmune skin disorder, Archives of Dermatological Research, 2009, 301, 57–64.
  • Bergler-Czop, B, Brzezińska-Wcisło, L, Serum vitamin D level – the effect on the clinical course of psoriasis, Advances in Dermatology and Allergology, 2016, 33, 445–449.
  • Karagün, E, Ergin, C, Baysak, S, et al., The role of serum vitamin D levels in vitiligo, Advances in Dermatology and Allergology, 2016, 33, 300–302.
  • Kucharska, A, Szmurło, A, Sińska, B, Significance of diet in treated and untreated acne vulgaris, Advances in Dermatology and Allergology, 2016, 33, 81–86.
  • Amano, H, Abe, M, Ishikawa, O, First case report of topical tacalcitol for vitiligo repigmentation, Pediatric Dermatology, 2008, 25, 262–264.
  • Lips, P, Hosking, D, Lippuner, K, et al, The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation, Journal of Internal Medicine, 2006, 260, 245–254.
  • Saleh, H.M.A, Abdel Fattah, N.S.A, Hamza, H.T.M.M, Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases, Photodermatology Photoimmunology Photomedicine, 2013, 29, 34-40.
  • Upala, S, Sanguankea, A, Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis, Photodermatology Photoimmunology Photomedicine, 2016, 32, 181-190.
  • Zhang, J.Z, Wang, M, Ding, Y, Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo:A meta-analysis, Medicine(Baltimore), 2018, 97, e11506.
  • Hekimsoy, Z, Dinç, G, Kafesçiler, S, et al., Vitamin D status among adults in the Aegean region of Turkey, BMC Public Health, 2010, 10, 782.
  • Orun, E, Sezer, S, Kanburoglu, M.K, et al., Vitamin D deficiency in healthy children and adolescent, Clinical and Investigative Medicine, 2015, 38, E261–266.
  • Van der Meer, I.M, Middelkoop, B.J, Boeke, A.J, Lips, P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview, Osteoporos International, 2011, 22, 1009–1021.
  • Holick, M.F, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease, American Journal of Clinical Nutrition, 2004, 80(6 Suppl), 1678S–88S.
  • Gannagé-Yared, M.H, Chemali, R, Yaacoub, N, et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers, Journal of Bone and Mineral Research, 2000, 15, 1856–1862.
  • Mishal, A.A, Effects of different dress styles on vitamin D levels in healthy young Jordanian women, Osteoporos International, 2001, 12, 931–935.
  • Lips, P, Vitamin D status and nutrition in Europe and Asia, Journal of Steroid Biochemistry and Molecular Biology, 2007, 103, 620–625.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Dermatology
Journal Section Araştırma Makalesi
Authors

Erdinç Terzi 0000-0002-5507-7326

Publication Date June 30, 2021
Published in Issue Year 2021 Volume: 8 Issue: 2

Cite

APA Terzi, E. (2021). Vitiligo ile Serum 25(OH) D Vitamini İlişkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 8(2), 250-253. https://doi.org/10.34087/cbusbed.797721
AMA Terzi E. Vitiligo ile Serum 25(OH) D Vitamini İlişkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. June 2021;8(2):250-253. doi:10.34087/cbusbed.797721
Chicago Terzi, Erdinç. “Vitiligo Ile Serum 25(OH) D Vitamini İlişkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8, no. 2 (June 2021): 250-53. https://doi.org/10.34087/cbusbed.797721.
EndNote Terzi E (June 1, 2021) Vitiligo ile Serum 25(OH) D Vitamini İlişkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8 2 250–253.
IEEE E. Terzi, “Vitiligo ile Serum 25(OH) D Vitamini İlişkisi”, CBU-SBED: Celal Bayar University-Health Sciences Institute Journal, vol. 8, no. 2, pp. 250–253, 2021, doi: 10.34087/cbusbed.797721.
ISNAD Terzi, Erdinç. “Vitiligo Ile Serum 25(OH) D Vitamini İlişkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 8/2 (June 2021), 250-253. https://doi.org/10.34087/cbusbed.797721.
JAMA Terzi E. Vitiligo ile Serum 25(OH) D Vitamini İlişkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2021;8:250–253.
MLA Terzi, Erdinç. “Vitiligo Ile Serum 25(OH) D Vitamini İlişkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 8, no. 2, 2021, pp. 250-3, doi:10.34087/cbusbed.797721.
Vancouver Terzi E. Vitiligo ile Serum 25(OH) D Vitamini İlişkisi. CBU-SBED: Celal Bayar University-Health Sciences Institute Journal. 2021;8(2):250-3.