Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Promil Jain; Monika Gupta; Shivani Dua; Nisha Marwah; Meenu Gill; Rajeev Sen

doi:10.5798/dicletip.539869

Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Öz

Objective: To find out the prevalence of thalassemias and various other hemoglobinopathies in state of Haryana and to assess the role of High performance liquid chromatography (HPLC) for accurate and quick diagnosis of various hemoglobin disorders.

Methods: This study was conducted in Pt. B. D. Sharma, PGIMS, Rohtak from July 2010 to October 2016 for hemoglobin variant screening by HPLC of total of 4275 patients, selected through multistage random sampling technique.

Results: Among 4275 total cases surveyed, normal hemoglobin pattern was observed in 3862 (90.3%) and abnormal hemoglobin fractions on HPLC were detected in 413 (9.7%). Βeta (β) thalassemia trait was predominant abnormality found in a total of 318 cases (7.4%). There were 19 cases of β-thalassemia major and 24 of β-thalassemia intermedia. Other abnormal patterns found were HbE (trait in 11 and HbE disease in 6 cases), Hb S (2 cases each of sickle cell disease and sickle cell trait), 2 cases of high Hb F (1 case each of heterozygous and homozygous HPFH), 11 cases of Hb D Punjab along with 2 cases of Hb D Iran, 1 case of Hb C and 2 cases each of double heterozygotes for Hb E/ β-thalassemia and Hb S/ β-thalassemia.

Conclusion: There is high prevalence of hemoglobinopathies in this region and HPLC forms a rapid and accurate tool in early detection and management of various hemoglobinopathies.

Anahtar Kelimeler

Hemoglobinopathies,Thalassemia

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Promil Jain ^*
0000-0002-6390-7465

Monika Gupta Bu kişi benim
0000-0003-3438-2943

Shivani Dua Bu kişi benim
0000-0002-4701-5934

Nisha Marwah Bu kişi benim
0000-0002-7017-9785

Meenu Gill Bu kişi benim
0000-0001-5913-8918

Rajeev Sen Bu kişi benim
0000-0001-7957-5613

Yayımlanma Tarihi

11 Haziran 2019

Gönderilme Tarihi

8 Eylül 2017

Kabul Tarihi

7 Haziran 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 46 Sayı: 2

DOI

https://doi.org/10.5798/dicletip.539869

IZ

https://izlik.org/JA69MD56DM

Kaynak Göster

RIS / Bibtex

APA

Jain, P., Gupta, M., Dua, S., Marwah, N., Gill, M., & Sen, R. (2019). Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal, 46(2), 269-276. https://doi.org/10.5798/dicletip.539869

AMA

1.Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. diclemedj. 2019;46(2):269-276. doi:10.5798/dicletip.539869

Chicago

Jain, Promil, Monika Gupta, Shivani Dua, Nisha Marwah, Meenu Gill, ve Rajeev Sen. 2019. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal 46 (2): 269-76. https://doi.org/10.5798/dicletip.539869.

EndNote

Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R (01 Haziran 2019) Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. Dicle Medical Journal 46 2 269–276.

IEEE

[1]P. Jain, M. Gupta, S. Dua, N. Marwah, M. Gill, ve R. Sen, “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”, diclemedj, c. 46, sy 2, ss. 269–276, Haz. 2019, doi: 10.5798/dicletip.539869.

ISNAD

Jain, Promil - Gupta, Monika - Dua, Shivani - Marwah, Nisha - Gill, Meenu - Sen, Rajeev. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal 46/2 (01 Haziran 2019): 269-276. https://doi.org/10.5798/dicletip.539869.

JAMA

1.Jain P, Gupta M, Dua S, Marwah N, Gill M, Sen R. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. diclemedj. 2019;46:269–276.

MLA

Jain, Promil, vd. “Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre”. Dicle Medical Journal, c. 46, sy 2, Haziran 2019, ss. 269-76, doi:10.5798/dicletip.539869.

Vancouver

1.Promil Jain, Monika Gupta, Shivani Dua, Nisha Marwah, Meenu Gill, Rajeev Sen. Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre. diclemedj. 01 Haziran 2019;46(2):269-76. doi:10.5798/dicletip.539869