Effect of FOXP3 gene variants on the immune-active HBV and inactive HBV phases

Ersin Akgöllü

doi:10.17826/cumj.978353

TR EN

FOXP3 gen varyantlarının immün-aktif HBV ve inaktif HBV fazları üzerindeki etkisi

Öz

Amaç: FOXP3 geni rs2232365 A/G ve rs3761548 A/C polimorfizmleri, Hepatit B virüsü (HBV) enfeksiyonu gibi bağışıklık sistemi ile ilgili hastalıklarla ilişkilendirilmiştir. HBV ile ilişkili karaciğer iltihabının kontrolünde immün baskılayıcı olarak görev yapan Treg hücrelerinin işlevi bu polimorfizmlerden etkilenebilir. Bu çalışmanın amacı, bu polimorfizmlerin HBV enfeksiyon evreleri ile ilişkisini değerlendirmektir. Gereç ve Yöntem: Bu çalışmada, gerçek zamanlı polimeraz zincir reaksiyonu ile immün aktif hepatit B fazında olan 116 hasta ile inaktif hepatit B fazında olan 116 hastada FOXP3 gen polimorfizmleri incelenmiştir. Bulgular: Kadınlarda, rs2232365 polimorfizminin A alleli ve AA genotipi, immün aktif HBV riskini 1.28 ve 1.67 kat artırmasına rağmen istatistiksel olarak anlamlı değildi. Erkeklerde ise rs2232365 polimorfizminin G alelinin immün aktif HBV riskini 1.69 kat arttırdığı ancak istatistiksel olarak anlamlı olmadığı bulunmuştur. Aynı şekilde rs3761548 polimorfizmi de erkek ve kadınlarda istatistiksel olarak anlamlı bir değere ulaşamamıştır. Sonuç: Bu araştırma, Türk popülasyonunda HBV enfeksiyon evreleri ile FOXP3 gen polimorfizmleri arasındaki ilişkiyi gösteren bir çalışmadır. Mevcut çalışmanın sonuçları, bu polimorfizmlerin immün-aktif HBV riskini artırmasına rağmen immün-aktif HBV fazı üzerinde etkisinin olmadığını göstermiştir.

Anahtar Kelimeler

FOXP3 , rs2232365 , rs3761548 , immün-aktif HBV , inaktif HBV

Effect of FOXP3 gene variants on the immune-active HBV and inactive HBV phases

Abstract

Purpose: FOXP3 gene rs2232365 A/G and the rs3761548 A/C polymorphisms were associated with immune system-related diseases such as Hepatitis B virus (HBV) infection. The function of Treg cells which act as immune-suppressors in the control of HBV-related liver inflammation may be affected by these polymorphisms. The aim of the present study was to evaluate the association between these polymorphisms with HBV infection phases. Materials and Methods: The current study examined the FOXP3 gene polymorphisms in 116 patients with immune-active hepatitis B phase and in 116 individuals with inactive hepatitis B phase by a real-time polymerase chain reaction (RT-PCR). Results: In females, the A allele and AA genotype of rs2232365 polymorphism was not statistically significant although it increased 1.28- and 1.67-fold immune-active HBV risk. Although the G allele of rs2232365 polymorphism increased 1.69-fold immune active HBV risk, it was not statistically significant in males, either. Likewise, the rs3761548 polymorphism could not reach a statistically significant value in males and females, either. Conclusion: This research is to demonstrate the relation between phases of HBV infection and polymorphisms of the FOXP3 gene in the Turkish population. The results of this study showed that there is no effect of these polymorphisms on the immune-active phase of HBV, even though it increased immune-active HBV.

Keywords

FOXP3 , rs2232365 , rs3761548 , immune-active HBV , inactive HBV

References

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Ersin Akgöllü ^*
0000-0003-3636-401X
Türkiye

Publication Date

December 30, 2021

Submission Date

August 4, 2021

Acceptance Date

September 25, 2021

Published in Issue

Year 2021 Volume: 46 Number: 4

DOI

https://doi.org/10.17826/cumj.978353

IZ

https://izlik.org/JA99HG94BN

MLA

Akgöllü, Ersin. “Effect of FOXP3 Gene Variants on the Immune-Active HBV and Inactive HBV Phases”. Cukurova Medical Journal, vol. 46, no. 4, Dec. 2021, pp. 1485-92, doi:10.17826/cumj.978353.

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

FOXP3 gen varyantlarının immün-aktif HBV ve inaktif HBV fazları üzerindeki etkisi

Öz

Anahtar Kelimeler

Effect of FOXP3 gene variants on the immune-active HBV and inactive HBV phases

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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