The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes

Mehmet Türken; Sedat Yılmaz; Leyla Çolpan; Belkis Aydınol; Alpaslan Tuzcu

doi:10.5798/diclemedj.0921.2015.04.0604

The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes

Abstract

Objective: The aim of this study was to investigate the role of vitamin D deficiency in DMT1 pathogenesis by examining the effects of vitamin D levels on immune modulatory cytokines in patients with DMT1.

Methods: Thirty adults with DMT1 from the endocrine clinic and 30 healthy controls were included in the study. Measurements for 25-hydroxyvitamin D (25OHD), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels were obtained from serum samples from each study participant. Measurements were compared between the control group and the patient group. Correlations between 25OHD levels and the levels of sIL-2R, IL-6, and TNF-α cytokines were investigated in patients with DMT1.

Results: The mean 25OHD value for the DMT1 patients was significantly lower than for the control group (14.9±9.8 ng/ml versus 24.8±9.4 ng/ml, respectively; p<0.01). The mean sIL-2R and TNF-α scores for patients with DMT1 were significantly higher than for the control group (707.3 ± 265 U/mL versus 403.1 ± 128 U/mL, respectively; p<0.01; and 10.2±3.0 pg/mL versus 3.8 ± 1.6 pg/mL, respectively; p<0.01). There was no significant difference between the mean IL-6 scores of the DMT1 patients and the controls (3.7±1.5 pg/mL versus 4.6±1.3 pg/mL, respectively; p=0,202). Negative correlations with varying levels of significance were observed between 25OHD and sIL-2R, IL-6, and TNF-α cytokine levels in patients with DMT1.

Conclusion: Vitamin D deficiency in DMT1 patients may contribute to disease pathogenesis by increasing sIL-2R, IL-6, and TNF-α cytokines.

Key words: Diabetes mellitus type 1, vitamin D deficiency, soluble interleukin-2 receptor, interleukin-6, tumor necrosis factor-α

Keywords

Tip1 diyabetes mellitus, D vitamini eksikliği, solubl interlökin-2 reseptör, interlökin-6, tümör nekrozis faktör alfa-α

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Mehmet Türken This is me

Sedat Yılmaz

Leyla Çolpan This is me

Belkis Aydınol This is me

Alpaslan Tuzcu This is me

Publication Date

January 8, 2016

Submission Date

January 8, 2016

Acceptance Date

-

Published in Issue

Year 2015 Volume: 42 Number: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.04.0604

IZ

https://izlik.org/JA28WD44WL

Cite

RIS / Bibtex

APA

Türken, M., Yılmaz, S., Çolpan, L., Aydınol, B., & Tuzcu, A. (2016). The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal, 42(4), 432-437. https://doi.org/10.5798/diclemedj.0921.2015.04.0604

AMA

1.Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal. 2016;42(4):432-437. doi:10.5798/diclemedj.0921.2015.04.0604

Chicago

Türken, Mehmet, Sedat Yılmaz, Leyla Çolpan, Belkis Aydınol, and Alpaslan Tuzcu. 2016. “The Effect of Vitamin D Deficiency on Serum SIL-2R, IL-6 and TNF-Alpha Levels in Adults With Type 1 Diabetes”. Dicle Medical Journal 42 (4): 432-37. https://doi.org/10.5798/diclemedj.0921.2015.04.0604.

EndNote

Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A (January 1, 2016) The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal 42 4 432–437.

IEEE

[1]M. Türken, S. Yılmaz, L. Çolpan, B. Aydınol, and A. Tuzcu, “The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes”, Dicle Medical Journal, vol. 42, no. 4, pp. 432–437, Jan. 2016, doi: 10.5798/diclemedj.0921.2015.04.0604.

ISNAD

Türken, Mehmet - Yılmaz, Sedat - Çolpan, Leyla - Aydınol, Belkis - Tuzcu, Alpaslan. “The Effect of Vitamin D Deficiency on Serum SIL-2R, IL-6 and TNF-Alpha Levels in Adults With Type 1 Diabetes”. Dicle Medical Journal 42/4 (January 1, 2016): 432-437. https://doi.org/10.5798/diclemedj.0921.2015.04.0604.

JAMA

1.Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal. 2016;42:432–437.

MLA

Türken, Mehmet, et al. “The Effect of Vitamin D Deficiency on Serum SIL-2R, IL-6 and TNF-Alpha Levels in Adults With Type 1 Diabetes”. Dicle Medical Journal, vol. 42, no. 4, Jan. 2016, pp. 432-7, doi:10.5798/diclemedj.0921.2015.04.0604.

Vancouver

1.Mehmet Türken, Sedat Yılmaz, Leyla Çolpan, Belkis Aydınol, Alpaslan Tuzcu. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal. 2016 Jan. 1;42(4):432-7. doi:10.5798/diclemedj.0921.2015.04.0604