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İnsülin direnci seboreik dermatitte yeni bir komorbidite mi: bir vaka kontrol çalışması

Year 2023, Volume: 48 Issue: 4, 1293 - 1298, 29.12.2023
https://doi.org/10.17826/cumj.1354195

Abstract

Amaç: Seboreik dermatit (SD), etiyolojisi bilinmeyen kronik inflamatuar bir deri hastalığıdır. Mevcut çaışmalardan elde edilen veriler obezitesi olan bireylerde SD prevalansının daha yüksek olduğunu göstermektedir. İnsülin direnci (IR), kandaki glisemiyi dengelemek için gereken yüksek insülin seviyeleri ile karakterize edilen metabolik bir durumdur ve obezite bunun klinik belirtilerinden biridir. Bu çalışma literatürde insülin direnci IR ile SD arasındaki ilişkiyi ortaya koyan ilk prospektif araştırmalardan birini sunmaktadır.
Gereç ve Yöntem: Bu vaka-kontrol çalışmasına toplam 71 katılımcı dahil edildi: 35 SD hastası (15 erkek/20 kadın) ve 36 kontrol (15 erkek/21 kadın). Tüm katılımcılar aynı dermatoloji uzmanı tarafından seboreik dermatit varlığı veya yokluğu açısından klinik olarak değerlendirildi. Her iki grupta da HOMA-IR, insülin seviyeleri, serum lipit seviyeleri, bel çevresi ve vücut kitle indeksi (BMI) gibi parametreler ölçüldü.
Bulgular: SD'li hastalarda HOMA-IR, insülin, toplam kolesterol, LDL kolesterol, bel çevresi ve BMI düzeyleri kontrol grubuyla karşılaştırıldığında daha yüksekti. HOMA-IR ile bel çevresi, BMI, diyastolik kan basıncı ve trigliserit düzeyleri arasında anlamlı pozitif korelasyonlar bulundu.
Sonuç: Bu çalışma insülin direncinin IR'nin seboreik dermatitte yeni bir komorbid faktör olabileceğini düşündürmektedir. SD ile insülin direnci arasında muhtemelen ortak inflamatuar patogenezden dolayı önemli bir ilişki gözlendi. Sonuç olarak, sağlıklı bir yaşam tarzı sürdürmenin önemi vurgulanarak SD'li bireyler insülin direnciyle ilişkili durumlar açısından izlenmelidir.

References

  • Saklayen MG. The global epidemic of the metabolic syndrome.Curr Hypertens Rep. 2018;20:12.
  • Uzuncakmak TK, Akdeniz N, Karadag AS. Cutaneous manifestations of obesity and themetabolic syndrome. Clin Dermatol. 2018;36:81-8.
  • Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013;31:343-51.
  • Sodagar S, Ghane Y, Heidari A, Heidari N, Ahmadi SAY, Seirafianpour F et al. Association between metabolic syndrome and prevalentskin diseases: A systematic review and meta-analysis of case-control studies Health Sci Rep. 2023;6:e1576.
  • Karadağ AS, You Y, Danarti R, Al-Khuzaei S, Chen W. Acanthosis nigricans and the metabolic syndrome. Clin Dermatol. 2018;36:48-53.
  • Gelfand JM, Yeung H. Metabolic syndrome in patients with psoriatic disease. J Rheumatol Suppl. 2012;89:24-8.
  • Imamoglu B, Hayta SB, Guner R, Akyol M, Ozcelik S. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atheroscler Dis. 2016;1:158-61.
  • World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310:2191-4.
  • Bartnik AB, Kocalek P, Owczarek AJ, Choręza PS, Markuszewski L, Paweł Madej P et al. The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome. Front Med (Lausanne) 2023:10:1100547.
  • Ozgul A, Altunisik N, Turkmen D, Sener S. The relationship between seborrheic dermatitis and body composition parameters. North Clin Istanb. 2023;10:271-6.
  • Dowlati B, Firooz A, Khamesipour A, Lotfi M, Stuart CA, Smith EB et al. Insulin quantification in patients with seborrheic dermatitis. Arch Dermatol. 1998;134:1043-5.
  • Savaş Erdogan S, Falay Gür T, Özkur E, Doğan D. Insulin resistance and metabolic syndrome in patients with seborrheic dermatitis: a case-control study. Metab Syndr Relat Disord. 2022;20:50-.
  • Akbaş A, Kılınç F, Şener S, Hayran Y. Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters. J Cosmet Dermatol. 2022;21:6079-85.
  • Sobhan M , Nazari F, Mohammadi Y. Correlation between seborrheic dermatitis and metabolic syndrome in patients referred to Sina Hospital of Hamadan. Avicenna J Clin Med. 2020;27:13-20.
  • Faergemann J, Bergbrant IM, Dohsé M, Scott A, Westgate G. Seborrhoeic dermatitis and Pityrosporum (Malassezia) folliculitis: characterization of inflammatory cells and mediators in the skin by immunohistochemistry. Br J Dermatol. 2001;144:549-56.
  • Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A. The Malassezia genus in skin and systemic diseases. Clin Microbiol Rev. 2012;25:106-41.
  • Yamanaka K, Mizutani H. "Inflammatory skin march": IL-1-mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events. J Allergy Clin Immunol. 2015;136:823-4.
  • Chang CC, Wu CL, Su WW, Shih KL, Tarng DC, Chou CT et al. Interferon gamma-induced protein is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease. Sci Rep. 2015;5:10096.
  • Tosun M, Yasak Güner R, Akyol M,Investigation of the relationship between inflammatory blood parameters and seborrheic dermatitis. J Cosmet Dermatol. 2022;21:5111-5.

Is insulin resistance a new comorbidity in seborrheic dermatitis: a case control study

Year 2023, Volume: 48 Issue: 4, 1293 - 1298, 29.12.2023
https://doi.org/10.17826/cumj.1354195

Abstract

Purpose: Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder with an unknown etiology. Data from studies show that the prevalence of SD is higher in individuals with obesity. Insulin resistance (IR) is a metabolic condition characterized by high levels of insulin required to balance blood glycemia, and obesity is one of its clinical manifestations. This study presents one of the first prospective studies revealing the relationship between IR and SD in the literature.
Materials and Methods: In this case-control study, a total of 71 participants were included: 35 SD patients (15 males/20 females) and 36 controls (15 males/21 females). All participants were clinically evaluated for the presence or absence of seborrheic dermatitis by the same dermatologist. Parameters including HOMA-IR, insulin levels, serum lipid levels, waist circumference, and BMI were measured in both groups.
Results: HOMA-IR, insulin, total cholesterol, LDL cholesterol, waist circumference and BMI levels were higher in SD patients compared to the control group. Significant positive correlations were found between HOMA-IR and waist circumference, BMI, diastolic blood pressure, and triglyceride levels.
Conclusion: This study suggests that IR could be a new comorbid factor in seborrheic dermatitis. A substantial association was observed between SD and insulin resistance, possibly due to shared inflammatory pathogenesis. Consequently, individuals with SD should be monitored for insulin resistance-related conditions, emphasizing the importance of maintaining a healthy lifestyle.

References

  • Saklayen MG. The global epidemic of the metabolic syndrome.Curr Hypertens Rep. 2018;20:12.
  • Uzuncakmak TK, Akdeniz N, Karadag AS. Cutaneous manifestations of obesity and themetabolic syndrome. Clin Dermatol. 2018;36:81-8.
  • Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013;31:343-51.
  • Sodagar S, Ghane Y, Heidari A, Heidari N, Ahmadi SAY, Seirafianpour F et al. Association between metabolic syndrome and prevalentskin diseases: A systematic review and meta-analysis of case-control studies Health Sci Rep. 2023;6:e1576.
  • Karadağ AS, You Y, Danarti R, Al-Khuzaei S, Chen W. Acanthosis nigricans and the metabolic syndrome. Clin Dermatol. 2018;36:48-53.
  • Gelfand JM, Yeung H. Metabolic syndrome in patients with psoriatic disease. J Rheumatol Suppl. 2012;89:24-8.
  • Imamoglu B, Hayta SB, Guner R, Akyol M, Ozcelik S. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atheroscler Dis. 2016;1:158-61.
  • World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310:2191-4.
  • Bartnik AB, Kocalek P, Owczarek AJ, Choręza PS, Markuszewski L, Paweł Madej P et al. The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome. Front Med (Lausanne) 2023:10:1100547.
  • Ozgul A, Altunisik N, Turkmen D, Sener S. The relationship between seborrheic dermatitis and body composition parameters. North Clin Istanb. 2023;10:271-6.
  • Dowlati B, Firooz A, Khamesipour A, Lotfi M, Stuart CA, Smith EB et al. Insulin quantification in patients with seborrheic dermatitis. Arch Dermatol. 1998;134:1043-5.
  • Savaş Erdogan S, Falay Gür T, Özkur E, Doğan D. Insulin resistance and metabolic syndrome in patients with seborrheic dermatitis: a case-control study. Metab Syndr Relat Disord. 2022;20:50-.
  • Akbaş A, Kılınç F, Şener S, Hayran Y. Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters. J Cosmet Dermatol. 2022;21:6079-85.
  • Sobhan M , Nazari F, Mohammadi Y. Correlation between seborrheic dermatitis and metabolic syndrome in patients referred to Sina Hospital of Hamadan. Avicenna J Clin Med. 2020;27:13-20.
  • Faergemann J, Bergbrant IM, Dohsé M, Scott A, Westgate G. Seborrhoeic dermatitis and Pityrosporum (Malassezia) folliculitis: characterization of inflammatory cells and mediators in the skin by immunohistochemistry. Br J Dermatol. 2001;144:549-56.
  • Gaitanis G, Magiatis P, Hantschke M, Bassukas ID, Velegraki A. The Malassezia genus in skin and systemic diseases. Clin Microbiol Rev. 2012;25:106-41.
  • Yamanaka K, Mizutani H. "Inflammatory skin march": IL-1-mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events. J Allergy Clin Immunol. 2015;136:823-4.
  • Chang CC, Wu CL, Su WW, Shih KL, Tarng DC, Chou CT et al. Interferon gamma-induced protein is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease. Sci Rep. 2015;5:10096.
  • Tosun M, Yasak Güner R, Akyol M,Investigation of the relationship between inflammatory blood parameters and seborrheic dermatitis. J Cosmet Dermatol. 2022;21:5111-5.
There are 19 citations in total.

Details

Primary Language English
Subjects Dermatology, Endocrinology
Journal Section Research
Authors

Burak Akşan 0000-0002-3052-5014

Oguz Dikbas 0000-0001-9875-6065

Publication Date December 29, 2023
Acceptance Date December 3, 2023
Published in Issue Year 2023 Volume: 48 Issue: 4

Cite

MLA Akşan, Burak and Oguz Dikbas. “Is Insulin Resistance a New Comorbidity in Seborrheic Dermatitis: A Case Control Study”. Cukurova Medical Journal, vol. 48, no. 4, 2023, pp. 1293-8, doi:10.17826/cumj.1354195.