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Evaluation of relationship between body-mass index and spermiogram parameters in subfertile males

Year 2016, Volume: 41 Issue: 2, 299 - 303, 30.06.2016

Abstract

Purpose: The aim of this study was to evaluate the relationship between body-mass index and spermiogram parameters in subfertile maleparameters in male partner of the infertile couples.
Material and Methods: The study was conducted in Infertility Research and Treatment Center of a University Hospital. Hospital records of male partner of 102 infertile couple was considered and patients who had factors possibly had a negative effect on the results of the sperm analysis as chemical agent exposure and systemic disease were excluded, and a total of 94 patients included in the study after this evaluation. These 94 patients were divided in two groups (body-mass index ≤25 and body-mass index >25) and results of the sperm analysis were compared between two groups as primary out-come of the study. These 94 patients were divided in two groups (body-mass index ≤30 and body-mass index >30) and results of the sperm analysis were compared as secondary out-come of the study. 
Results: The mean age (±standart deviation) of the 94 cases included in the study was 34.44±5.58. Distribution of the basal demographic characteristics of the cases according to the body-mass index were similar. Results of the statistical analysis based on the cut-off values of overweight (>25) and obese (>30) were similar in terms of volum, likefaction, total sperm count and total motile sperm count. 
Conclusion: There was no relationship between body-mass index and sperm parameters calculating by conventional sperm analysis.

References

  • Taylor A. ABC of subfertility: extent of the problem. Br Med J. 2003;327:434-36.
  • Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14:482-7.
  • Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433-44.
  • Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222-5.
  • MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16:293-311.
  • Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19:221-31.
  • Thomsen L, Humaidan P, Bungum L, Bungum M. The impact of male overweight on semen quality and outcome of assisted reproduction. Asian J Androl. 2014;16:749-54.
  • Fernandez CD, Bellentani FF, Fernandes GS, Perobelli JE, Favareto AP, Nascimento AF et al. Diet-induced obesity in rats leads to a decrease in sperm motility. Reprod Biol Endocrinol. 2011;9:32.
  • Duale N, Steffensen IL, Andersen J, Brevik A, Brunborg G, Lindeman B. Impaired sperm chromatin integrity in obese mice. Andrology. 2014;2:234-43.
  • Palmer NO, Fullston T, Mitchell M, Setchell BP, Lane M. SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reprod Fertil Dev. 2011;23:929-39.
  • McPherson NO, Lane M. Male obesity and subfertility, is it really about increased adiposity? Asian J Androl. 2015;17:450-8.
  • Paasch U, Grunewald S, Kratzsch J, Glander HJ. Obesity and age affect male fertility potential. Fertil Steril. 2010;94:2898-901.
  • Aggerholm AS, Thulstrup AM, Toft G, Ramlau- Hansen CH, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile. Fertil Steril. 2008;90:619-26.
  • Duits FH, van Wely M, van der Veen F, Gianotten J. Healthy overweight male partners of subfertile couples should not worry about their semen quality. Fertil Steril. 2010;94:1356-9.
  • Sermondade N, Dupont C, Faure C, Boubaya M, Cédrin-Durnerin I, Chavatte-Palmer P, et al. Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males. Asian J Androl. 2013;15:626-9.
  • Liu DY, Baker HW. High frequency of defective sperm–zona pellucida interaction in oligozoospermic infertile men. Hum Reprod. 2004;19:228-33.
  • Oehninger S, Mahony M, Ozgur K, Kolm P, Kruger T, Franken D. Clinical significance of human sperm– zona pellucida binding. Fertil Steril. 1997;67:1121-7.
  • Sekhavat L, Moein MR. The effect of male body mass index on sperm parameters. Aging Male. 2010;13:155-8.

Subfertil erkeklerde vücut-kitle indeksi değeri ile sperm parametreleri ilişkisinin değerlendirilmesi

Year 2016, Volume: 41 Issue: 2, 299 - 303, 30.06.2016

Abstract

Amaç: Bu çalışmanın amacı infertilite yakınması ile hastaneye başvuran erkek eşlerde vücut-kitle indeksi değerleri ile sperm parametreleri arasında ilişki olup olmadığının değerlendirilmesidir.
Gereç ve Yöntem: İnfertilite yakınması ile bir Üniversite Hastanesi İnfertilite Araştırma ve Uygulama Merkezine başvuran toplam 102 erkeğe ait hasta dosyası incelenmiş, kimyasal maruziyeti, sistemik hastalık mevcudiyeti gibi çalışma sonucunu etkileyebilecek özellikte olan olgular dışlandıktan sonra, toplam 94 olgu çalışmaya dahil edilmiştir. Söz konusu olguların dosyalarındaki boy, kilo ölçümüne göre vücut-kitle indeksleri hesaplanmış, spermiyogram analiz sonuçları kaydedilmiştir. Çalışmanın birincil amacı olarak, olgular vücut-kitle indeksi değeri ≤25 (normal) ve >25 (aşırı kilolu) olmak üzere iki gruba ayrılarak gruplar arası sperm parametreleri karşılaştırıldı. İkincil amaç olarak ise, olgular vücut-kitle indeksi değeri ≤30 ve >30 (obez) olmak üzere iki gruba ayrılarak gruplar arası sperm parametreleri karşılaştırıldı. 
Bulgular: Çalışmaya dahil edilen toplam 94 olgunun yaş ortalaması 34.44±5.58 (ortalama±standart sapma) şeklinde idi. Olguların bazal demografik verilerinin vücut-kitle indeksine göre dağılımı homojendir. Vücut-kitle indeksi değerine göre aşırı kiloluluk (>25) ve obezite (>30) sınır olarak kabul edilerek yapılan her iki analiz sonucunda gruplar arasında volüm, likefaksiyon, total sperm sayısı ve total motil sperm sayısı yönlerinden anlamlı fark olmadığı bulunmuştur. 
Sonuç: Vücut-kitle indeksi değeri ile konvansiyonel spermiyogram ile değerlendirilen sperm parametreleri arasında bağlantı bulunmamaktadır.

References

  • Taylor A. ABC of subfertility: extent of the problem. Br Med J. 2003;327:434-36.
  • Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14:482-7.
  • Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433-44.
  • Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222-5.
  • MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16:293-311.
  • Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19:221-31.
  • Thomsen L, Humaidan P, Bungum L, Bungum M. The impact of male overweight on semen quality and outcome of assisted reproduction. Asian J Androl. 2014;16:749-54.
  • Fernandez CD, Bellentani FF, Fernandes GS, Perobelli JE, Favareto AP, Nascimento AF et al. Diet-induced obesity in rats leads to a decrease in sperm motility. Reprod Biol Endocrinol. 2011;9:32.
  • Duale N, Steffensen IL, Andersen J, Brevik A, Brunborg G, Lindeman B. Impaired sperm chromatin integrity in obese mice. Andrology. 2014;2:234-43.
  • Palmer NO, Fullston T, Mitchell M, Setchell BP, Lane M. SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. Reprod Fertil Dev. 2011;23:929-39.
  • McPherson NO, Lane M. Male obesity and subfertility, is it really about increased adiposity? Asian J Androl. 2015;17:450-8.
  • Paasch U, Grunewald S, Kratzsch J, Glander HJ. Obesity and age affect male fertility potential. Fertil Steril. 2010;94:2898-901.
  • Aggerholm AS, Thulstrup AM, Toft G, Ramlau- Hansen CH, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile. Fertil Steril. 2008;90:619-26.
  • Duits FH, van Wely M, van der Veen F, Gianotten J. Healthy overweight male partners of subfertile couples should not worry about their semen quality. Fertil Steril. 2010;94:1356-9.
  • Sermondade N, Dupont C, Faure C, Boubaya M, Cédrin-Durnerin I, Chavatte-Palmer P, et al. Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males. Asian J Androl. 2013;15:626-9.
  • Liu DY, Baker HW. High frequency of defective sperm–zona pellucida interaction in oligozoospermic infertile men. Hum Reprod. 2004;19:228-33.
  • Oehninger S, Mahony M, Ozgur K, Kolm P, Kruger T, Franken D. Clinical significance of human sperm– zona pellucida binding. Fertil Steril. 1997;67:1121-7.
  • Sekhavat L, Moein MR. The effect of male body mass index on sperm parameters. Aging Male. 2010;13:155-8.
There are 18 citations in total.

Details

Primary Language English
Journal Section Research
Authors

Pınar Hasdemir

Melek Kamalı This is me

Esat Çalık This is me

Hasan Özçakır This is me

Publication Date June 30, 2016
Published in Issue Year 2016 Volume: 41 Issue: 2

Cite

MLA Hasdemir, Pınar et al. “Evaluation of Relationship Between Body-Mass Index and Spermiogram Parameters in Subfertile Males”. Cukurova Medical Journal, vol. 41, no. 2, 2016, pp. 299-03, doi:10.17826/cutf.210160.