The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes

Mehmet Türken; Sedat Yılmaz; Leyla Çolpan; Belkis Aydınol; Alpaslan Tuzcu

doi:10.5798/diclemedj.0921.2015.04.0604

The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes

Öz

Objective: The aim of this study was to investigate the role of vitamin D deficiency in DMT1 pathogenesis by examining the effects of vitamin D levels on immune modulatory cytokines in patients with DMT1.

Methods: Thirty adults with DMT1 from the endocrine clinic and 30 healthy controls were included in the study. Measurements for 25-hydroxyvitamin D (25OHD), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels were obtained from serum samples from each study participant. Measurements were compared between the control group and the patient group. Correlations between 25OHD levels and the levels of sIL-2R, IL-6, and TNF-α cytokines were investigated in patients with DMT1.

Results: The mean 25OHD value for the DMT1 patients was significantly lower than for the control group (14.9±9.8 ng/ml versus 24.8±9.4 ng/ml, respectively; p<0.01). The mean sIL-2R and TNF-α scores for patients with DMT1 were significantly higher than for the control group (707.3 ± 265 U/mL versus 403.1 ± 128 U/mL, respectively; p<0.01; and 10.2±3.0 pg/mL versus 3.8 ± 1.6 pg/mL, respectively; p<0.01). There was no significant difference between the mean IL-6 scores of the DMT1 patients and the controls (3.7±1.5 pg/mL versus 4.6±1.3 pg/mL, respectively; p=0,202). Negative correlations with varying levels of significance were observed between 25OHD and sIL-2R, IL-6, and TNF-α cytokine levels in patients with DMT1.

Conclusion: Vitamin D deficiency in DMT1 patients may contribute to disease pathogenesis by increasing sIL-2R, IL-6, and TNF-α cytokines.

Key words: Diabetes mellitus type 1, vitamin D deficiency, soluble interleukin-2 receptor, interleukin-6, tumor necrosis factor-α

Anahtar Kelimeler

Tip1 diyabetes mellitus, D vitamini eksikliği, solubl interlökin-2 reseptör, interlökin-6, tümör nekrozis faktör alfa-α

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Mehmet Türken Bu kişi benim

Sedat Yılmaz

Leyla Çolpan Bu kişi benim

Belkis Aydınol Bu kişi benim

Alpaslan Tuzcu Bu kişi benim

Yayımlanma Tarihi

8 Ocak 2016

Gönderilme Tarihi

8 Ocak 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2015 Cilt: 42 Sayı: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.04.0604

IZ

https://izlik.org/JA28WD44WL

Kaynak Göster

RIS / Bibtex

APA

Türken, M., Yılmaz, S., Çolpan, L., Aydınol, B., & Tuzcu, A. (2016). The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal, 42(4), 432-437. https://doi.org/10.5798/diclemedj.0921.2015.04.0604

AMA

1.Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. diclemedj. 2016;42(4):432-437. doi:10.5798/diclemedj.0921.2015.04.0604

Chicago

Türken, Mehmet, Sedat Yılmaz, Leyla Çolpan, Belkis Aydınol, ve Alpaslan Tuzcu. 2016. “The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes”. Dicle Medical Journal 42 (4): 432-37. https://doi.org/10.5798/diclemedj.0921.2015.04.0604.

EndNote

Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A (01 Ocak 2016) The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. Dicle Medical Journal 42 4 432–437.

IEEE

[1]M. Türken, S. Yılmaz, L. Çolpan, B. Aydınol, ve A. Tuzcu, “The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes”, diclemedj, c. 42, sy 4, ss. 432–437, Oca. 2016, doi: 10.5798/diclemedj.0921.2015.04.0604.

ISNAD

Türken, Mehmet - Yılmaz, Sedat - Çolpan, Leyla - Aydınol, Belkis - Tuzcu, Alpaslan. “The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes”. Dicle Medical Journal 42/4 (01 Ocak 2016): 432-437. https://doi.org/10.5798/diclemedj.0921.2015.04.0604.

JAMA

1.Türken M, Yılmaz S, Çolpan L, Aydınol B, Tuzcu A. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. diclemedj. 2016;42:432–437.

MLA

Türken, Mehmet, vd. “The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes”. Dicle Medical Journal, c. 42, sy 4, Ocak 2016, ss. 432-7, doi:10.5798/diclemedj.0921.2015.04.0604.

Vancouver

1.Mehmet Türken, Sedat Yılmaz, Leyla Çolpan, Belkis Aydınol, Alpaslan Tuzcu. The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes. diclemedj. 01 Ocak 2016;42(4):432-7. doi:10.5798/diclemedj.0921.2015.04.0604