Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Erkan Dalbaşı; Ercan Gedik; Abidin Tüzün; Basra Deniz Obay

doi:10.5798/dicletip.755706

Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Öz

Objective: Generalized peritonitis is fairly common with very high mortality of delayed diagnosis and treatment of infectious condition. In this study, we aimed to determine the effectiveness of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and C-reactive protein (CRP) levels in peritonitis severity. Methods: This study was planned prospective and randomized. Study consisted of three groups. Each group had 50 patients. Group 1, patients with generalize peritonitis ; Group 2,patients with non-abdominal inflammatory disease; Group 3, healthy individuals as a control group. The venous blood samples from patients in group 1 and 2 were collected to determine MDA, SOD, CAT and CRP levels at the operation day. The same procedures repeated postoperative first and third day. Blood samples were collected once from group 3.One-way Anova test was used to compare average of intergroup parametric variables. Repeated Anova test was used to compare intragroup parameters. Results: Demographic features and cause of laparatomy of all groups were evaluated. MDA values of group 1 in days 0, 1st and 3rd compared with group 2 and group 3 the MDA values of group 1 were higher than group 2 and 3 (p<0,0001). CAT values of group 1 in days 0, 1st and 3rd were lower than group 2 and group 3 (p<0,0001). SOD values of group 1 and 2 in day 0 were lower than group 3 (p<0,0001). CRP values of group 1 in days 0,1st and 3rd were higher than group 2 (p<0,0001). Conclusions: It was concluded that SOD, CAT, MDA and CRP are useful parameters for the diagnosis and monitoring of generalized peritonitis severity.

Anahtar Kelimeler

Generalized peritonitis,superoxide dismutase

Kaynakça

1. Schwarts S (çeviri:Şen D.) İntraabdominal Enfeksiyonlar. In: Solomkin JS, Wittman DW, West MA, Barie PS (eds) (çeviri editörü: Geçim E). Cerrahinin İlkeleri (7thEd.) İstanbul.1999.p.1537-76.
2. Ertekin C, Karın içi enfeksiyonlar. In: Kalaycı G (eds), Genel cerrahi-1, İstanbul.2002.p. 217-57
3. Witmann DH, Teichmann W, Müler M. Development and validation of peritonitis indices Altona. Langenbecks Arch Chir.1987.p. 834-5.
4. Yagi K. Lipid Peroxidase and Human Diseases. Chemistry And Physics of Lipids. 1987; 45(2-4): p.337-51.
5. Mercan U.Toksikolojide Serbest Radikallerin Önemi. YYU Vet. Fak. Derg. 2004.15.p.91-6.
6. Şimşek F. Serbest Oksijen Radikalleri, Antioksidanlar ve Lipid Peroksidayonu. Türkiye Klinikleri J Pediatri. 1999; 8.p.42-7.
7. Yücel T, Gönüllü D, Güçlü S. et al. Normobarik Oksijenin Deneysel Peritonitin Tedavisindeki Yeri ve Tedavinin İzlenmesinde Rektal Ateş, Lökosit, CRP ve Prokalsitoninin Etkinliği. Ulusal Travma Acil Cerrahi Derg.2008;14.p.14-20.
8. Ulubaş F.Ç.B, Eryılmaz T, Bilgin G. Sigara İçenlerde Lipid Peroksidayonu, Antioksidan Aktivite ve Solunum Fonksiyon Testler. Türkiye Klinikleri Tıp Bilimleri Dergisi 2002; 22.p.292-96.

9. T Sisinta, B Wispriyono, H Kusnoputranto. Cigarette Smoke Exposure and Oxidative Stress in Junior High School Children. Journal of International Dental & Medical Research. 2019; 12. P.372-6.
10. Yarıktaş M, Döner F, Doğru H, ve ark. Baş-Boyun Malign Tümörlerinde MDA düzeyleri ve antioksidan enzim aktiviteleri. Süleyman Demirel Üniversitesi (SDÜ) Tıp Fak. Derg.2003; 10.p.65-7.
11. Sohail H, Ashafaq M. Oxidative Stress and Anti-oxidants in Pre and Post-operative Cases of Breast Carcinoma. Turk J Pharm Sci 2018; 15.p.354-59.
12. Menteşe A, Erkut N, Demir S, et al. Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia. Turk J Haematol. 2017; 34.p.307–13.
13. Gökalp O, Karakoyun I, Kaleli S, Özer M.K, Gültekin F. Chlorpyrifos Ethyl’in Rat pankreası Üzerine Etkisi. S.D.Ü Tıp Fak. Derg.2005;12.p.19-22.
14. Rahmadani N.M.N, Rachmawati D.A, Elfiah U. The Difference of Plasma Malondialdehyde (MDA) Level in Farmers Using Chemical Pesticides and Farmers Using Organic Pesticides. Journal of Agromedicine and Medical Science.2018; 4.p.165-70.
15. Obay B,D. Deneysel Serebral İskemide Antioksidan Savunma Sistemi ve Serbest Radikal Temizleyicilerin Rolü, Doktora Tezi, Dicle Üniversitesi Tıp Fak. Fizyoloji ABD, 1999.
16. Uchiyama M, Mihara M. Determination of malondialdehyde precursor in tissue by thiobarbituric acit test avaleyt biochem,1978; 86.p.271-78.
17. Aebi H.Catalase in vitro. Methods in enzymology.1984; 86.p.271-78.
18. Wittman D.İntraabdominal İnfeksiyonlar. İn: Sayek İ.(eds).Temel Cerrahi 2 (2nd ed.) 1996. p.1408-33.
19. Shinde A, Ganu J, Naik P. Effect of Free Radicals & Antioxidants on Oxidative Stress Journal of Dental & Allied Sciences 2012; 1.p.63-6.
20. Smith R.P,Lipworth B.J. C-reactive Protein in Simple Community-Acquired Pneumonia. Chest J. 1995; 107.p.1028-31.
21. Guzel Ö, Gulcubuk A, Yildar E, et.al. Effects of antibiotic and intra-peritoneal ozone administration on proinflammatory cytokine formation, antioxidant levels and abdominal organ functions in the treatment of experimentally generated infectious peritonitis in rabbits. Veterinarni Medicina 64, 2019; 08.p.348–61.
22. Erginel B, Aydin F.A, Erginel T. et. al. Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis. Published Online: 19 Jan 2016 https://doi.org/10.1089/sur.2015.072.
23. Zhang J, Wu Q, Song S et.al. Effect of hydrogen-rich water on acute peritonitis of rat models. International Immunopharmacology 2014; 21. p. 94-101.
24. Chenorcid L, Cao D, Liu E, et al. Rat Model of Cecal Ligation and Puncture versus Colon Ascendens Stent Peritonitis: Comparative Study for Oxidative Stress. Advances in Infectious Diseases. 2017; 7.p. 80-92.
25. Corradi F, Brusasco C, Fernández J. et al. Effects of pentoxifylline on intestinal bacterial overgrowth, bacterial translocation and spontaneous bacterial peritonitis in cirrhotic rats with ascites. Digestive and Liver Disease J.of Gastroenterology and Hepatology. 2012; 44.p.239-44.
26. Kumar Y, Singh G, Davidson R.B. Free Radical and Antioxidant Levels in Patients with Secondary Peritonitis and Their Prognostic Signifiance. Dig Surg 2007; 24.p.331–7.
27. Fujimara N, Sumita S, Aimono M. et al. Effect of Free Radical Scavengers on Diaphragmatic Contractility in Septic Peritonitis. American Journal of Respiratory and Critical Care Medicine.2000; 162.p.2159-65.
28. Ayrık C, Karaaslan U, Dağ A, et al. Predictive Value of Leucocyte Count, Neutrophil Percent and C-Reactive Protein Concentration “Cut-Off Value” On The Diagnose Of Appendicitis. Ulus Travma Acil Cerrahi Derg. 2016; 22.p.76-83.
29. Moon S.J, Han S.H, Kim D.K, et al. Risk Factors for Adverse Outcomes After Peritonitis-Related Technique Failure. Peritoneal Dialysis International. 2008; 28.p.352-60.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Erkan Dalbaşı Bu kişi benim
Türkiye

Ercan Gedik Bu kişi benim
Türkiye

Abidin Tüzün Bu kişi benim
Türkiye

Basra Deniz Obay Bu kişi benim
Türkiye

Yayımlanma Tarihi

17 Haziran 2020

Gönderilme Tarihi

24 Aralık 2019

Kabul Tarihi

11 Haziran 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 47 Sayı: 2

DOI

https://doi.org/10.5798/dicletip.755706

IZ

https://izlik.org/JA98CP32CL

Kaynak Göster

RIS / Bibtex

APA

Dalbaşı, E., Gedik, E., Tüzün, A., & Obay, B. D. (2020). Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal, 47(2), 293-303. https://doi.org/10.5798/dicletip.755706

AMA

1.Dalbaşı E, Gedik E, Tüzün A, Obay BD. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. diclemedj. 2020;47(2):293-303. doi:10.5798/dicletip.755706

Chicago

Dalbaşı, Erkan, Ercan Gedik, Abidin Tüzün, ve Basra Deniz Obay. 2020. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis”. Dicle Medical Journal 47 (2): 293-303. https://doi.org/10.5798/dicletip.755706.

EndNote

Dalbaşı E, Gedik E, Tüzün A, Obay BD (01 Haziran 2020) Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. Dicle Medical Journal 47 2 293–303.

IEEE

[1]E. Dalbaşı, E. Gedik, A. Tüzün, ve B. D. Obay, “Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis”, diclemedj, c. 47, sy 2, ss. 293–303, Haz. 2020, doi: 10.5798/dicletip.755706.

ISNAD

Dalbaşı, Erkan - Gedik, Ercan - Tüzün, Abidin - Obay, Basra Deniz. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis”. Dicle Medical Journal 47/2 (01 Haziran 2020): 293-303. https://doi.org/10.5798/dicletip.755706.

JAMA

1.Dalbaşı E, Gedik E, Tüzün A, Obay BD. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. diclemedj. 2020;47:293–303.

MLA

Dalbaşı, Erkan, vd. “Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis”. Dicle Medical Journal, c. 47, sy 2, Haziran 2020, ss. 293-0, doi:10.5798/dicletip.755706.

Vancouver

1.Erkan Dalbaşı, Ercan Gedik, Abidin Tüzün, Basra Deniz Obay. Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis. diclemedj. 01 Haziran 2020;47(2):293-30. doi:10.5798/dicletip.755706

Cited By

Endogenous intoxication indicators in advanced peritonitis and their correction

Klinicheskaia khirurgiia

https://doi.org/10.26779/2522-1396.2021.1-2.39

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

International Journal of Clinical Practice

https://doi.org/10.1111/ijcp.14232

Oxidative modification of proteins and antioxidant status in blood of the rats with experimental acute generalized peritonitis against the background of streptozotocin-induced diabetes

Regulatory Mechanisms in Biosystems

https://doi.org/10.15421/022338