Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Dursun Aygun; Cetin Kursad Akpinar; Serpil Yon; Musa Kazım Onar

doi:10.5798/dicletip.338976

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Öz

Objective: Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. PD also involves nonmotor manifestations such as autonomic failure, cognitive disorders, and sleep disorders. These clinical characteristics are not identical in severity, frequency, and onset time in all PD patients. We assessed whether there is a negative effect on cognition of clinical autonomic dysfunction in PD patients.

Methods: This prospective study includes 37 PD patients with autonomic failure. From each patient, a questionnaire (SCOPA-AUT) including symptoms associated with clinical autonomic dysfunction such as constipation, urinary incontinence, orthostatic hypotension, and hyperhydrosis was obtained and the patient’s clinical condition was rated on the Hoehn and Yahr (H-Y) scale in the ON-medication state. The patients’ cognitive function was assessed by the Mini-Mental State Examination (MMSE), Blessed score, Frontal Assessment Battery (FAB), and Digid Span Test (DST) (forward, reverse). Cognitive test scores were compared with SCOPA-OUT scores.

Results: Mean age was 66,5±11.2 years. There was no correlation between cognitive test scores and SCOPA -OUT scores (p>0.05). However, H-Y scores were negatively correlated with the DSTf, DSTr, FAB, and MMSE scores (p50.005, r:-0.451; p50.025, r: -0.367; p50.040, r: -0.340; p50.044, r5-0.333, respectively).

Conclusions: According to our results, clinical autonomic dysfunction did not seem to ha ve an effect on cognition. In addition, severity of cognitive dysfunction showed a strong negative correlation with the stage of disease.

Anahtar Kelimeler

Blessed score,Clinical autonomic dysfunction,Cognitive test,Parkinson’s disease

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

Dursun Aygun Bu kişi benim
Türkiye

Cetin Kursad Akpinar
Türkiye

Serpil Yon Bu kişi benim
Türkiye

Musa Kazım Onar Bu kişi benim
Türkiye

Yayımlanma Tarihi

20 Eylül 2017

Gönderilme Tarihi

20 Eylül 2017

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2017 Cilt: 44 Sayı: 3

DOI

https://doi.org/10.5798/dicletip.338976

IZ

https://izlik.org/JA44FT69NA

Kaynak Göster

RIS / Bibtex

APA

Aygun, D., Akpinar, C. K., Yon, S., & Onar, M. K. (2017). Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal, 44(3), 225-231. https://doi.org/10.5798/dicletip.338976

AMA

1.Aygun D, Akpinar CK, Yon S, Onar MK. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. diclemedj. 2017;44(3):225-231. doi:10.5798/dicletip.338976

Chicago

Aygun, Dursun, Cetin Kursad Akpinar, Serpil Yon, ve Musa Kazım Onar. 2017. “Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease”. Dicle Medical Journal 44 (3): 225-31. https://doi.org/10.5798/dicletip.338976.

EndNote

Aygun D, Akpinar CK, Yon S, Onar MK (01 Eylül 2017) Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. Dicle Medical Journal 44 3 225–231.

IEEE

[1]D. Aygun, C. K. Akpinar, S. Yon, ve M. K. Onar, “Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease”, diclemedj, c. 44, sy 3, ss. 225–231, Eyl. 2017, doi: 10.5798/dicletip.338976.

ISNAD

Aygun, Dursun - Akpinar, Cetin Kursad - Yon, Serpil - Onar, Musa Kazım. “Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease”. Dicle Medical Journal 44/3 (01 Eylül 2017): 225-231. https://doi.org/10.5798/dicletip.338976.

JAMA

1.Aygun D, Akpinar CK, Yon S, Onar MK. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. diclemedj. 2017;44:225–231.

MLA

Aygun, Dursun, vd. “Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease”. Dicle Medical Journal, c. 44, sy 3, Eylül 2017, ss. 225-31, doi:10.5798/dicletip.338976.

Vancouver

1.Dursun Aygun, Cetin Kursad Akpinar, Serpil Yon, Musa Kazım Onar. Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease. diclemedj. 01 Eylül 2017;44(3):225-31. doi:10.5798/dicletip.338976

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

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