Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Erkan Dalbaşı; Ercan Gedik; Abidin Tüzün; Basra Deniz Obay

doi:10.5798/dicletip.755706

Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Abstract

Objective: Generalized peritonitis is fairly common with very high mortality of delayed diagnosis and treatment of infectious condition. In this study, we aimed to determine the effectiveness of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and C-reactive protein (CRP) levels in peritonitis severity. Methods: This study was planned prospective and randomized. Study consisted of three groups. Each group had 50 patients. Group 1, patients with generalize peritonitis ; Group 2,patients with non-abdominal inflammatory disease; Group 3, healthy individuals as a control group. The venous blood samples from patients in group 1 and 2 were collected to determine MDA, SOD, CAT and CRP levels at the operation day. The same procedures repeated postoperative first and third day. Blood samples were collected once from group 3.One-way Anova test was used to compare average of intergroup parametric variables. Repeated Anova test was used to compare intragroup parameters. Results: Demographic features and cause of laparatomy of all groups were evaluated. MDA values of group 1 in days 0, 1st and 3rd compared with group 2 and group 3 the MDA values of group 1 were higher than group 2 and 3 (p<0,0001). CAT values of group 1 in days 0, 1st and 3rd were lower than group 2 and group 3 (p<0,0001). SOD values of group 1 and 2 in day 0 were lower than group 3 (p<0,0001). CRP values of group 1 in days 0,1st and 3rd were higher than group 2 (p<0,0001). Conclusions: It was concluded that SOD, CAT, MDA and CRP are useful parameters for the diagnosis and monitoring of generalized peritonitis severity.

Keywords

Generalized peritonitis,superoxide dismutase

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Erkan Dalbaşı This is me
Türkiye

Ercan Gedik This is me
Türkiye

Abidin Tüzün This is me
Türkiye

Basra Deniz Obay This is me
Türkiye

Publication Date

June 17, 2020

Submission Date

December 24, 2019

Acceptance Date

June 11, 2020

Published in Issue

Year 2020 Volume: 47 Number: 2

DOI

https://doi.org/10.5798/dicletip.755706

IZ

https://izlik.org/JA98CP32CL

Cite

RIS / Bibtex

APA

Dalbaşı, E., Gedik, E., Tüzün, A., & Obay, B. D. (2020). Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal, 47(2), 293-303. https://doi.org/10.5798/dicletip.755706

AMA

1.Dalbaşı E, Gedik E, Tüzün A, Obay BD. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal. 2020;47(2):293-303. doi:10.5798/dicletip.755706

Chicago

Dalbaşı, Erkan, Ercan Gedik, Abidin Tüzün, and Basra Deniz Obay. 2020. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels With Peritonitis Severity in Patients With Generalized Peritonitis”. Dicle Medical Journal 47 (2): 293-303. https://doi.org/10.5798/dicletip.755706.

EndNote

Dalbaşı E, Gedik E, Tüzün A, Obay BD (June 1, 2020) Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal 47 2 293–303.

IEEE

[1]E. Dalbaşı, E. Gedik, A. Tüzün, and B. D. Obay, “Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis”, Dicle Medical Journal, vol. 47, no. 2, pp. 293–303, June 2020, doi: 10.5798/dicletip.755706.

ISNAD

Dalbaşı, Erkan - Gedik, Ercan - Tüzün, Abidin - Obay, Basra Deniz. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels With Peritonitis Severity in Patients With Generalized Peritonitis”. Dicle Medical Journal 47/2 (June 1, 2020): 293-303. https://doi.org/10.5798/dicletip.755706.

JAMA

1.Dalbaşı E, Gedik E, Tüzün A, Obay BD. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal. 2020;47:293–303.

MLA

Dalbaşı, Erkan, et al. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels With Peritonitis Severity in Patients With Generalized Peritonitis”. Dicle Medical Journal, vol. 47, no. 2, June 2020, pp. 293-0, doi:10.5798/dicletip.755706.

Vancouver

1.Erkan Dalbaşı, Ercan Gedik, Abidin Tüzün, Basra Deniz Obay. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal. 2020 Jun. 1;47(2):293-30. doi:10.5798/dicletip.755706

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