Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer

Onur Yazdan Balçık; Yusuf İlhan; Bilgin Demir

doi:10.5798/dicletip.1266716

Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer

Abstract

Objectives: Pancreatic cancer (PC) is one of the cancers with the worst prognosis in the world. Despite protooncogenes such as BRCA and PALB2 , effective, inexpensive, and simple methods for predicting the prognosis of patients with metastatic PC are still lacking. We aim to investigate whether mean platelet volume/ platelet (MPV/PLT) and platelet indices such as MPV and plateletcrit (PCT) have a prognostic significance in patients with metastatic PC. Methods: Patients diagnosed with metastatic PC in 3 centers in Turkey between 2016 and 2022 were analyzed retrospectively. We recorded patient’s demographic data such as age, gender, performance status and platelet, MPV and PCT. Overall survival (OS) and progression-free survival (PFS) were also recorded. There were 80 patients in our study. Results: Median PFS was found 6.2 months for MPV/PLT ratio <0.045 group and 6.3 months for MPV/PLT ratio >0.045 group retrospectively. The median PFS of the MPV/PLT ratio ≤0.045 groupwas shorter than MPV/PLT ratio >0.045 group, but there wasn’t statistically meaningful difference between the groups (p:0,957). Median OS for the MPV/PLT ratio ≤0.045 groupwas 10.1 months and the MPV/PLT ratio for the >0.045 group was 9 months, but there wasn’t statistically significant difference between the groups (p:0.506).There was nosurvival difference between the groups when comparing both MPV and PCT status. Conclusion: MPV/PLT ratio is a cheap, simple and useful marker and can be used in our daily practice to predict the prognosis of patients with advanced PC, if confirmed by prospective studies and larger patient numbers.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Onur Yazdan Balçık ^* This is me
Türkiye

Yusuf İlhan This is me
Türkiye

Bilgin Demir This is me
Türkiye

Publication Date

March 19, 2023

Submission Date

October 29, 2022

Acceptance Date

February 28, 2023

Published in Issue

Year 2023 Volume: 50 Number: 1

DOI

https://doi.org/10.5798/dicletip.1266716

IZ

https://izlik.org/JA48HN48GH

Cite

RIS / Bibtex

APA

Balçık, O. Y., İlhan, Y., & Demir, B. (2023). Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Medical Journal, 50(1), 51-59. https://doi.org/10.5798/dicletip.1266716

AMA

1.Balçık OY, İlhan Y, Demir B. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Medical Journal. 2023;50(1):51-59. doi:10.5798/dicletip.1266716

Chicago

Balçık, Onur Yazdan, Yusuf İlhan, and Bilgin Demir. 2023. “Prognostic Importance of Mean Platelet Volume Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Medical Journal 50 (1): 51-59. https://doi.org/10.5798/dicletip.1266716.

EndNote

Balçık OY, İlhan Y, Demir B (March 1, 2023) Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Medical Journal 50 1 51–59.

IEEE

[1]O. Y. Balçık, Y. İlhan, and B. Demir, “Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer”, Dicle Medical Journal, vol. 50, no. 1, pp. 51–59, Mar. 2023, doi: 10.5798/dicletip.1266716.

ISNAD

Balçık, Onur Yazdan - İlhan, Yusuf - Demir, Bilgin. “Prognostic Importance of Mean Platelet Volume Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Medical Journal 50/1 (March 1, 2023): 51-59. https://doi.org/10.5798/dicletip.1266716.

JAMA

1.Balçık OY, İlhan Y, Demir B. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Medical Journal. 2023;50:51–59.

MLA

Balçık, Onur Yazdan, et al. “Prognostic Importance of Mean Platelet Volume Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Medical Journal, vol. 50, no. 1, Mar. 2023, pp. 51-59, doi:10.5798/dicletip.1266716.

Vancouver

1.Onur Yazdan Balçık, Yusuf İlhan, Bilgin Demir. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Medical Journal. 2023 Mar. 1;50(1):51-9. doi:10.5798/dicletip.1266716