Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis

Ali Veysel Kara; Sema Tanrikulu; Emre Aydın; Fatma Aydın; Yaşar Yıldırım; Zülfükar Yılmaz; Ali Kemal Kadiroğlu; Mehmet Emin Yılmaz; Hikmet Soylu

doi:10.5798/dicletip.319769

Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis

Abstract

Objective: Acute kidney injury (AKI) is an important clinical entity that is known to increase mortality in patients with
sepsis. Erythrocyte maturation and proliferation are inhibited by pro-inflammatory cytokines; these cytokines exert
effects on red cell distribution width (RDW) well. Based on this knowledge; our aim in this study was to evaluate the
impact of RDW on acute kidney injury in patients with sepsis.
Methods: 120 patients diagnosed with sepsis and admitted to intesive care unit (ICU) and treated between 2009-2013
were retrospectively evaluated. Patients were divided into two groups as follows: group 1 (RDW≥16.8) and group 2
(RDW<16.8). Multiple logistic regression analysis was used to determine the association between RDW and AKI and
mortality.
Results: There was a statistically significant relationship between AKI and RDW (p<0.001, OR=11.52) but there were
no statistically significant relationship between AKI and sex, age, serum lactate levels as well as SOFA score. Also,
there were statistically significant relationship between mortality and RDW (p=0.044, OR=5), serum lactate levels
(p=0.030) and SOFA score (p<0.001). RDW was found associated with both AKI and mortality.
Conclusions: Results suggest that RDW is an important parameter for predicting development of AKI and mortality in
ICU patients with sepsis.

Keywords

Acute kidney injury,Sepsis

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Ali Veysel Kara This is me
Türkiye

Sema Tanrikulu This is me
Türkiye

Emre Aydın This is me
Türkiye

Fatma Aydın This is me
Türkiye

Yaşar Yıldırım This is me
Türkiye

Zülfükar Yılmaz This is me
Türkiye

Ali Kemal Kadiroğlu This is me
Türkiye

Mehmet Emin Yılmaz This is me
Türkiye

Hikmet Soylu This is me
Türkiye

Publication Date

June 7, 2017

Submission Date

June 7, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 44 Number: 2

DOI

https://doi.org/10.5798/dicletip.319769

IZ

https://izlik.org/JA85AD38ME

Cite

RIS / Bibtex

APA

Kara, A. V., Tanrikulu, S., Aydın, E., Aydın, F., Yıldırım, Y., Yılmaz, Z., Kadiroğlu, A. K., Yılmaz, M. E., & Soylu, H. (2017). Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis. Dicle Medical Journal, 44(2), 191-198. https://doi.org/10.5798/dicletip.319769

AMA

1.Kara AV, Tanrikulu S, Aydın E, et al. Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis. Dicle Medical Journal. 2017;44(2):191-198. doi:10.5798/dicletip.319769

Chicago

Kara, Ali Veysel, Sema Tanrikulu, Emre Aydın, et al. 2017. “Evaluation of the Effect of Red Cell Distribution Width on the Development of Acute Renal Failure in Patients With Sepsis”. Dicle Medical Journal 44 (2): 191-98. https://doi.org/10.5798/dicletip.319769.

EndNote

Kara AV, Tanrikulu S, Aydın E, Aydın F, Yıldırım Y, Yılmaz Z, Kadiroğlu AK, Yılmaz ME, Soylu H (June 1, 2017) Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis. Dicle Medical Journal 44 2 191–198.

IEEE

[1]A. V. Kara et al., “Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis”, Dicle Medical Journal, vol. 44, no. 2, pp. 191–198, June 2017, doi: 10.5798/dicletip.319769.

ISNAD

Kara, Ali Veysel - Tanrikulu, Sema - Aydın, Emre - Aydın, Fatma - Yıldırım, Yaşar - Yılmaz, Zülfükar - Kadiroğlu, Ali Kemal - Yılmaz, Mehmet Emin - Soylu, Hikmet. “Evaluation of the Effect of Red Cell Distribution Width on the Development of Acute Renal Failure in Patients With Sepsis”. Dicle Medical Journal 44/2 (June 1, 2017): 191-198. https://doi.org/10.5798/dicletip.319769.

JAMA

1.Kara AV, Tanrikulu S, Aydın E, Aydın F, Yıldırım Y, Yılmaz Z, Kadiroğlu AK, Yılmaz ME, Soylu H. Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis. Dicle Medical Journal. 2017;44:191–198.

MLA

Kara, Ali Veysel, et al. “Evaluation of the Effect of Red Cell Distribution Width on the Development of Acute Renal Failure in Patients With Sepsis”. Dicle Medical Journal, vol. 44, no. 2, June 2017, pp. 191-8, doi:10.5798/dicletip.319769.

Vancouver

1.Ali Veysel Kara, Sema Tanrikulu, Emre Aydın, Fatma Aydın, Yaşar Yıldırım, Zülfükar Yılmaz, Ali Kemal Kadiroğlu, Mehmet Emin Yılmaz, Hikmet Soylu. Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis. Dicle Medical Journal. 2017 Jun. 1;44(2):191-8. doi:10.5798/dicletip.319769

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Dicle Tıp Dergisi

https://doi.org/10.5798/dicletip.800278