The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels

Hüsnü Alptekin; Nazife Alptekin; Hatice Işık; Yusuf Tanrıkulu; Emel Şahin

doi:10.5798/diclemedj.0921.2016.01.0647

The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels

Öz

Objective: Brain derived neurotrophic factor (BDNF) is the most important neurotrophin, which helps the differentiation and growth of central and peripheral neurons, and facilitates synaptic transmission. In this study we aimed to investigate fetal cord BDNF levels of infants born from subclinical and clinical maternal hypothyroidism.
Methods: This study was conducted on a total of 67 pregnant women who were followed up in Obstetrics and Gynecology outpatient clinics, 27 with maternal hypothyroidism and 40 age-parity matched healthy pregnants without hypothyroidism. Immediately after vaginal or cesarean delivery fetal cord blood samples were taken from these patients and BDNF levels were measured.
Results: BDNF levels of infants born from pregnants with maternal hypothyroidism were significantly lower than the control group (23.3 ± 17.4 ng/dl and 50.7 ± 28.3 ng/dl respectively; p<0.001). In multiple linear regression analysis, while BDNF level was related with maternal hypothyroidism and infant sex, it was not associated with mode of delivery, maternal age, total weight gain during pregnancy, gestational age at birth, thyroid stimulating hormone (TSH) levels and other neonatal data.
Conclusion: This study showed that fetal cord BDNF levels significantly decreased in infants of the pregnants with hypothyroidism.
Key words: Pregnancy, maternal hypothyroidism, brain derived neurotrophic factor, levothyroxine

Anahtar Kelimeler

Gebelik, maternal hipotiroidi, beyin kaynaklı nörotrofik faktör (BDNF), levotiroksin

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Hüsnü Alptekin

Nazife Alptekin Bu kişi benim

Hatice Işık Bu kişi benim

Yusuf Tanrıkulu Bu kişi benim

Emel Şahin Bu kişi benim

Yayımlanma Tarihi

1 Mart 2016

Gönderilme Tarihi

29 Mart 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 43 Sayı: 1

DOI

https://doi.org/10.5798/diclemedj.0921.2016.01.0647

IZ

https://izlik.org/JA45SD65EA

Kaynak Göster

RIS / Bibtex

APA

Alptekin, H., Alptekin, N., Işık, H., Tanrıkulu, Y., & Şahin, E. (2016). The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal, 43(1), 107-111. https://doi.org/10.5798/diclemedj.0921.2016.01.0647

AMA

1.Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. diclemedj. 2016;43(1):107-111. doi:10.5798/diclemedj.0921.2016.01.0647

Chicago

Alptekin, Hüsnü, Nazife Alptekin, Hatice Işık, Yusuf Tanrıkulu, ve Emel Şahin. 2016. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal 43 (1): 107-11. https://doi.org/10.5798/diclemedj.0921.2016.01.0647.

EndNote

Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E (01 Mart 2016) The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. Dicle Medical Journal 43 1 107–111.

IEEE

[1]H. Alptekin, N. Alptekin, H. Işık, Y. Tanrıkulu, ve E. Şahin, “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”, diclemedj, c. 43, sy 1, ss. 107–111, Mar. 2016, doi: 10.5798/diclemedj.0921.2016.01.0647.

ISNAD

Alptekin, Hüsnü - Alptekin, Nazife - Işık, Hatice - Tanrıkulu, Yusuf - Şahin, Emel. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal 43/1 (01 Mart 2016): 107-111. https://doi.org/10.5798/diclemedj.0921.2016.01.0647.

JAMA

1.Alptekin H, Alptekin N, Işık H, Tanrıkulu Y, Şahin E. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. diclemedj. 2016;43:107–111.

MLA

Alptekin, Hüsnü, vd. “The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels”. Dicle Medical Journal, c. 43, sy 1, Mart 2016, ss. 107-11, doi:10.5798/diclemedj.0921.2016.01.0647.

Vancouver

1.Hüsnü Alptekin, Nazife Alptekin, Hatice Işık, Yusuf Tanrıkulu, Emel Şahin. The Effect of Maternal Hypothyroidism on Fetal Umbilical Cord Brain-Derived Neurotrophic Factor Levels. diclemedj. 01 Mart 2016;43(1):107-11. doi:10.5798/diclemedj.0921.2016.01.0647

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