Protective Effect of 3-Benzoyl-7-Hydroxy Coumarin on Lipid Peroxidation and Minerals on Rat Liver Tissues Induced Oxidative Stress with Lead Acetate

Abstract

Lead is a toxic substance and damages human metabolism. Coumarin-derived substances have many effects such as antioxidant, anticancer, and antibacterial ones. In this study, the effects of 3-benzoyl-7-hydroxy coumarin on rat liver tissues under oxidative stress with lead acetate were investigated. In the study, rats were divided into 4 groups. Control group (K), Coumarin group (KUM), Lead acetate group (P) and Coumarin+Lead acetate group (KUMP) groups were formed. Malondialdehyde (MDA), lead (Pb), iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) levels were determined in the liver tissues of the rats. MDA level of P group increased compared to the other groups. A decrease was observed in the KUMP group compared to the P group MDA level. While the Pb and Fe levels of the P group increased compared to the K group, the Pb and Fe levels of the KUMP group decreased compared to the P group. As a result, it is concluded that the 3-benzoyl-7-hydroxy coumarin molecule protects the high lipid peroxidation, lead, and iron metabolism caused by lead acetate in the liver.

Keywords

• Toxic
• sprague- dawley
• antioxidant
• malondialdehyde

Kurşun Asetat İle Oksidatif Stres Oluşturulan Rat Karaciğer Dokuları Üzerine 3-Benzoil-7-Hidroksi Kumarin’in Lipit Peroksidasyon ve Mineraller Üzerine Koruyucu Etkisi

Abstract

Kurşun toksik bir maddedir ve insan metabolizmasına hasar vermektedir. Kumarin türevli maddelerin antioksidant, antikanser ve antibakteriyel gibi birçok etkileri vardır. Bu çalışmada, kurşun asetat ile oksidatif stres oluşturulan rat karaciğer dokuları üzerine 3-benzoil-7-hidroksi kumarin’in etkileri araştırıldı. Çalışmada ratlar 4 gruba ayrıldı. Kontrol grubu (K), Kumarin grubu (KUM), Kurşun asetat grubu (P) ve Kumarin+Kurşun asetat grubu (KUMP) grupları oluşturuldu. Ratların karaciğer dokularında malondialdehit (MDA), kurşun (Pb), demir (Fe), çinko (Zn), mangan (Mn) ve bakır (Cu) düzeyleri tespit edildi. P grubu MDA düzeyi diğer gruplara göre arttı. P grubu MDA düzeyine göre KUMP grubunda azalma gözlendi. P grubu Pb ve Fe düzeyi K grubuna göre artarken, KUMP grubu Pb ve Fe düzeyi P grubuna göre azaldı. K grubu Mn düzeyi diğer gruplara göre azaldığı gözlendi. Sonuç olarak kurşun asetatın karaciğerde oluşturduğu yüksek lipit peroksidasyonu, kurşun ve demir metabolizmasını 3-benzoil-7-hidroksi kumarin molekülünün koruduğunu düşünmekteyiz.

Keywords

• Toksik
• sprague- dawley
• antioksidant
• malondialdehit

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