The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels

Hüsnü Alptekin; Nazife Alptekin; Hatice Işık; Yusuf Tanrıkulu; Emel Şahin

doi:10.5798/diclemedj.0921.2016.01.0647

The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels

Abstract

Objective: Brain derived neurotrophic factor (BDNF) is the most important neurotrophin, which helps the differentiation and growth of central and peripheral neurons, and facilitates synaptic transmission. In this study we aimed to investigate fetal cord BDNF levels of infants born from subclinical and clinical maternal hypothyroidism.
Methods: This study was conducted on a total of 67 pregnant women who were followed up in Obstetrics and Gynecology outpatient clinics, 27 with maternal hypothyroidism and 40 age-parity matched healthy pregnants without hypothyroidism. Immediately after vaginal or cesarean delivery fetal cord blood samples were taken from these patients and BDNF levels were measured.
Results: BDNF levels of infants born from pregnants with maternal hypothyroidism were significantly lower than the control group (23.3 ± 17.4 ng/dl and 50.7 ± 28.3 ng/dl respectively; p<0.001). In multiple linear regression analysis, while BDNF level was related with maternal hypothyroidism and infant sex, it was not associated with mode of delivery, maternal age, total weight gain during pregnancy, gestational age at birth, thyroid stimulating hormone (TSH) levels and other neonatal data.
Conclusion: This study showed that fetal cord BDNF levels significantly decreased in infants of the pregnants with hypothyroidism.
Key words: Pregnancy, maternal hypothyroidism, brain derived neurotrophic factor, levothyroxine

Keywords

Gebelik, maternal hipotiroidi, beyin kaynaklı nörotrofik faktör (BDNF), levotiroksin

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Hüsnü Alptekin

Nazife Alptekin This is me

Hatice Işık This is me

Yusuf Tanrıkulu This is me

Emel Şahin This is me

Publication Date

March 1, 2016

Submission Date

March 29, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 43 Number: 1

DOI

https://doi.org/10.5798/diclemedj.0921.2016.01.0647

IZ

https://izlik.org/JA45SD65EA

Cite

RIS / Bibtex

APA

Alptekin, H., Alptekin, N., Işık, H., Tanrıkulu, Y., & Şahin, E. (2016). The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal, 43(1), 107-111. https://doi.org/10.5798/diclemedj.0921.2016.01.0647

AMA

1.Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal. 2016;43(1):107-111. doi:10.5798/diclemedj.0921.2016.01.0647

Chicago

Alptekin, Hüsnü, Nazife Alptekin, Hatice Işık, Yusuf Tanrıkulu, and Emel Şahin. 2016. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal 43 (1): 107-11. https://doi.org/10.5798/diclemedj.0921.2016.01.0647.

EndNote

Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E (March 1, 2016) The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal 43 1 107–111.

IEEE

[1]H. Alptekin, N. Alptekin, H. Işık, Y. Tanrıkulu, and E. Şahin, “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”, Dicle Medical Journal, vol. 43, no. 1, pp. 107–111, Mar. 2016, doi: 10.5798/diclemedj.0921.2016.01.0647.

ISNAD

Alptekin, Hüsnü - Alptekin, Nazife - Işık, Hatice - Tanrıkulu, Yusuf - Şahin, Emel. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal 43/1 (March 1, 2016): 107-111. https://doi.org/10.5798/diclemedj.0921.2016.01.0647.

JAMA

1.Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal. 2016;43:107–111.

MLA

Alptekin, Hüsnü, et al. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal, vol. 43, no. 1, Mar. 2016, pp. 107-11, doi:10.5798/diclemedj.0921.2016.01.0647.

Vancouver

1.Hüsnü Alptekin, Nazife Alptekin, Hatice Işık, Yusuf Tanrıkulu, Emel Şahin. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal. 2016 Mar. 1;43(1):107-11. doi:10.5798/diclemedj.0921.2016.01.0647

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