Role of whole blood markers in carbon monoxide poisoning

Year 2019, Volume: 44 Issue: Supplement 1, 197 - 201, 29.12.2019

Birsen Ertekin , Sedat Koçak Tarık Acar Esma Öztürk Lütfi Saltuk Demir

https://doi.org/10.17826/cumj.553701

Cited By: 5

Abstract

Purpose: Carbon monoxide (CO) poisoning is one of the most common causes of fatal suicide or accidental poisoning worldwide. There is no specific biomarker in the diagnosis. Therefore, the role of whole blood parameters in CO poisoning was investigated.

Material and Methods: A total of 442 patients diagnosed with CO intoxication at the emergency department between January 1, 2014 and January 1, 2016 were included in the study retrospectively. The demographic characteristics of the patient group and the complete blood results were obtained from the hospital registry system. The control group consisted of 100 patients presenting with similar complaints to the emergency department. Leukocyte (WBC), red cell distribution width (RDW), platelet, lymphocyte, neutrophil, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) values of both groups were compared statistically.

Results: The patient and control groups were similar in age and gender. The WBC, RDW, Platelet, Lymphocyte, Neutrophil, NLR and PLR levels of the patient group were significantly higher compared to the control group. However, there was no significant correlation between patient admission time and Glaskow Coma Scale (GCS), carboxyhemoglobin (COHb), RDW, NLR and PLR levels.

Conclusion: Our study suggested that RDW, NLR and PLR levels have potential to be a useful marker for the diagnosis of CO poisoning. 

Keywords

Carbon monoxide, neutrophil lymphocyte ratio, platelet lymphocyte ratio, red cell distribution width

Karbonmonoksit zehirlenmesinde tam kan belirteçlerinin rolü

Abstract

Amaç: Karbonmonoksit (CO) zehirlenmesi dünya çapındaki ölümcül intihar veya kazara zehirlenmelerin en yaygın nedenlerinden birisidir. Tanısında spesifik bir biyobelirteç yoktur. Bu sebeple çalışmada CO zehirlenmesinde tam kan parametreleri’nin rolü araştırılmıştır.

Gereç ve Yöntem: Çalışmada 1 Ocak 2014 – 1 Ocak 2016 tarihleri arasında acil serviste CO zehirlenmesi tanısı alan ve dışlama kriterlerini sağlayan toplam 442 hasta retrospektif olarak incelendi. Hasta grubunun demografik özellikleri ve tam kan sonuçlarına hastane kayıt sisteminden ulaşıldı. Kontrol grubu acil servise benzer şikâyetler ile başvuran 100 hastadan oluşturuldu. Her iki grubun lökosit (WBC), kırmızı hücre dağılım genişliği (RDW), platelet, lenfosit, nötrofil, nötrofil-lenfosit oranı (NLR) ve platelet-lenfosit oranı (PLR) değerleri istatistiksel olarak karşılaştırıldı. 

Bulgular: Hasta ve kontrol grubu yaş ve cinsiyet bakımından birbirleri ile benzerdi. Hasta grubunun WBC, RDW, Platelet, Lenfosit, Nötrofil, NLR ve PLR değerleri kontrol grubu ile kıyaslandığında anlamlı derece yüksek bulundu. Ancak hasta yatış süreleri ile Glaskow Koma Skalası (GKS), karboksihemoglobin (COHb), RDW, NLR ve PLR düzeyleri arasında anlamlı bir korelasyon bulunmamıştır.

Sonuç: Çalışmamız RDW, NLR ve PLR düzeylerinin CO zehirlenmesi tanısını öngörmede kullanılabilir bir biyobelirteç olma potansiyeli olduğunu düşündürmüştür. 

Keywords

Karbonmonoksit, nötrofil lenfosit oranı, platelet lenfosit oranı, kırmızı kan hücreleri dağılım genişliği

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