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Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer

Yıl 2023, , 51 - 59, 19.03.2023
https://doi.org/10.5798/dicletip.1266716

Öz

Objectives: Pancreatic cancer (PC) is one of the cancers with the worst prognosis in the world. Despite protooncogenes such as BRCA and PALB2 , effective, inexpensive, and simple methods for predicting the prognosis of patients with metastatic PC are still lacking. We aim to investigate whether mean platelet volume/ platelet (MPV/PLT) and platelet indices such as MPV and plateletcrit (PCT) have a prognostic significance in patients with metastatic PC.
Methods: Patients diagnosed with metastatic PC in 3 centers in Turkey between 2016 and 2022 were analyzed retrospectively. We recorded patient’s demographic data such as age, gender, performance status and platelet, MPV and PCT. Overall survival (OS) and progression-free survival (PFS) were also recorded. There were 80 patients in our study.
Results: Median PFS was found 6.2 months for MPV/PLT ratio <0.045 group and 6.3 months for MPV/PLT ratio >0.045 group retrospectively. The median PFS of the MPV/PLT ratio ≤0.045 groupwas shorter than MPV/PLT ratio >0.045 group, but there wasn’t statistically meaningful difference between the groups (p:0,957). Median OS for the MPV/PLT ratio ≤0.045 groupwas 10.1 months and the MPV/PLT ratio for the >0.045 group was 9 months, but there wasn’t statistically significant difference between the groups (p:0.506).There was nosurvival difference between the groups when comparing both MPV and PCT status.
Conclusion: MPV/PLT ratio is a cheap, simple and useful marker and can be used in our daily practice to predict the prognosis of patients with advanced PC, if confirmed by prospective studies and larger patient numbers.

Kaynakça

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Toplam 4 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Original Articles
Yazarlar

Onur Yazdan Balçık Bu kişi benim

Yusuf İlhan Bu kişi benim

Bilgin Demir Bu kişi benim

Yayımlanma Tarihi 19 Mart 2023
Gönderilme Tarihi 29 Ekim 2022
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

APA Balçık, O. Y., İlhan, Y., & Demir, B. (2023). Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Tıp Dergisi, 50(1), 51-59. https://doi.org/10.5798/dicletip.1266716
AMA Balçık OY, İlhan Y, Demir B. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. diclemedj. Mart 2023;50(1):51-59. doi:10.5798/dicletip.1266716
Chicago Balçık, Onur Yazdan, Yusuf İlhan, ve Bilgin Demir. “Prognostic Importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Tıp Dergisi 50, sy. 1 (Mart 2023): 51-59. https://doi.org/10.5798/dicletip.1266716.
EndNote Balçık OY, İlhan Y, Demir B (01 Mart 2023) Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. Dicle Tıp Dergisi 50 1 51–59.
IEEE O. Y. Balçık, Y. İlhan, ve B. Demir, “Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer”, diclemedj, c. 50, sy. 1, ss. 51–59, 2023, doi: 10.5798/dicletip.1266716.
ISNAD Balçık, Onur Yazdan vd. “Prognostic Importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Tıp Dergisi 50/1 (Mart 2023), 51-59. https://doi.org/10.5798/dicletip.1266716.
JAMA Balçık OY, İlhan Y, Demir B. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. diclemedj. 2023;50:51–59.
MLA Balçık, Onur Yazdan vd. “Prognostic Importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients With Metastatic Pancreatic Cancer”. Dicle Tıp Dergisi, c. 50, sy. 1, 2023, ss. 51-59, doi:10.5798/dicletip.1266716.
Vancouver Balçık OY, İlhan Y, Demir B. Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer. diclemedj. 2023;50(1):51-9.