Plasma kallistatin levels in patients with COVID-19

Year 2023, Volume: 48 Issue: 4, 1199 - 1206, 29.12.2023

Kamile Yucel , Salih Yıldız , Ali Fuat Gurbuz

https://doi.org/10.17826/cumj.1316587

Abstract

Purpose: The aim of this study was to evaluate kallistatin levels in patients diagnosed with COVID-19 and compare them with healthy controls.
Materials and Methods: A total of 40 patients diagnosed with COVID-19, and 45 healthy controls were included in the study. The patient group was divided into 2 groups: patients treated in the service (n:20) and patients treated in the intensive care unit (n:20). Kallistatin levels were measured using the ELISA method.
Results: There was a significant difference in kallistatin levels between the patient group (n:40) and the control group (n:45). There was no significant difference in kallistatin between COVID-19 patients treated in the service and those treated in the intensive care unit. We found that the AUC for kallistatin was 0.856 in the ROC analysis performed between the patient and control groups. When comparing service and ICU patients in terms of laboratory parameters, there was a significant difference between the groups due to elevated potassium, AST, creatinine, ferritin, HGB and LDH in ICU patients.
Conclusion: As a result, kallistatin levels were significantly higher in the patient group than in the control group. Comprehensive studies with more patients are needed to understand whether kallistatin is elevated in COVID-19 patients due to the effects of COVID-19 or to eliminate oxidative stress.

Keywords

COVID-19, enzim bağlı immünosorbent testi, kallistatin

Supporting Institution

This research is financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK)

Project Number

Grant/Award Number: BIDEP-2209A Number: 1919B012109027.

COVID-19 hastalarında plazma kallistatin düzeyleri

Abstract

Amaç: Bu çalışmanın amacı, COVID-19 tanısı alan hastalarda kallistatin düzeylerini değerlendirmek ve sağlıklı kontrollerle karşılaştırmaktı.
Gereç ve Yöntem: Çalışmaya COVID-19 tanısı alan 40 hasta ve 45 sağlıklı kontrol dahil edildi. Hasta grubu serviste tedavi görenler (n:20) ve yoğun bakımda tedavi görenler (n:20) olmak üzere 2 gruba ayrıldı. Kallistatin seviyeleri ELISA yöntemi kullanılarak ölçüldü.
Bulgular: Hasta grubu (n:40) ile kontrol grubu (n:45) arasında kallistatin düzeyleri açısından anlamlı fark vardı. Serviste tedavi edilen COVID-19 hastaları ile yoğun bakımda tedavi edilenler arasında kallistatin açısından anlamlı fark yoktu. Hasta ve kontrol grubu arasında yapılan ROC analizinde kallistatinin EAA'sını 0.856 olarak bulduk. Servis ve yoğun bakım hastaları laboratuvar parametreleri açısından karşılaştırıldığında, yoğun bakım hastalarında potasyum, AST, kreatinin, ferritin, HGB ve LDH yükselişi nedeniyle gruplar arasında anlamlı fark vardı.
Sonuç: Sonuç olarak hasta grubunda kallistatin düzeyleri kontrol grubuna göre anlamlı olarak yüksekti. COVID-19 hastalarında kallistatinin COVID-19'un etkileri nedeniyle mi yoksa oksidatif stresi ortadan kaldırmak için mi yükseldiğini anlamak için daha fazla hasta ile yapılacak daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

COVID-19, enzim bağlı immünosorbent testi, kallistatin

Project Number

Grant/Award Number: BIDEP-2209A Number: 1919B012109027.

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