Acute necrotizing encephalopathy of childhood: a Turkish case

Year 2014, Volume: 39 Issue: 3, 641 - 645, 22.07.2014

Olcay Ünver Zehra İşık Hasıloğlu Sezgin Şahin Mehmet Sait Albayram Yücel Taştan

https://doi.org/10.17826/cutf.54839

Abstract

Acute necrotizing encephalopathy of childhood (ANEC) is a rare form of acute encephalopathy of unknown etiology characterized by typical symmetrical lesions in the thalami, with variable involvement of the white matter, brainstem and cerebellum. Clinically there is a rapid neurologic deterioration after a short period of a nonspecific viral-like illness associated with gastrointestinal or respiratory signs. Asian children are especially affected. Here we present a 3-year-old boy admitted to our hospital with fever and deterioration of consciousness. The diagnosis of ANEC was made by radiologic findings

Keywords

acute necrotizing encephalopathy, children, parainfluenza virus

Çocukluk çağının akut nekrotizan ensefalopatisi: Türkiye'den bir olgu

Abstract

Çocukluk çağının akut nekrotizan ensefalopatisi, talamusta tipik, simetrik lezyonlarla, ak madde, beyin sapı ve serebellumun değişken tutulumuyla nitelenen, etiyolojisi bilinmeyen, nadir bir akut ensefalittir. Klinikte, gastrointestinal veya solunum sistemini etkileyen viral enfeksiyonlar sonrasında hızlı nörolojik bozulma izlenir. Asya kökenli çocuklarda daha sık görülür. Bu yazıda, bilinç bulanıklığı, ve ateş nedeniyle hastanemize başvuran, akut nekrotizan ensefalopati tanısı radyolojik bulgular ile konulan 3 yaşında bir erkek olgu sunuldu

Keywords

akut nekrotizan ensefalopati, çocukluk çağı, parainfluenza virus

References

• Mizuguchi M, Abe J, Mikkaichi K, Noma S, Yoshida K, Yamanaka T, Kamoshita S. Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. Journal of Neurology, Neurosurgery, and Psychiatry. 1995;58:555-61.
• San Milan B, Teijeira S, Penin C, Garcia JL, Navarro C. Acute necrotizing encephalopathy of childhood: report of a Spanish case. Pediatr Neurol. 2007;37:438-41.
• Güzel A, Karasalihoğlu S, Ünlü E, Küçükuğurluoğlu Y, Bulut H. Akut nekrotizan ensefalopati. Türkiye Klinikleri J Pediatr. 2012;21:40-4.
• Skelton BW, Hollingshead MC, Sledd AT, Phillips D, Castillo M. Acute necrotizing encephalopathy of childhood: typical findings in an atypical disease. Pediatr Radiol. 2008;38:810-13.
• Albayram S, Bilgi Z, Selcuk H, et al. Diffusionweighted MR imaging findings of acute necrotizing encephalopathy. AJNR. 2004;25:792-7.
• Mastroyianni SD, Voudris KA, Katsarou E et al. Acute necrotizing encephalopathy associated with parainfluenza virus in a caucasian child: J Child Neurol. 2003;18:570-2.
• Ohsaka M, Houkin K, Takigami M, Koyanagi I. Acute necrotizing encephalopathy associated with human herpesvirus-6 infection. Pediatr Neurol. 2006;34:160
• Mastroyianni SD, Gionnis D, Voudris K, Skardoutsou A, Mizuguchi M. Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review. J Child Neurol. 2006;21:872-79.
• Marco EJ, Anderson JE, Neilson DE, Jonathan B, Strober JB. Acute necrotizing encephalopathy in 3 brothers. Pediatrics. 2010;125:693-98.
• Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain & Development. 1997;19:81-92.
• Munakata M, Kato R, Yokoyama H, et al. Combined therapy with hypotermia and anticytokine agents in influenza A encephalopathy. Brain Dev. 2000;22:373
• Martin A, Reade EP. Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clinical Infectious Diseases. 2010;50:50-2.
• Kömür M, Okuyaz Ç, Arslankoylu AE, Kara E, Atici A. Acute necrotizing encephalopathy associated with novel influenza A (H1N1) virus in Turkey. J Pak Med Assoc. 2011;61:1237-9.
• Wong A, Simone E, Zimmerman R et al. Acute necrotizing encephalopathy of childhood: correlation of MR findings and clinical outcome. AJNR Am J Neuroradiol. 2006;27:1919-23.
• Sugaya N. Influenza-associated encephalopathy in Japan. Semin Pediatr Infect Dis. 2002;13:79-84.
• Vilensky JA, Foley P, Gilman S. Children and encephalitis lethargica: a historical review. Pediatr Neurol. 2007;37:79-84.
• Maladrini A, Luchini D, Gambelli S, et al. A syndrome of bilateral hemorrhage of the thalamus and myocarditis with fatal course. J Clin Forensic Med. 2004;11:208-10.
• Voudris KA, Skardoutsou A, Haronitis I, et al: Brain MRI findings in influenza A-associated acute necrotizing encephalopathy of childhood. Eur J Paediatr Neurol. 2001;5:199-202.
• Tran TD, Kubota M, Takeshita K, et al: Varicellaassociated acute necrotizing encephalopathy with a good prognosis. Brain Dev. 2001;23:54-7.
• Olgar S, Ertugrul T, Nisli K, Aydin K, Caliskan M. Influenza A associated acute necrotizing encephalopathy. Neuropediatrics. 2006;37:166-8.
• Morishima T. Treatment of influenza associated encephalopathy [in Japanese]. Nippon Rinsho. 2003;61:2006-12.
• Yazışma Adresi / Address for Correspondence: Dr. Olcay Ünver İstanbul University Cerrahpaşa Medical Scholl Department of Pediatric Neurology Tel: [phone] Fax: [phone]
• Email: [e-mail]. G eliş tarihi/Received on:15.11.2013
• Kabul tarihi/Accepted on:26.12.2013