Primer Plazma Hücreli Lösemi: Olgu Sunumu

Sinan Demircioğlu; Ali Doğan; Murat Altınbaşak; Cengiz Demir

doi:10.5798/dicletip.575025

Primer Plazma Hücreli Lösemi: Olgu Sunumu

Abstract

Plazma hücreli lösemi (PHL), plazma hücreli diskrazilerin nadir görülen bir formudur. Primer ve sekonder PHL olmak üzere iki formu vardır. Prognozu oldukça kötüdür. Morfolojik olarak matür plazma hücrelerine benzememesi sebebiyle tanıda karışıklıklar olabilmektedir. Tedavide bortezomib bazlı rejimler ve otolog kök hücre nakli önerilmektedir.

Keywords

Morfoloji,multiple myelom,plazma hücreli lösemi

References

1. Sant M, Allemani C, Tereanu C, et all. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood 2010; 116: 3724-34.2. Noel P, Kyle RA. Plasma cell leukemia: an evaluation of response to therapy. The American journal of medicine 1987; 83: 1062-8.
3. Tiedemann RE, Gonzalez-Paz N, Kyle RA, et all. Genetic aberrations and survival in plasma cell leukemia. Leukemia 2008; 22: 1044-52.
4. Fernandez de Larrea C, Kyle RA, Durie BG, et all. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia 2013; 27: 780-91.
5. Garcia-Sanz R, Orfao A, Gonzalez M, et all. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 1999; 93: 1032-7.
6. Greipp PR, Raymond NM, Kyle RA, O'Fallon WM. Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood 1985; 65: 305-10.
7. Kyle RA, Gertz MA, Witzig TE, et all. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003; 78: 21-33.
8. Blade J, Kyle RA. Multiple myeloma in young patients: clinical presentation and treatment approach. Leuk Lymphoma 1998; 30: 493-501.
9. Gonsalves WI, Rajkumar SV, Go RS, et all. Trends in survival of patients with primary plasma cell leukemia: a population-based analysis. Blood 2014; 124: 907-12.

10. Musto P. Progress in the Treatment of Primary Plasma Cell Leukemia. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2016; 34: 2082-4.
11. Musto P, Simeon V, Martorelli MC, et all. Lenalidomide and low-dose dexamethasone for newly diagnosed primary plasma cell leukemia. Leukemia 2014; 28: 222-5.
12. Royer B, Minvielle S, Diouf M, et all. Bortezomib, Doxorubicin, Cyclophosphamide, Dexamethasone Induction Followed by Stem Cell Transplantation for Primary Plasma Cell Leukemia: A Prospective Phase II Study of the Intergroupe Francophone du Myelome. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016; 34: 2125-32.
13. Jung SH, Lee JJ, Kim K, et all. The role of frontline autologous stem cell transplantation for primary plasma cell leukemia: a retrospective multicenter study (KMM160). Oncotarget 2017; 8: 79517-26.
14. Granell M, Calvo X, Garcia-Guinon A, et all. Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition. Haematologica 2017; 102: 1099-104.
15. D'Arena G, Valentini CG, Pietrantuono G, et all. Frontline chemotherapy with bortezomib-containing combinations improves response rate and survival in primary plasma cell leukemia: a retrospective study from GIMEMA Multiple Myeloma Working Party. Ann Oncol 2012; 23: 1499-502.
16. Katodritou E, Terpos E, Kelaidi C, et all. Treatment with bortezomib-based regimens improves overall response and predicts for survival in patients with primary or secondary plasma cell leukemia: Analysis of the Greek myeloma study group. American journal of hematology 2014; 89: 145-50.
17. Lebovic D, Zhang L, Alsina M, et all. Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a single-institution experience. Clinical lymphoma, myeloma & leukemia 2011; 11: 507-11.
18. van de Donk NW, Lokhorst HM, Anderson KC, Richardson PG. How I treat plasma cell leukemia. Blood 2012; 120: 2376-89.
19. Mahindra A, Kalaycio ME, Vela-Ojeda J, et all. Hematopoietic cell transplantation for primary plasma cell leukemia: results from the Center for International Blood and Marrow Transplant Research. Leukemia 2012; 26: 1091-7.
20. Nishihori T, Abu Kar SM, Baz R, et all. Therapeutic advances in the treatment of primary plasma cell leukemia: a focus on hematopoietic cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013; 19: 1144-51.
21. Chim CS, Kumar SK, Orlowski RZ, et all. Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond. Leukemia 2018; 32: 252-62.

Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Case Report

Authors

Sinan Demircioğlu ^* This is me
0000-0003-1277-5105

Ali Doğan This is me
0000-0003-0207-3505

Murat Altınbaşak This is me
0000-0001-9058-1424

Cengiz Demir This is me
0000-0001-9856-184X

Publication Date

June 11, 2019

Submission Date

February 26, 2019

Acceptance Date

May 10, 2019

Published in Issue

Year 2019 Volume: 46 Number: 2

DOI

https://doi.org/10.5798/dicletip.575025

IZ

https://izlik.org/JA94EU24HT

Cite

RIS / Bibtex

APA

Demircioğlu, S., Doğan, A., Altınbaşak, M., & Demir, C. (2019). Primer Plazma Hücreli Lösemi: Olgu Sunumu. Dicle Medical Journal, 46(2), 393-396. https://doi.org/10.5798/dicletip.575025

AMA

1.Demircioğlu S, Doğan A, Altınbaşak M, Demir C. Primer Plazma Hücreli Lösemi: Olgu Sunumu. Dicle Medical Journal. 2019;46(2):393-396. doi:10.5798/dicletip.575025

Chicago

Demircioğlu, Sinan, Ali Doğan, Murat Altınbaşak, and Cengiz Demir. 2019. “Primer Plazma Hücreli Lösemi: Olgu Sunumu”. Dicle Medical Journal 46 (2): 393-96. https://doi.org/10.5798/dicletip.575025.

EndNote

Demircioğlu S, Doğan A, Altınbaşak M, Demir C (June 1, 2019) Primer Plazma Hücreli Lösemi: Olgu Sunumu. Dicle Medical Journal 46 2 393–396.

IEEE

[1]S. Demircioğlu, A. Doğan, M. Altınbaşak, and C. Demir, “Primer Plazma Hücreli Lösemi: Olgu Sunumu”, Dicle Medical Journal, vol. 46, no. 2, pp. 393–396, June 2019, doi: 10.5798/dicletip.575025.

ISNAD

Demircioğlu, Sinan - Doğan, Ali - Altınbaşak, Murat - Demir, Cengiz. “Primer Plazma Hücreli Lösemi: Olgu Sunumu”. Dicle Medical Journal 46/2 (June 1, 2019): 393-396. https://doi.org/10.5798/dicletip.575025.

JAMA

1.Demircioğlu S, Doğan A, Altınbaşak M, Demir C. Primer Plazma Hücreli Lösemi: Olgu Sunumu. Dicle Medical Journal. 2019;46:393–396.

MLA

Demircioğlu, Sinan, et al. “Primer Plazma Hücreli Lösemi: Olgu Sunumu”. Dicle Medical Journal, vol. 46, no. 2, June 2019, pp. 393-6, doi:10.5798/dicletip.575025.

Vancouver

1.Sinan Demircioğlu, Ali Doğan, Murat Altınbaşak, Cengiz Demir. Primer Plazma Hücreli Lösemi: Olgu Sunumu. Dicle Medical Journal. 2019 Jun. 1;46(2):393-6. doi:10.5798/dicletip.575025