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Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi

Yıl 2025, Cilt: 12 Sayı: 2, 289 - 295, 27.06.2025
https://doi.org/10.34087/cbusbed.1643518

Öz

ÖZ
Giriş ve Amaç: Aralık 2019’da Çin’in Wuhan kentinde başlayan SARS-CoV2 tip COVİD-19 hastalığı kısa sürede bütün dünyaya yayılıp pandemi halini almıştır. COVID-19 hastalığı vasküler yapıları etkileyerek damar tıkanıklığına bağlı gelişen miyokard enfarktüsü, iskemik serebrovasküler hastalık (SVH), venöz dolaşım bozukluğu gibi hastalıklara yol açmaktadır. Amacımız acil servise başvuran non-travmatik SVH tanılı hastaların COVID-19 hastalığı ile ilişkisini araştırmaktır.
Gereç ve Yöntemler: Retrospektif olarak yapılan çalışmaya pandemi öncesi 10 Mart 2019 – 10 Mart 2020 tarihleri arasında, pandemi döneminde de 11 Mart 2020 - 11 Mart 2021 tarihleri arasında başvuran, görüntüleme ile SVH tanısı koyulan ya da klinik olarak geçici iskemik atak (GİA) düşünülen 18 yaş üstü erişkin hastalar dahil edilmiştir.
Bulgular: Çalışmaya dahil edilen 435 olgunun 211’i (%48,51) pandemi öncesi, 224’ü (%51,49) ise pandemi döneminde olup her iki dönemde de erkek cinsiyet hakimiyeti vardır. Pandemi öncesi 211 olgunun 174’ü (%82,5), pandemi dönemi ise 224 olgunun 186’sı (%83) iskemik SVH tanısı almıştır.
Sonuç: COVID-19 hastalığının özellikle kronik hastalığı olanlarda vasküler yapıları etkileyerek hiperkoagülopatiye yol açtığı buna bağlı olarak içinde SVH’ın da olduğu çeşitli hastalıklara neden olduğu tespit edilmiştir. COVID-19 hastalığı ile SVH arasındaki ilişkinin bilinmesi ve oluş mekanizmalarının araştırılması; bu hastalara erken tanı konulması ve hastalık ortaya çıkmadan gerekli önlemler (antikoagülan vb.) alınmasıyla COVID-19 hastalarında morbidite ve mortalitenin azaltılması adına önemli olabilir.
Anahtar Kelimeler: Covid-19, stroke, serebrovasküler hastalık, pandemi

Kaynakça

  • 1. de Wilde AH, Snijder EJ, ve ark. Host Factors in Coronavirus Replication. Curr Top Microbiol Immunol. 2018;419:1-42
  • 2. World Health Organization 2020; https://www.who.int/emergencies/diseases/novel-coronavirus-2019 Reached on 06.12.2022.
  • 3. Pelisek, J., Reutersberg, B., ve ark. (2022). Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs. Clinical Science, 136(21), 1571-1590.
  • 4. Payus, AO., Lin, CLS., ve ark. (2020). SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). Bosnian journal of basic medical sciences, 20(3), 283.
  • 5. Markus, H. S., & Brainin, M. (2020). COVID-19 and stroke—A global World Stroke Organization perspective. International journal of stroke, 15(4), 361-364.
  • 6. Oğuzhan Çoban EE. BEYİN DAMAR HASTALIKLARINDA TANIMLAR, SINIFLAMA, EPİDEMİYOLOJİ VE RİSK FAKTÖRLERİ. In: A. Emre Öge BB, Başar Bilgiç (eds). İTF Nöroloji, e-kitap2019.
  • 7. Owolabi, MO., Thrift, AG., ve ark. (2022). Primary stroke prevention worldwide: translating evidence into action. The Lancet Public Health, 7(1), e74-e85.
  • 8. https://covid19.who.int/ access:21.03.2023
  • 9. Shakil, SS., Emmons-Bell, ve ark. (2022). Stroke among patients hospitalized with COVID-19: results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Stroke, 53(3), 800-807.
  • 10. Pellegrini, L., Albecka, A., ve ark. (2020). SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids. Cell stem cell, 27(6), 951-961.
  • 11. Akhtar, N., Abid, FB., ve ark. (2021). Characteristics and comparison of 32 COVID-19 and non-COVID-19 ischemic strokes and historical stroke patients. Journal of Stroke and Cerebrovascular Diseases, 30(1), 105435.
  • 12. Cenko, E., Badimon, L., ve ark. (2021). Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on thrombosis and the association for acute CardioVascular care (ACVC), in collaboration with the European heart rhythm association (EHRA). Cardiovascular research, 117(14), 2705-2729.
  • 13. Qureshi AI, Abd-Allah F, ve ark. Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel. Int J Stroke. 2020;15(5):540-54.
  • 14. Li Y, Li M, ve ark. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5(3):279-84.
  • 15. Hakbilir O, Çete Y, ve ark. İnme popülasyonun demografik özellikleri ve Gügeç acil servis başvurularının yeni tedavi yaklaşımları üzerine etkisi. Türkiye Acil Tıp Dergisi 2006;6:132–8.
  • 16. Şengün İ. Ş, Kutluk K, ve ark. Atrial fibrilasyonlu iskemik inme hastalarında inme alt tipleri ve diğer risk faktörleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 2004;18:133–9.
  • 17. Navarrete-Navarro P, Rivera-Fernandez R, ve ark. Outcome prediction in terms of functional disability and mortality at 1 year among ICU-admitted severe stroke patients: a prospective epidemiological study in the south of the European Union (Evascan Project, Andalusia, Spain). Intensive Care Med 2003;29:1237–44.
  • 18. Qureshi, AI., Baskett, WI., ve ark. (2021). Acute ischemic stroke and COVID-19: an analysis of 27 676 patients. Stroke, 52(3), 905-912.
  • 19. Seners P, Ben Hassen W, ve ark. Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone. JAMA Neurol. 2021;78(3):321-8.
  • 20. Yilmaz M. Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Experiences of a Tertiary Hospital in Turkey. diclemedj. March 2021;48(1):55-64. doi:10.5798/dicletip.887410
  • 21. Shi, C., Wang, L., ve ark. (2021). Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis. BMC infectious diseases, 21, 1-15.
  • 22. Danics, K., Pesti, A., ve ark. (2021). A COVID-19-association-dependent categorization of death causes in 100 autopsy cases. Geroscience, 43, 2265-2287.
  • 23. Bastug A, Bodur H, ve ark. Clinical and laboratory features of COVID-19: Predictors of severe prognosis. Int Immunopharmacol. 2020;88:106950.
  • 24. Bertsimas D, Lukin G, ve ark. COVID-19 mortality risk assessment: An international multi-center study. PLoS One. 2020;15(12):e0243262.
  • 25. Richardson S, Hirsch JS, ve ark. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-9.
  • 26. Cheng Y, Luo R, ve ark. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829-38.

The Effect Of Covıd-19 Pandemıc On Cerebrovascular Dıseases

Yıl 2025, Cilt: 12 Sayı: 2, 289 - 295, 27.06.2025
https://doi.org/10.34087/cbusbed.1643518

Öz

ABSTRACT
Aim; COVID-19 affects vascular structures and causes comorbidities such as myocardial infarction, ischemic cerebrovascular disease (CVD), and venous circulation disorder due to vascular occlusion. Our aim is to investigate the relationship between COVID-19 and non-traumatic CVD patients admitted to the emergency department.
Method; In this retrospective study, all adult patients (≥18 years old) who were diagnosed with CVD by imaging or clinically considered transient ischemic attack (TIA) between March 10, 2019 and March 10, 2020 (pre-pandemic period) and between March 11, 2020 and March 11, 2021 (pandemic period) were included.
Results; Of the 435 cases included in the study, 211 (48.51%) were in the pre-pandemic period, while 224 (51.49%) were in the pandemic period. Male gender was dominant in both periods. 174 of 211 cases (82.5%) in the pre-pandemic and 186 of 224 cases (83%) in the pandemic period were diagnosed with ischemic CVD.
Conclusion; It has been determined that COVID-19 causes hypercoagulopathy by affecting vascular structures, especially in those with chronic diseases, and results in various diseases, including CVD. To know the relationship between COVID-19 disease and CVD and to investigate the mechanisms of its occurrence, it may be important to reduce morbidity and mortality in COVID-19 patients by early diagnosis of these patients and taking the necessary precautions (anticoagulants, etc.).
Keywords: COVID-19; stroke; cerebrovascular disease; pandemic

Kaynakça

  • 1. de Wilde AH, Snijder EJ, ve ark. Host Factors in Coronavirus Replication. Curr Top Microbiol Immunol. 2018;419:1-42
  • 2. World Health Organization 2020; https://www.who.int/emergencies/diseases/novel-coronavirus-2019 Reached on 06.12.2022.
  • 3. Pelisek, J., Reutersberg, B., ve ark. (2022). Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs. Clinical Science, 136(21), 1571-1590.
  • 4. Payus, AO., Lin, CLS., ve ark. (2020). SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease-(COVID-19). Bosnian journal of basic medical sciences, 20(3), 283.
  • 5. Markus, H. S., & Brainin, M. (2020). COVID-19 and stroke—A global World Stroke Organization perspective. International journal of stroke, 15(4), 361-364.
  • 6. Oğuzhan Çoban EE. BEYİN DAMAR HASTALIKLARINDA TANIMLAR, SINIFLAMA, EPİDEMİYOLOJİ VE RİSK FAKTÖRLERİ. In: A. Emre Öge BB, Başar Bilgiç (eds). İTF Nöroloji, e-kitap2019.
  • 7. Owolabi, MO., Thrift, AG., ve ark. (2022). Primary stroke prevention worldwide: translating evidence into action. The Lancet Public Health, 7(1), e74-e85.
  • 8. https://covid19.who.int/ access:21.03.2023
  • 9. Shakil, SS., Emmons-Bell, ve ark. (2022). Stroke among patients hospitalized with COVID-19: results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Stroke, 53(3), 800-807.
  • 10. Pellegrini, L., Albecka, A., ve ark. (2020). SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids. Cell stem cell, 27(6), 951-961.
  • 11. Akhtar, N., Abid, FB., ve ark. (2021). Characteristics and comparison of 32 COVID-19 and non-COVID-19 ischemic strokes and historical stroke patients. Journal of Stroke and Cerebrovascular Diseases, 30(1), 105435.
  • 12. Cenko, E., Badimon, L., ve ark. (2021). Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on thrombosis and the association for acute CardioVascular care (ACVC), in collaboration with the European heart rhythm association (EHRA). Cardiovascular research, 117(14), 2705-2729.
  • 13. Qureshi AI, Abd-Allah F, ve ark. Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel. Int J Stroke. 2020;15(5):540-54.
  • 14. Li Y, Li M, ve ark. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5(3):279-84.
  • 15. Hakbilir O, Çete Y, ve ark. İnme popülasyonun demografik özellikleri ve Gügeç acil servis başvurularının yeni tedavi yaklaşımları üzerine etkisi. Türkiye Acil Tıp Dergisi 2006;6:132–8.
  • 16. Şengün İ. Ş, Kutluk K, ve ark. Atrial fibrilasyonlu iskemik inme hastalarında inme alt tipleri ve diğer risk faktörleri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 2004;18:133–9.
  • 17. Navarrete-Navarro P, Rivera-Fernandez R, ve ark. Outcome prediction in terms of functional disability and mortality at 1 year among ICU-admitted severe stroke patients: a prospective epidemiological study in the south of the European Union (Evascan Project, Andalusia, Spain). Intensive Care Med 2003;29:1237–44.
  • 18. Qureshi, AI., Baskett, WI., ve ark. (2021). Acute ischemic stroke and COVID-19: an analysis of 27 676 patients. Stroke, 52(3), 905-912.
  • 19. Seners P, Ben Hassen W, ve ark. Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone. JAMA Neurol. 2021;78(3):321-8.
  • 20. Yilmaz M. Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Experiences of a Tertiary Hospital in Turkey. diclemedj. March 2021;48(1):55-64. doi:10.5798/dicletip.887410
  • 21. Shi, C., Wang, L., ve ark. (2021). Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis. BMC infectious diseases, 21, 1-15.
  • 22. Danics, K., Pesti, A., ve ark. (2021). A COVID-19-association-dependent categorization of death causes in 100 autopsy cases. Geroscience, 43, 2265-2287.
  • 23. Bastug A, Bodur H, ve ark. Clinical and laboratory features of COVID-19: Predictors of severe prognosis. Int Immunopharmacol. 2020;88:106950.
  • 24. Bertsimas D, Lukin G, ve ark. COVID-19 mortality risk assessment: An international multi-center study. PLoS One. 2020;15(12):e0243262.
  • 25. Richardson S, Hirsch JS, ve ark. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-9.
  • 26. Cheng Y, Luo R, ve ark. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829-38.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Bulaşıcı Hastalıklar, Nöroloji ve Nöromüsküler Hastalıklar
Bölüm Araştırma Makalesi
Yazarlar

Hasan Demirbaş 0009-0000-5207-0500

Ekim Sağlam Gürmen 0000-0002-8672-6181

Bülent Demir 0000-0001-8305-2882

Mustafa Yorgancıoğlu 0000-0002-1101-7284

Yayımlanma Tarihi 27 Haziran 2025
Gönderilme Tarihi 20 Şubat 2025
Kabul Tarihi 25 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 12 Sayı: 2

Kaynak Göster

APA Demirbaş, H., Sağlam Gürmen, E., Demir, B., Yorgancıoğlu, M. (2025). Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 12(2), 289-295. https://doi.org/10.34087/cbusbed.1643518
AMA Demirbaş H, Sağlam Gürmen E, Demir B, Yorgancıoğlu M. Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi. CBU-SBED. Haziran 2025;12(2):289-295. doi:10.34087/cbusbed.1643518
Chicago Demirbaş, Hasan, Ekim Sağlam Gürmen, Bülent Demir, ve Mustafa Yorgancıoğlu. “Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 12, sy. 2 (Haziran 2025): 289-95. https://doi.org/10.34087/cbusbed.1643518.
EndNote Demirbaş H, Sağlam Gürmen E, Demir B, Yorgancıoğlu M (01 Haziran 2025) Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 12 2 289–295.
IEEE H. Demirbaş, E. Sağlam Gürmen, B. Demir, ve M. Yorgancıoğlu, “Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi”, CBU-SBED, c. 12, sy. 2, ss. 289–295, 2025, doi: 10.34087/cbusbed.1643518.
ISNAD Demirbaş, Hasan vd. “Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 12/2 (Haziran2025), 289-295. https://doi.org/10.34087/cbusbed.1643518.
JAMA Demirbaş H, Sağlam Gürmen E, Demir B, Yorgancıoğlu M. Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi. CBU-SBED. 2025;12:289–295.
MLA Demirbaş, Hasan vd. “Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 12, sy. 2, 2025, ss. 289-95, doi:10.34087/cbusbed.1643518.
Vancouver Demirbaş H, Sağlam Gürmen E, Demir B, Yorgancıoğlu M. Covid-19 Pandemisinin Serebrovasküler Hastalıklara Etkisi. CBU-SBED. 2025;12(2):289-95.