Travma Sonrası Stres Bozukluğu Hastalarında İnterlökin-4, İnterlökin-17, İnterferon-Gama ve Beyaz Kan Hücre Düzeyleri ile Sosyodemografik Özelliklerin İncelenmesi

Abstract

Amaç: Bu çalışmada, travma sonrası stres bozukluğu (TSSB) tanısı alan bireylerde interlökin-4 (IL-4), interlökin-17(IL-17), interferon gama (IFN-γ) ve beyaz kan hücre düzeylerinin incelenmesi, bu biyobelirteçlerle ile sosyodemografik ve klinik özellikler arasındaki ilişkilerin değerlendirilmesi amaçlanmıştır. Yöntemler: Çalışmaya 6 Şubat 2023 Kahramanmaraş merkezli depremlerin ardından 01.06.2023 ile 31.01.2024 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Psikiyatri Polikliniği’ne başvuran, DSM-5-TR kriterlerine göre TSSB tanısı konulan 18-65 yaş arası 53 hasta, kontrol grubu olarak yaş ile cinsiyet açısından eşleştirilmiş ve benzer sosyodemografik özelliklere sahip olan herhangi bir psikiyatrik hastalığı olmayan 53 sağlıklı birey dahil edilmiştir. Katılımcılardan alınan kan örneklerinde IL-4, IL-17 ve IFN-γ düzeyleri ELISA (Enzyme-Linked Immunosorbent Assay) yöntemiyle üretici firmanın protokollerine uygun olarak ticari kitler kullanılarak ölçülmüştür (Sunred Biotechnology Company, Çin). WBC düzeyleri Sysmex XN-1000 marka tam kan sayımı cihazıyla (Sysmex Corporation, Japonya) analiz edilmiştir. Tüm katılımcılara sosyodemografik veri formu, Klinik Global İzlenim Ölçeği (CGI), Travma Sonrası Stres Bozukluğu Kısa Ölçeği (TSSB-KÖ), Hamilton Anksiyete Değerlendirme Ölçeği (HAM-A) ve Hamilton Depresyon Değerlendirme Ölçeği (HAM-D) uygulanmıştır. Bulgular: Vaka ve kontrol grupları arasında hemogram parametreleri ile IL-4, IL-17 ve IFN-γ düzeylerinde istatistiksel olarak anlamlı fark bulunmamıştır. Ancak TSSB’li bireylerde eğitim süresi, medeni durum, çocuk sahibi olma, çalışma durumu, gelir durumu ve evi hasar gören yakını bulunma gibi sosyodemografik özellikler ile klinik ölçek puanları açısından istatistiksel olarak fark bulunmuştur. Sonuç: Bu çalışma ile deprem sonrası TSSB’de sosyoekonomik faktörlerin, yakın çevredeki hasar düzeyinin, eşlik eden depresyon ve anksiyete belirtilerinin ilişkileri ortaya konmuştur.

Keywords

• Travma sonrası stres bozukluğu
• İnterlökin-4
• İnterlökin-17
• İnterferon gama
• Sosyodemografik özellikler

Investigation of the Relationship Between Interleukin-4, Interleukin-17, Interferon-Gamma, And white Blood Cell (Wbc) Levels and Sociodemographic Characteristics in Patients with Posttraumatic Stress Disorder

Abstract

Objective: This study aimed to investigate the levels of interleukin-4 (IL-4), interleukin-17 (IL-17), interferon-gamma (IFN-γ), and white blood cells (WBC) in individuals diagnosed with post-traumatic stress disorder (PTSD) and to evaluate the relationships between these biomarkers and sociodemographic as well as clinical characteristics. Methods: The study included 53 patients aged between 18 and 65 years who were diagnosed with post-traumatic stress disorder (PTSD) according to DSM-5-TR criteria and who applied to the Psychiatry Outpatient Clinic of Dicle University Faculty of Medicine between June 1, 2023 and January 31, 2024, after the February 6, 2023 Kahramanmaraş-centered earthquakes. The control group comprised 53 healthy individuals with no history of psychiatric illness, matched to the patient group by age and sex and with comparable sociodemographic characteristics. Serum levels of IL-4, IL-17, and IFN-γ were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) method with commercial kits according to the manufacturer’s protocols (Sunred Biological Technology Co., Ltd., China). WBC levels were analyzed using a Sysmex XN-1000 automated hematology analyzer (Sysmex Corporation, Japan). All participants were assessed using a sociodemographic data form, the Clinical Global Impression Scale (CGI), the Posttraumatic Stress Disorder Short Scale (PTSD-SS), the Hamilton Anxiety Rating Scale (HAM-A), and the Hamilton Depression Rating Scale (HAM-D). Results: No statistically significant differences were found between the patient and control groups in terms of hemogram parameters and IL-4, IL-17, and IFN-γ levels. However, statistically significant differences were found in sociodemographic characteristics such as educational level, marital status, having children, employment status, income level, and having relatives whose homes were damaged, as well as in clinical scale scores among individuals with PTSD. Conclusion: This study demonstrated the associations between socioeconomic factors, the degree of environmental damage, and accompanying depressive and anxiety symptoms in post-earthquake PTSD.

Keywords

• Post-traumatic stress disorder
• Interleukin-4; Interleukin-17; Interferon-gamma
• Sociodemographic characteristics

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