Eksozomlar ve Kanserdeki Rolleri

Süreyya Bozkurt

doi:10.5798/dicletip.424986

Eksozomlar ve Kanserdeki Rolleri

Abstract

Eksozomlar, vücutta bulunan hücrelerin neredeyse tamamı tarafından salgılanan, 40-100 nanometre (nm) çapında ve çift fosfolipid tabaka ile çevrili ekstrasellüler veziküllerdir. İçlerinde proteinler, lipitler, çok çeşitli RNA molekülleri ve DNA fragmenleri gibi birçok biyomolekül taşırlar. Bu biyomoleküller vasıtasıyla, alıcı hücrelerde gen ifadelerini düzenleyerek, immün regülasyon, hücre farklılaşması, hücreler arası haberleşme, hücre göçü gibi birçok biyolojik fonksiyonda rol alırlar. Tümör kökenli eksozomlar ise içlerinde taşıdıkları biyomoleküller vasıtasıyla kanserin gelişimi ve yayılımına yardım etmek için lokal ve sistemik çevreyi düzenlerler. Eksozom içeriklerinin kanserin tanısında ve hastalık seyrinin izlenmesinde biyobelirteç olarak kullanım potansiyellerini araştıran çalışmalar hızla artmaktadır. Ayrıca son yıllarda kanser tedavisinde eksozomların hedeflendiği ya da kullanıldığı yaklaşımlar da bulunmaktadır. Bu derlemenin amacı eksozomların yapısının, kanser gelişimindeki ve metastazdaki rollerinin ve kanser tedavisindeki kullanım potansiyellerinin ortaya konmasıdır.

Keywords

Eksozomlar,kanser,tümör metastazı

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Süreyya Bozkurt ^*
0000-0002-1765-9894
Türkiye

Publication Date

June 15, 2018

Submission Date

May 18, 2018

Acceptance Date

April 2, 2018

Published in Issue

Year 2018 Volume: 45 Number: 2

DOI

https://doi.org/10.5798/dicletip.424986

IZ

https://izlik.org/JA63HT99TK

Cite

RIS / Bibtex

APA

Bozkurt, S. (2018). Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal, 45(2), 209-217. https://doi.org/10.5798/dicletip.424986

AMA

1.Bozkurt S. Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal. 2018;45(2):209-217. doi:10.5798/dicletip.424986

Chicago

Bozkurt, Süreyya. 2018. “Eksozomlar Ve Kanserdeki Rolleri”. Dicle Medical Journal 45 (2): 209-17. https://doi.org/10.5798/dicletip.424986.

EndNote

Bozkurt S (June 1, 2018) Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal 45 2 209–217.

IEEE

[1]S. Bozkurt, “Eksozomlar ve Kanserdeki Rolleri”, Dicle Medical Journal, vol. 45, no. 2, pp. 209–217, June 2018, doi: 10.5798/dicletip.424986.

ISNAD

Bozkurt, Süreyya. “Eksozomlar Ve Kanserdeki Rolleri”. Dicle Medical Journal 45/2 (June 1, 2018): 209-217. https://doi.org/10.5798/dicletip.424986.

JAMA

1.Bozkurt S. Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal. 2018;45:209–217.

MLA

Bozkurt, Süreyya. “Eksozomlar Ve Kanserdeki Rolleri”. Dicle Medical Journal, vol. 45, no. 2, June 2018, pp. 209-17, doi:10.5798/dicletip.424986.

Vancouver

1.Süreyya Bozkurt. Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal. 2018 Jun. 1;45(2):209-17. doi:10.5798/dicletip.424986

Cited By

Eksozomlar: Kompozisyonları, Biyolojik Fonksiyonları ve Biyoaktif Bileşiklerin Taşınmasındaki Potansiyelleri

Akademik Gıda

https://doi.org/10.24323/akademik-gida.850939