Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

Year 2023, Volume: 48 Issue: 4, 1347 - 1356, 29.12.2023

Cüneyt Tayman , Ufuk Çakır

https://doi.org/10.17826/cumj.1366249

Abstract

Amaç: Neonatoloji alanında sistemik inflamatuar indekslere ilişkin bilgiler sınırlıdır. Cinsiyet ve doğum şeklinin sistemik inflamatuar indeksleri nasıl etkilediği bilinmemektedir. Çalışmamızın amacı preterm bebeklerde doğum şeklinin ve cinsiyetin sistemik inflamatuar indekslere etkisini değerlendirmektir.
Gereç ve Yöntem: 32 haftanın altındaki prematüre bebekler retrospektif olarak değerlendirildi. Tam kan sayımı parametreleri, monosit-lenfosit oranı (MLR), nötrofil-lenfosit oranı (NLR), pan immün inflamasyon değeri (PIV), trombosit-lenfosit oranı (PLR), sistemik immün inflamasyon indeksi (SII), sistemik inflamasyon yanıt indeksi (SIRI), demografik ve klinik özellikler cinsiyet ve doğum şekli açısından karşılaştırıldı.
Bulgular: Çalışmamızda 1322 prematüre bebek değerlendirildi. Lökosit, trombosit, nötrofil, monosit, lenfosit sayısı, hemoglobin düzeyleri, NLR, MLR, PLR, PIV, SII ve SIRI değerleri cinsiyetler arasında benzer bulundu. Lökosit, nötrofil, monosit, lenfosit sayısı, hemoglobin düzeyleri, MLR, PLR ve SIRI değerleri doğum şekline göre anlamlı farklılık göstermedi. Sezaryen grubunda trombosit sayısı (225 103 µ/L), NLR (0,30), PIV (42,17) ve SII (67,86) değerleri vajinal doğum grubuna (trombosit sayısı: 248 103 µ/L, NLR: 0,44, PIV: 80,88 ve SII: 91.63) göre daha düşüktü.
Sonuç: Çalışmamızda cinsiyetin sistemik inflamatuar indeksler üzerine etkisinin olmadığı ve <32 haftadan önce doğan prematüre bebeklerde sezaryen doğumda NLR, PIV ve SII'nin daha düşük olduğu gösterilmiştir.

Keywords

Yenidoğan, Nötrofil-lenfosit oranı, Pan immün inflamasyon değeri, Prematüre, Sistemik immün inflamasyon indeksi

Ethical Statement

Bu çalışma için Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Klinik Araştırmalar Etik Kurulu'ndan 11.04.2019 tarih ve 48/2019 sayılı kararla etik onay alındı.

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

Effect of sex and mode of delivery on systemic inflammatory indices in preterm infants

Abstract

Purpose: Information on systemic inflammatory indices in the field of neonatology is limited. How sex and mode of delivery affects systemic inflammatory indices is unknown. The aim of our study was to evaluate the effect of mode of delivery and sex on systemic inflammatory indices in preterm infants.
Materials and Methods: Preterm infants <32 weeks of gestation were evaluated retrospectively. Complete blood count parameters, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), pan immune inflammation value (PIV), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI), demographic and clinical characteristics were compared in terms of sex and mode of delivery.
Results: In our study, 1322 preterm infants were evaluated. Leukocyte, platelet, neutrophil, monocyte, lymphocyte count, hemoglobin levels, NLR, MLR, PLR, PIV, SII, and SIRI values were found to be similar between genders. Leukocyte, neutrophil, monocyte, lymphocyte count, hemoglobin levels, MLR, PLR, and SIRI values did not differ significantly according to mode of delivery. The values of platelet count (225 103 µ/L), NLR (0.30), PIV (42.17) and SII (67.86) in the cesarean section group were higher than those in the vaginal delivery group (platelet count: 248 103 µ/L, NLR: 0.44, PIV: 80.88 and SII: 91.63).
Conclusion: Gender had no effect on systemic inflammatory indices and NLR, PIV, and SII were lower in cesarean delivery in preterm infants born <32 weeks of gestation.

Keywords

Infant, Neutrophil-to-lymphocyte ratio, Pan immune inflammation value, Premature, Systemic immune-inflammation index

Ethical Statement

For this study, ethical approval was obtained from the Clinical Research Ethics Committee of Zekai Tahir Burak Women’s Health Training and Research Hospital with a decision dated 11.04.2019 and numbered 48/2019.

Supporting Institution

None

Project Number

Yok

Thanks

None

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