Non-alkolik yağlı karaciğer hastalığında kafein alımı ve karaciğer biyobelirteçleri arasındaki ilişki

Year 2023, Volume: 48 Issue: 1, 177 - 186, 31.03.2023

Kübra Uçar Evrim Kahramanoğlu Zeynep Göktaş

https://doi.org/10.17826/cumj.1171396

Abstract

Amaç: Non-alkolik yağlı karaciğer hastalığı (NAFLD), gelişmiş ülkelerde karaciğer enzimlerindeki yükselmenin en yaygın nedenidir. Bu çalışmanın amacı, NAFLD olan bireylerde kafein alımının karaciğer metabolizmasının bazı parametreleri üzerindeki etkilerini incelemektir.
Gereç ve Yöntem: Çalışmaya NAFLD tanısı almış 19-64 yaş arasında toplam 20 kadın ve 20 erkek birey dahil edilmiştir. Kafein alımını belirlemek için, deneyimli bir diyetisyen tarafından özel olarak geliştirilmiş kafein-besin alım sıklığı anketi uygulanmıştır. Bireyler kafein alımlarına göre 3 gruba ayrılmıştır; Grup 1: ≤150 mg/gün, Grup 2: 150-250 mg/gün ve Grup 3: ≥250 mg/gün. Antropometrik ölçümler ve biyokimyasal parametreler kaydedilmiştir. Serum örneklerindeki protein miktarları ELISA yöntemi ile belirlenmiştir.
Bulgular: Grup 1'in vücut yağ kompozisyonu grup 2'den daha yüksektir. Grup 3'ün alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST) düzeyleri sırasıyla grup 1'den ve grup 2'den daha yüksektir. Grup 3'ün yüksek yoğunluklu lipoprotein kolesterol (HDL-C) düzeyi grup 1 ve grup 2'den daha düşüktür. Toplam kafein alımı ile ALT düzeyi arasında pozitif bir ilişki vardır. Kafein alım grupları arasında serum protein düzeyleri açısından anlamlı bir farklılık yoktur. Ayrıca serum protein seviyeleri ile toplam kafein alımı arasında anlamlı bir korelasyon bulunmamıştır.
Sonuç: ≥250 mg/gün kafein alımı, NAYKH olan bireylerde ALT ve AST düzeylerini yükseltebilir ve HDL-C düzeyini düşürebilir.

Keywords

Non-alkolik yağlı karaciğer hastalığı, kafein, alanin aminotransferaz, aspartat aminotransferaz, yüksek yoğunluklu lipoprotein

Association between caffeine intake and liver biomarkers in non-alcoholic fatty liver disease

Abstract

Purpose: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver enzymes in developed countries. The aim of this study is to examine the effects of caffeine intake on some parameters of liver metabolism in individuals with NAFLD.
Materials and Methods: A total of 20 female and 20 male subjects between the ages of 19 to 64, who were diagnosed with NAFLD, were included in the study. To determine caffeine intake, a specially developed caffeine-food frequency questionnaire was administered by a trained dietitian. Individuals were categorized into 3 groups according to their caffeine intake; Group 1: ≤150 mg/day, Group 2: 150-250 mg/day, and Group 3: ≥250 mg/day. Anthropometric measurements and biochemical parameters were recorded. Protein quantities in serum samples were determined by ELISA method.
Results: The body fat composition of group 1 was higher than group 2. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of group 3 were higher than group 1 and group 2, respectively. High-density lipoprotein cholesterol (HDL-C) level of group 3 was lower than group 1 and group 2. There was a positive correlation between total caffeine intake and ALT level. There was no significant difference between the caffeine intake groups in terms of serum protein levels. In addition, there was not found significant correlation between serum protein levels and total caffeine intake.
Conclusion: Caffeine intake of ≥250 mg/day may increase ALT and AST levels and decrease HDL-C level in individuals with NAFLD.

Keywords

Non-alcoholic fatty liver disease, caffeine, alanine aminotransferase, aspartate aminotransferase, high-density lipoprotein

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