Laboratuvar Hayvan Biliminde 4R Kuralı

Abstract

İnsan organizmasının kompleksliğini tamamen taklit edebilen in vitro modeller hala günümüzde mevcut değildir. Bu modelleme için sıklıkla canlı organ kompleksi olarak laboratuvar hayvanları model olarak kullanılmaktadır. Laboratuvar hayvanları, temel tıp bilimlerinde, ilaçların ve kimyasalların güvenilirlik testlerinde ve eğitim amacıyla kullanılmaktadır. Laboratuvar hayvan biliminde göz önüne alınan temel ilkeler, yerine koyma, azaltma ve iyileştirme olarak tanımlanmıştır. Günümüzde bu ilkelere “sorumluluk” da ilave edilmiştir. Böylelikle 4R kavramı oluşmuştur. Bu yazımızda da bu dört kavram hakkında bilgi verilmesi amaçlanmıştır.

Keywords

• Laboratuvar hayvanı ilkeleri,yerine koyma,azaltma,iyileştirme,sorumluluk

4R Rule in Laboratory Animal Science

Abstract

In vitro models that can completely mimic the complexity of the human organism are still not available today. For this model, laboratory animals are often used as a living organ complex. Laboratory animals are used in basic medical sciences, to test the safety of medicines and chemicals, and for training purposes. The basic principles considered in laboratory animal science are defined as replacement, reduction, and refinement. Nowadays, “responsibility” is added as the fourth principle. Thus, 4R concept was formed. In this article, it is aimed to give detailed information about these four concepts..

Keywords

• Laboratory animal principle,Replacement,Reduction,Refinement,Responsibility

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