Comparison of the Clinical Features and Prognostic Value of Inflammation-Based Markers in Uterine Leiomyosarcoma

Abstract

Aim: Inflammation-related markers are the factors affecting prognosis in many types of cancer. In this study, we aimed to investigate the relationship between inflammation-related markers, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and prognostic nutritional index (PNI) with prognosis of patients with uterine leiomyosarcoma (uLMS). Methods: Patients diagnosed with uLMS were reviewed retrospectively. NLR, PLR, SII, and PNI values were calculated at the diagnosis and before treatment. Totally 35 patients were included in the study. Results: Median overall survival (OS) in the low-NLR (<2.10) group was not reached using Kaplan-Meier analysis, whereas in the high-NLR (≥2.10) group, median OS was 41.6 months (95% CI:25.7 – 57.4) (p=0.019). Median OS in the low-PLR (<145) group could not be reached using Kaplan-Meier analysis, whereas, in the high-PLR (≥145) group, the median OS was 43.0 months (95% CI:21.9 – 64.1) (p=0.046). The median OS was 107.7 months (confidence interval not reached using Kaplan-Meier analysis) in the low-SII (<806) group, while the median OS was 43.0 months (95% CI:23.7 – 62.3) in the high-SII (≥806) group (p=0.039). In the low-PNI, (<53.7) group, the median OS was 53.2 months (95% CI:20.8 – 90.9), while in the high-PNI (≥53.7) group, the median OS was 41.6 months (0 – 94.0) (p=0.652). In multivariate analysis, mitotic count and NLR were observed as independent factors affecting prognosis in OS (p=0.012 and p=0.035). Conclusions: NLR≥2.10 is an independent marker showing a poor prognosis in uLMS patients.

Keywords

• Neutrophil-lymphocyte ratio
• uterine leiomyosarcoma
• survival
• prognosis

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