Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Promil Jain; Monika Gupta; Shivani Dua; Nisha Marwah; Meenu Gill; Rajeev Sen

doi:10.5798/dicletip.539869

Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Abstract

Objective: To find out the prevalence of thalassemias and various other hemoglobinopathies in state of Haryana and to assess the role of High performance liquid chromatography (HPLC) for accurate and quick diagnosis of various hemoglobin disorders.

Methods: This study was conducted in Pt. B. D. Sharma, PGIMS, Rohtak from July 2010 to October 2016 for hemoglobin variant screening by HPLC of total of 4275 patients, selected through multistage random sampling technique.

Results: Among 4275 total cases surveyed, normal hemoglobin pattern was observed in 3862 (90.3%) and abnormal hemoglobin fractions on HPLC were detected in 413 (9.7%). Βeta (β) thalassemia trait was predominant abnormality found in a total of 318 cases (7.4%). There were 19 cases of β-thalassemia major and 24 of β-thalassemia intermedia. Other abnormal patterns found were HbE (trait in 11 and HbE disease in 6 cases), Hb S (2 cases each of sickle cell disease and sickle cell trait), 2 cases of high Hb F (1 case each of heterozygous and homozygous HPFH), 11 cases of Hb D Punjab along with 2 cases of Hb D Iran, 1 case of Hb C and 2 cases each of double heterozygotes for Hb E/ β-thalassemia and Hb S/ β-thalassemia.

Conclusion: There is high prevalence of hemoglobinopathies in this region and HPLC forms a rapid and accurate tool in early detection and management of various hemoglobinopathies.

Keywords

Hemoglobinopathies,Thalassemia

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Promil Jain ^*
0000-0002-6390-7465

Monika Gupta This is me
0000-0003-3438-2943

Shivani Dua This is me
0000-0002-4701-5934

Nisha Marwah This is me
0000-0002-7017-9785

Meenu Gill This is me
0000-0001-5913-8918

Rajeev Sen This is me
0000-0001-7957-5613

Publication Date

June 11, 2019

Submission Date

September 8, 2017

Acceptance Date

June 7, 2018

Published in Issue

Year 2019 Volume: 46 Number: 2

DOI

https://doi.org/10.5798/dicletip.539869

IZ

https://izlik.org/JA69MD56DM

Cite

RIS / Bibtex

APA

Jain, P., Gupta, M., Dua, S., Marwah, N., Gill, M., & Sen, R. (2019). Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal, 46(2), 269-276. https://doi.org/10.5798/dicletip.539869

AMA

1.Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal. 2019;46(2):269-276. doi:10.5798/dicletip.539869

Chicago

Jain, Promil, Monika Gupta, Shivani Dua, Nisha Marwah, Meenu Gill, and Rajeev Sen. 2019. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal 46 (2): 269-76. https://doi.org/10.5798/dicletip.539869.

EndNote

Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R (June 1, 2019) Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal 46 2 269–276.

IEEE

[1]P. Jain, M. Gupta, S. Dua, N. Marwah, M. Gill, and R. Sen, “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”, Dicle Medical Journal, vol. 46, no. 2, pp. 269–276, June 2019, doi: 10.5798/dicletip.539869.

ISNAD

Jain, Promil - Gupta, Monika - Dua, Shivani - Marwah, Nisha - Gill, Meenu - Sen, Rajeev. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal 46/2 (June 1, 2019): 269-276. https://doi.org/10.5798/dicletip.539869.

JAMA

1.Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal. 2019;46:269–276.

MLA

Jain, Promil, et al. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal, vol. 46, no. 2, June 2019, pp. 269-76, doi:10.5798/dicletip.539869.

Vancouver

1.Promil Jain, Monika Gupta, Shivani Dua, Nisha Marwah, Meenu Gill, Rajeev Sen. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal. 2019 Jun. 1;46(2):269-76. doi:10.5798/dicletip.539869