Abstract
In this study, magnetic alginate beads were successfully synthesized by integrating superparamagnetic iron oxide nanoparticles (Fe3O4) in sodium alginate microbeads during the synthesis. The as-obtained dried samples were analyzed by means of their water detention capacity and drug encapsulation efficiency. Further, an anti-inflammatory drug (Cefazolin), mostly used for the treatment of joint inflammations after surgery, was used as a model drug in order to evaluate the stimuli-responsive properties of macrocomposites under magnetic field for the development of on-site drug delivery system. To do so, their drug release kinetics at changing environmental conditions, such as pH, temperature, and magnetic field were investigated and compared with bare alginate beads
References
- Bhatia D, Bejarano T, Novo M. Current Interventions in the Management of Knee Osteoarthritis, J. Pharm. Bioallied Sci., Vol. 5, No. 1, 2013, pp.30–38.
- Browne S, Pandit A. Biomaterial-Mediated Mdification of the Local Inflammatory Environment, Front. Bioeng. Biotechnol., Vol. 3, 2015, pp.67.
- Sönmez M, Verisan C, Voicu G, Ficai D, Ficai A, Oprea A E, Vlad M, Andronescu E. Extended Release of Vitamins From Magnetite Loaded Polyanionic Polymeric Beads, Int. J. Pharm., 2015.
- Bunkoed O, Kanatharana P. Extraction of Polycyclic Aromatic Hydrocarbons with a Magnetic Sorbent Composed of Alginate, Magnetite Nanoparticles and Multiwalled Carbon Nanotubes, Microchim. Acta, Vol. 182, No. 7–8, 2015, pp.1519–1526.
- Ben Hammouda S, Adhoum N, Monser L. Synthesis of Magnetic Alginate Beads Based on Fe3O4 Nanoparticles for the Removal of 3-methylindole From Aqueous Solution Using Fenton Process, J. Hazard. Mater., Vol. 294, 2015, pp.128–136.
- Obeid L, El Kolli N, Talbot D, Welschbillig M, Bée A. Influence of a Cationic Surfactant on Adsorption of P-nitrophenol by a Magsorbent Based on Magnetic Alginate Beads, J. Colloid Interface Sci., Vol. 457, 2015, pp.218–224.
- Cushen M, Kerry J, Morris M, Cruz-Romero M, Cummins E. Nanotechnologies in the Food Industry-Recent Developments, Risks and Regulation, Trends Food Sci. Technol., Vol. 24, No. 1, 2012, pp.30–46.
- Hu K, Huang X, Gao Y, Huang X, Xiao H, McClements DJ. Core-Shell Biopolymer Nanoparticle Delivery Systems: Synthesis and Characterization of Curcumin Fortified Zein-Pectin Nanoparticles., Food Chem., Vol. 182, 2015, pp.275–281.
- Arroyo-Maya IJ, McClements DJ. Biopolymer Nanoparticles as Potential Delivery Systems for Anthocyanins: Fabrication and Properties,” Food Res. Int., Vol. 69, 2015, pp.1–8.
- Ruiz-Hitzky E, Darder M. Aranda P. Functional Biopolymer Nanocomposites Based on Layered Solids, J. Mater. Chem., Vol. 15, No. 35–36, 2005, pp.3650.
- Kondaveeti S, Cornejo DR, Petri DFS. Alginate/Magnetite Hybrid Beads for Magnetically Stimulated Release of Dopamine, Colloids Surf. B. Biointerfaces, Vol. 138, 2016, pp.94–101.
- Xiao C, You R, Fan Y, Zhang Y. Tunable Functional Hydrogels Formed from a Versatile Water-Soluble Chitosan, Int. J. Biol. Macromol., Vol. 85, 2016, pp.386–390.
- Finotelli PV, Da Silva D, Sola-Penna M, Rossi AM, Farina M, Andrade LR, Takeuchi AY, Rocha-Leão MH. Microcapsules of Alginate/Chitosan Containing Magnetic Nanoparticles for Controlled Release of Insulin, Colloids Surf. B. Biointerfaces, Vol. 81, No. 1, 2010, pp.206–211.
- Park ES, Maniar M, Shah JC. Biodegradable Polyanhydride Devices of Cefazolin Sodium, Bupivacaine, and Taxol for Local Drug Delivery: Preparation, and Kinetics and Mechanism of in Vitro Release, J. Control. Release, Vol. 52, No. 1–2, 1998, pp.179–189.
- Wang G, Liu SJ, Using SWN, Chan EC, The Release of Cefazolin and Gentamicin from Biodegradable PLA/PGA Beads., Int. J. Pharm., Vol. 273, No. 1–2, 2004, pp.203-212
UYARANLARA KARŞI DUYARLI, MANYETİK NANOPARÇACIK İÇERİKLİ HİDROJELLERİN ANTİ-ENFLAMATUAR İLAÇ TAŞIYICISI OLARAK KULLANIMI
Abstract
Bu çalışmada, manyetik aljinant taneleri, Süperparamanyetik demir oksit (Fe3O4) nanoparçacıkların, sentez sırasında sodyum aljinat mikrotaneleri içerisine entegre edilmesi ile sentezlenmiştir. Elde edildiği haliyle kurutulan örnekler, su tutma kapasiteleri ve ilaç enkapsülasyon verimliliği açısından analiz edilmiştir. Ayrıca, genellikle ameliyat sonrası eklem iltihaplanmalarının tedavisinde kullanılan bir anti inflamatuar ilaç (Sefazol), manyetik alan altında mikrokompozitlerin uyaranlara duyarlılık özelliklerinin değerlendirilmesi için model ilaç olarak kullanılmıştır. Bunun için, pH, sıcaklık ve manyetik alan gibi değişen ortam koşullarındaki ilaç salım kinetikleri incelenmiş ve boş aljinat taneleri ile karşılaştırılmıştır
References
- Bhatia D, Bejarano T, Novo M. Current Interventions in the Management of Knee Osteoarthritis, J. Pharm. Bioallied Sci., Vol. 5, No. 1, 2013, pp.30–38.
- Browne S, Pandit A. Biomaterial-Mediated Mdification of the Local Inflammatory Environment, Front. Bioeng. Biotechnol., Vol. 3, 2015, pp.67.
- Sönmez M, Verisan C, Voicu G, Ficai D, Ficai A, Oprea A E, Vlad M, Andronescu E. Extended Release of Vitamins From Magnetite Loaded Polyanionic Polymeric Beads, Int. J. Pharm., 2015.
- Bunkoed O, Kanatharana P. Extraction of Polycyclic Aromatic Hydrocarbons with a Magnetic Sorbent Composed of Alginate, Magnetite Nanoparticles and Multiwalled Carbon Nanotubes, Microchim. Acta, Vol. 182, No. 7–8, 2015, pp.1519–1526.
- Ben Hammouda S, Adhoum N, Monser L. Synthesis of Magnetic Alginate Beads Based on Fe3O4 Nanoparticles for the Removal of 3-methylindole From Aqueous Solution Using Fenton Process, J. Hazard. Mater., Vol. 294, 2015, pp.128–136.
- Obeid L, El Kolli N, Talbot D, Welschbillig M, Bée A. Influence of a Cationic Surfactant on Adsorption of P-nitrophenol by a Magsorbent Based on Magnetic Alginate Beads, J. Colloid Interface Sci., Vol. 457, 2015, pp.218–224.
- Cushen M, Kerry J, Morris M, Cruz-Romero M, Cummins E. Nanotechnologies in the Food Industry-Recent Developments, Risks and Regulation, Trends Food Sci. Technol., Vol. 24, No. 1, 2012, pp.30–46.
- Hu K, Huang X, Gao Y, Huang X, Xiao H, McClements DJ. Core-Shell Biopolymer Nanoparticle Delivery Systems: Synthesis and Characterization of Curcumin Fortified Zein-Pectin Nanoparticles., Food Chem., Vol. 182, 2015, pp.275–281.
- Arroyo-Maya IJ, McClements DJ. Biopolymer Nanoparticles as Potential Delivery Systems for Anthocyanins: Fabrication and Properties,” Food Res. Int., Vol. 69, 2015, pp.1–8.
- Ruiz-Hitzky E, Darder M. Aranda P. Functional Biopolymer Nanocomposites Based on Layered Solids, J. Mater. Chem., Vol. 15, No. 35–36, 2005, pp.3650.
- Kondaveeti S, Cornejo DR, Petri DFS. Alginate/Magnetite Hybrid Beads for Magnetically Stimulated Release of Dopamine, Colloids Surf. B. Biointerfaces, Vol. 138, 2016, pp.94–101.
- Xiao C, You R, Fan Y, Zhang Y. Tunable Functional Hydrogels Formed from a Versatile Water-Soluble Chitosan, Int. J. Biol. Macromol., Vol. 85, 2016, pp.386–390.
- Finotelli PV, Da Silva D, Sola-Penna M, Rossi AM, Farina M, Andrade LR, Takeuchi AY, Rocha-Leão MH. Microcapsules of Alginate/Chitosan Containing Magnetic Nanoparticles for Controlled Release of Insulin, Colloids Surf. B. Biointerfaces, Vol. 81, No. 1, 2010, pp.206–211.
- Park ES, Maniar M, Shah JC. Biodegradable Polyanhydride Devices of Cefazolin Sodium, Bupivacaine, and Taxol for Local Drug Delivery: Preparation, and Kinetics and Mechanism of in Vitro Release, J. Control. Release, Vol. 52, No. 1–2, 1998, pp.179–189.
- Wang G, Liu SJ, Using SWN, Chan EC, The Release of Cefazolin and Gentamicin from Biodegradable PLA/PGA Beads., Int. J. Pharm., Vol. 273, No. 1–2, 2004, pp.203-212
Details
| Other ID | JA49MH63AC |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 1, 2016 |
| Published in Issue | Year 2016 Volume: 18 Issue: 52 |
Cite
Dokuz Eylül Üniversitesi, Mühendislik Fakültesi Dekanlığı Tınaztepe Yerleşkesi, Adatepe Mah. Doğuş Cad. No: 207-I / 35390 Buca-İZMİR.