Eksozomlar ve Kanserdeki Rolleri

Süreyya Bozkurt

doi:10.5798/dicletip.424986

Eksozomlar ve Kanserdeki Rolleri

Öz

Eksozomlar, vücutta bulunan hücrelerin neredeyse tamamı tarafından salgılanan, 40-100 nanometre (nm) çapında ve çift fosfolipid tabaka ile çevrili ekstrasellüler veziküllerdir. İçlerinde proteinler, lipitler, çok çeşitli RNA molekülleri ve DNA fragmenleri gibi birçok biyomolekül taşırlar. Bu biyomoleküller vasıtasıyla, alıcı hücrelerde gen ifadelerini düzenleyerek, immün regülasyon, hücre farklılaşması, hücreler arası haberleşme, hücre göçü gibi birçok biyolojik fonksiyonda rol alırlar. Tümör kökenli eksozomlar ise içlerinde taşıdıkları biyomoleküller vasıtasıyla kanserin gelişimi ve yayılımına yardım etmek için lokal ve sistemik çevreyi düzenlerler. Eksozom içeriklerinin kanserin tanısında ve hastalık seyrinin izlenmesinde biyobelirteç olarak kullanım potansiyellerini araştıran çalışmalar hızla artmaktadır. Ayrıca son yıllarda kanser tedavisinde eksozomların hedeflendiği ya da kullanıldığı yaklaşımlar da bulunmaktadır. Bu derlemenin amacı eksozomların yapısının, kanser gelişimindeki ve metastazdaki rollerinin ve kanser tedavisindeki kullanım potansiyellerinin ortaya konmasıdır.

Anahtar Kelimeler

Eksozomlar,kanser,tümör metastazı

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Süreyya Bozkurt ^*
0000-0002-1765-9894
Türkiye

Yayımlanma Tarihi

15 Haziran 2018

Gönderilme Tarihi

18 Mayıs 2018

Kabul Tarihi

2 Nisan 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 45 Sayı: 2

DOI

https://doi.org/10.5798/dicletip.424986

IZ

https://izlik.org/JA63HT99TK

Kaynak Göster

RIS / Bibtex

APA

Bozkurt, S. (2018). Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal, 45(2), 209-217. https://doi.org/10.5798/dicletip.424986

AMA

1.Bozkurt S. Eksozomlar ve Kanserdeki Rolleri. diclemedj. 2018;45(2):209-217. doi:10.5798/dicletip.424986

Chicago

Bozkurt, Süreyya. 2018. “Eksozomlar ve Kanserdeki Rolleri”. Dicle Medical Journal 45 (2): 209-17. https://doi.org/10.5798/dicletip.424986.

EndNote

Bozkurt S (01 Haziran 2018) Eksozomlar ve Kanserdeki Rolleri. Dicle Medical Journal 45 2 209–217.

IEEE

[1]S. Bozkurt, “Eksozomlar ve Kanserdeki Rolleri”, diclemedj, c. 45, sy 2, ss. 209–217, Haz. 2018, doi: 10.5798/dicletip.424986.

ISNAD

Bozkurt, Süreyya. “Eksozomlar ve Kanserdeki Rolleri”. Dicle Medical Journal 45/2 (01 Haziran 2018): 209-217. https://doi.org/10.5798/dicletip.424986.

JAMA

1.Bozkurt S. Eksozomlar ve Kanserdeki Rolleri. diclemedj. 2018;45:209–217.

MLA

Bozkurt, Süreyya. “Eksozomlar ve Kanserdeki Rolleri”. Dicle Medical Journal, c. 45, sy 2, Haziran 2018, ss. 209-17, doi:10.5798/dicletip.424986.

Vancouver

1.Süreyya Bozkurt. Eksozomlar ve Kanserdeki Rolleri. diclemedj. 01 Haziran 2018;45(2):209-17. doi:10.5798/dicletip.424986

Cited By

Eksozomlar: Kompozisyonları, Biyolojik Fonksiyonları ve Biyoaktif Bileşiklerin Taşınmasındaki Potansiyelleri

Akademik Gıda

https://doi.org/10.24323/akademik-gida.850939