Vitiligo ile Serum 25(OH) D Vitamini İlişkisi

Yıl 2021, Cilt: 8 Sayı: 2, 250 - 253, 30.06.2021

Erdinç Terzi

https://doi.org/10.34087/cbusbed.797721

Öz

Giriş ve Amaç: Vitiligo hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile vitiligo arasında olası bir ilişki olup olmadığı belirlemektir.
Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında vitiligo tanısı konulan 45 hasta ve 83 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi.Ayrıca serum paratiroid hormon kalsiyum, fosfor, alkalen fosfataz seviyeleri de incelendi.
Bulgular: Çalışmamıza 9-55 yaş(ort 28,22 ± 7,1 ) arasındaki 45 hasta ve kontrol grubunda 18-58 yaş arası(ortalama: 34,38 ± 7.3) 83 sağlıklı birey katılmıştır.Vitiligolu hastalarda serum 25 (OH) D seviyeleri ortalama 22,19 ng / ml (8,42-80,1 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 23,4 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05).
Sonuç: Bu sonuçlar ışığında serum 25(OH) D vitamini ile vitiligo arasında herhangi bir ilişki bulunmamıştır.

Anahtar Kelimeler

D vitamini, Vitiligo, ilişkisi

Association Between 25(OH) Vitamin D and vitiligo

Öz

Objective: To evaluate serum 25-hydroxyvitamin D (25 (OH) D) levels in vitiligo patients and to determine whether there is a possible relationship between serum 25 (OH) D levels and vitiligo by comparing it with a control group of healthy individuals.
Material and Methods: 45 patients and 83 healthy individuals diagnosed with vitiligo between October 2017 and March 2018 were included in the study. Serum vitamin D levels of the study group were evaluated by high performance liquid chromatography method. Serum parathyroid hormone calcium, phosphorus, alkaline phosphatase levels were also examined.
Results: 45 patients between 9-55 years old (mean 28.22 ± 7.1) and 83 healthy individuals between 18-58 years old (mean: 34.38 ± 7.3) in the control group participated in our study. Serum 25 (OH) D levels were determined as an average of 22.19 ng / ml (8.42-80.1 ng / ml) in patients with vitiligo. In the control group, serum 25 (OH) D levels were determined to be 23.4 ng / ml (3-69.2 ng / ml). There was no statistically significant difference between the serum vitamin D levels between the two groups (p> 0.05 ).
Conclusion: In the light of these results, no relationship was found between vitiligo and serum 25 (OH) vitamin D.

Anahtar Kelimeler

Vitamin D, Vitiligo, Relationship

Kaynakça

• Utas, S ,Sendur, N, Aydıngöz, I, et al., An epidemiologic study of Turkey: Vitiligo in childhood, Pediatric Dermatology, 2004, 21(3), 413.
• Kriegel, M.A, Manson, J.E, Costenbader, K.H, Does vitamin D affect risk of developing autoimmune disease? A systematic review, Seminars in Arthritis Rheumatism, 2011, 40, 512–531.
• Hewison, M, Vitamin D and the immune system: new perspectives on an old theme, Endocrinology Metabolism Clinics of North America, 2010, 39, 365–379.
• LoPiccolo, M.C, Lim, H.W, Vitamin D in health and disease, Photodermatology Photoimmunology Photomedicine, 2010, 26, 224–229.
• Agmon-Levin, N, Shoenfeld, Y. Prediction and prevention of autoimmune skin disorder, Archives of Dermatological Research, 2009, 301, 57–64.
• Bergler-Czop, B, Brzezińska-Wcisło, L, Serum vitamin D level – the effect on the clinical course of psoriasis, Advances in Dermatology and Allergology, 2016, 33, 445–449.
• Karagün, E, Ergin, C, Baysak, S, et al., The role of serum vitamin D levels in vitiligo, Advances in Dermatology and Allergology, 2016, 33, 300–302.
• Kucharska, A, Szmurło, A, Sińska, B, Significance of diet in treated and untreated acne vulgaris, Advances in Dermatology and Allergology, 2016, 33, 81–86.
• Amano, H, Abe, M, Ishikawa, O, First case report of topical tacalcitol for vitiligo repigmentation, Pediatric Dermatology, 2008, 25, 262–264.
• Lips, P, Hosking, D, Lippuner, K, et al, The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation, Journal of Internal Medicine, 2006, 260, 245–254.
• Saleh, H.M.A, Abdel Fattah, N.S.A, Hamza, H.T.M.M, Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases, Photodermatology Photoimmunology Photomedicine, 2013, 29, 34-40.
• Upala, S, Sanguankea, A, Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis, Photodermatology Photoimmunology Photomedicine, 2016, 32, 181-190.
• Zhang, J.Z, Wang, M, Ding, Y, Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo:A meta-analysis, Medicine(Baltimore), 2018, 97, e11506.
• Hekimsoy, Z, Dinç, G, Kafesçiler, S, et al., Vitamin D status among adults in the Aegean region of Turkey, BMC Public Health, 2010, 10, 782.
• Orun, E, Sezer, S, Kanburoglu, M.K, et al., Vitamin D deficiency in healthy children and adolescent, Clinical and Investigative Medicine, 2015, 38, E261–266.
• Van der Meer, I.M, Middelkoop, B.J, Boeke, A.J, Lips, P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview, Osteoporos International, 2011, 22, 1009–1021.
• Holick, M.F, Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease, American Journal of Clinical Nutrition, 2004, 80(6 Suppl), 1678S–88S.
• Gannagé-Yared, M.H, Chemali, R, Yaacoub, N, et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers, Journal of Bone and Mineral Research, 2000, 15, 1856–1862.
• Mishal, A.A, Effects of different dress styles on vitamin D levels in healthy young Jordanian women, Osteoporos International, 2001, 12, 931–935.
• Lips, P, Vitamin D status and nutrition in Europe and Asia, Journal of Steroid Biochemistry and Molecular Biology, 2007, 103, 620–625.