Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Dursun Aygun; Cetin Kursad Akpinar; Serpil Yon; Musa Kazım Onar

doi:10.5798/dicletip.338976

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Abstract

Objective: Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. PD also involves nonmotor manifestations such as autonomic failure, cognitive disorders, and sleep disorders. These clinical characteristics are not identical in severity, frequency, and onset time in all PD patients. We assessed whether there is a negative effect on cognition of clinical autonomic dysfunction in PD patients.

Methods: This prospective study includes 37 PD patients with autonomic failure. From each patient, a questionnaire (SCOPA-AUT) including symptoms associated with clinical autonomic dysfunction such as constipation, urinary incontinence, orthostatic hypotension, and hyperhydrosis was obtained and the patient’s clinical condition was rated on the Hoehn and Yahr (H-Y) scale in the ON-medication state. The patients’ cognitive function was assessed by the Mini-Mental State Examination (MMSE), Blessed score, Frontal Assessment Battery (FAB), and Digid Span Test (DST) (forward, reverse). Cognitive test scores were compared with SCOPA-OUT scores.

Results: Mean age was 66,5±11.2 years. There was no correlation between cognitive test scores and SCOPA -OUT scores (p>0.05). However, H-Y scores were negatively correlated with the DSTf, DSTr, FAB, and MMSE scores (p50.005, r:-0.451; p50.025, r: -0.367; p50.040, r: -0.340; p50.044, r5-0.333, respectively).

Conclusions: According to our results, clinical autonomic dysfunction did not seem to ha ve an effect on cognition. In addition, severity of cognitive dysfunction showed a strong negative correlation with the stage of disease.

Keywords

Blessed score,Clinical autonomic dysfunction,Cognitive test,Parkinson’s disease

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Dursun Aygun This is me
Türkiye

Cetin Kursad Akpinar
Türkiye

Serpil Yon This is me
Türkiye

Musa Kazım Onar This is me
Türkiye

Publication Date

September 20, 2017

Submission Date

September 20, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 44 Number: 3

DOI

https://doi.org/10.5798/dicletip.338976

IZ

https://izlik.org/JA44FT69NA

Cite

RIS / Bibtex

APA

Aygun, D., Akpinar, C. K., Yon, S., & Onar, M. K. (2017). Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal, 44(3), 225-231. https://doi.org/10.5798/dicletip.338976

AMA

1.Aygun D, Akpinar CK, Yon S, Onar MK. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal. 2017;44(3):225-231. doi:10.5798/dicletip.338976

Chicago

Aygun, Dursun, Cetin Kursad Akpinar, Serpil Yon, and Musa Kazım Onar. 2017. “Effect of Clinical Autonomic Dysfunction on Cognitive Functions in Parkinson’s Disease”. Dicle Medical Journal 44 (3): 225-31. https://doi.org/10.5798/dicletip.338976.

EndNote

Aygun D, Akpinar CK, Yon S, Onar MK (September 1, 2017) Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal 44 3 225–231.

IEEE

[1]D. Aygun, C. K. Akpinar, S. Yon, and M. K. Onar, “Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease”, Dicle Medical Journal, vol. 44, no. 3, pp. 225–231, Sept. 2017, doi: 10.5798/dicletip.338976.

ISNAD

Aygun, Dursun - Akpinar, Cetin Kursad - Yon, Serpil - Onar, Musa Kazım. “Effect of Clinical Autonomic Dysfunction on Cognitive Functions in Parkinson’s Disease”. Dicle Medical Journal 44/3 (September 1, 2017): 225-231. https://doi.org/10.5798/dicletip.338976.

JAMA

1.Aygun D, Akpinar CK, Yon S, Onar MK. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal. 2017;44:225–231.

MLA

Aygun, Dursun, et al. “Effect of Clinical Autonomic Dysfunction on Cognitive Functions in Parkinson’s Disease”. Dicle Medical Journal, vol. 44, no. 3, Sept. 2017, pp. 225-31, doi:10.5798/dicletip.338976.

Vancouver

1.Dursun Aygun, Cetin Kursad Akpinar, Serpil Yon, Musa Kazım Onar. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal. 2017 Sep. 1;44(3):225-31. doi:10.5798/dicletip.338976

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

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