Research Article
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Pulmonary hamartoma: Retrospective analysis of 24 cases

Year 2019, Volume: 46 Issue: 1, 27 - 32, 03.03.2019
https://doi.org/10.5798/dicletip.534820

Abstract

Objective:
Lung hamartoma is the most frequently diagnosed benign lung tumor. The aim of
this study was to investigate the clinical, radiological and pathological data
of the patients with pulmonary hamartoma who underwent surgical treatment in
our clinic.



Methods: Hospital
records of 24 lung hamartoma patients given surgical treatment in our clinics
between January 2005 and December 2017 were investigated retrospectively. In
this study, these cases were evaluated with respect to age, gender, clinical,
histopathological, and radiological features, and surgical methods.



Results: There
were 24 patients with a mean age of 50.6 (23-66) years, consisting of 14 males
and 10 females, who underwent surgical resection for pulmonary hamartoma was.
While 17 (42%) patients were asymptomatic, the rest complained of coughing,
shortness of breath and repetitive lung infections. Hamartoma was localized in
the right lung in 16 (67%) of the cases; peripherally in 17 (71%), and
centrally in 7 (29%). All patients underwent wedge resection, 17 cases by
thoracoscopy and 7 cases by thoracotomy. The mean tumor diameter assessed
macroscopically was 2.9 cm (1-4.5cm).



Conclusion:
Pulmonary hamartomas frequently present as peripheral solitary nodules. Given
its low morbidity and mortality, surgical resection is recommended for
definitive diagnosis and treatment, the objective of the intervention being
total excision of the lesion while protecting the lung parenchyma.

References

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  • 2. Okudela K, Umeda S, Otara M, et all. A case of pulmonary hamartoma with distinctive histopathological features: a discussion of its differential diagnosis and histogenesis. Pathol Int 2014; 64: 618-23.
  • 3. Suut S, Al-Ani Z, Allen C, et all. Pictorial essay of radiological features of benign intrathoracic masses. Ann Thorac Med. 2015 Oct-Dec; 10: 231-42.
  • 4. Ekinci GH, Hacıömeroğlu O, Ersev A, et all. The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas. Rev Port Pneumol. 2017 Sep - Oct; 23: 280-6.
  • 5. An J, Long M, Jiang Y, Jin Y. Concomitant a giant pulmonary bulla on the left lower lobe and hamartoma successfully treated by video-assisted thoracoscopic pulmonary wedge resection. AME Case Rep. 2017 Sep 26; 1: 2.
  • 6. Abdel Hady SM, Elbastawisy SE, Hassaballa AS, Elsayed HH. Is surgical resection superior to bronchoscopic resection in patients with symptomatic endobronchial hamartoma? Interact Cardiovasc Thorac Surg. 2017 May 1; 24: 778-82.
  • 7. Dimitrakakis G, Challoumas D, Rama Rao Podila S, et all. The challenge of pulmonary endobronchial chondromatous hamartomas.J BUON. 2014 Jan-Mar; 19: 60-5.
  • 8. Elsayed H, Abdel Hady SM, Elbastawisy SE. Is resection necessary in biopsy-proven asymptomatic pulmonary hamartomas? Interact Cardiovasc Thorac Surg. 2015 Dec; 21: 773-6.
  • 9. Siegelman SS, Khouri NF, Scott WW, et all. Pulmonary hamartoma: CT findings. Radiology 1986; 160: 313-7.
  • 10. Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg 1967; 53: 735-42.
  • 11. Ledor K, Fish B, Chaise L, Ledor S. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr 1981; 5: 343-4.
  • 12. 9-Zehani-Kassar A, Ayadi-Kaddour A, Marghli A, et all. Clinical characteristics of resected bronchial hamartoma. Study of seven cases.Rev Mal Respir. 2011 May; 28: 647-53. 2011 Apr 16.
  • 13. Asad S, Aquino SL, Piyavisetpat N, Fischman AJ. False-positive FDG positron emission tomography uptake in nonmalignant chest abnormalities. AJR Am J Roentgenol 2004; 182: 983–9.
  • 14. ChristensenJA ,Nathan MA, Mullan BP, et all. Characterization of the solitary pulmonary nodule: 18F-FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol2006; 187: 1361–7.
  • 15. De Cicco C, Bellomi M, Bartolomei M, et all. Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg 2008; 86: 1769–72.
  • 16. Settas N, Faucz FR, Stratakis CA. Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome. Mol Cell Endocrinol. 2018 Jul 5; 469: 107-11.
  • 17. Boikos SA, Xekouki P, Fumagalli E, et all. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. Eur J Hum Genet 2016; 24: 569–73.
  • 18. Garofola C, Gross GP. Hamartoma, Cowden Disease (Multiple Hamartoma Syndrome). Stat Pearls TreasureIsland(FL):StatPearlsPublishing;2018-.2018 Oct 27.
  • 19. Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, et all. Hamartomas from head to toe: an imaging overview. Br J Radiol. 2017 Mar; 90 (1071): 20160607.
  • 20. von Ranke FM, Zanetti G, e Silva JL, et all. Tuberous sclerosis complex: state-of-the-art review with a focus on pulmonary involvement. Lung 2015; 193: 619–27.
  • 21. Xia Y, Wang KP.Transbronchial needle aspiration: where are we now? J Thorac Dis. 2013 Oct; 5: 678-82.
  • 22. Klein JS. Transthoracic needle aspiration biopsy for the cytologic diagnosis of subsolid lung nodules. Cancer Cytopathol. 2016 Jul; 124: 451-2.
  • 23. Serkan Bayram, Çağatay Tezel, Serdar Evman, ve ark. Sol ana bronş tümörüne sağ torakotomi ile izole sleeve rezeksiyon. Dicle Tıp Dergisi / Dicle Medical Journal 2017; 44: 119–23.
Year 2019, Volume: 46 Issue: 1, 27 - 32, 03.03.2019
https://doi.org/10.5798/dicletip.534820

Abstract

References

  • 1. Özlü T,Metintaş M,Kaya A. Solunum sistemi ve hastalıkları Temel başvuru kitabı.Cilt 2. (Respiratory system and its diseases – Reference book, Volume 2): Istanbul Medikal Yayıncılık 2010; 1511-12.
  • 2. Okudela K, Umeda S, Otara M, et all. A case of pulmonary hamartoma with distinctive histopathological features: a discussion of its differential diagnosis and histogenesis. Pathol Int 2014; 64: 618-23.
  • 3. Suut S, Al-Ani Z, Allen C, et all. Pictorial essay of radiological features of benign intrathoracic masses. Ann Thorac Med. 2015 Oct-Dec; 10: 231-42.
  • 4. Ekinci GH, Hacıömeroğlu O, Ersev A, et all. The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas. Rev Port Pneumol. 2017 Sep - Oct; 23: 280-6.
  • 5. An J, Long M, Jiang Y, Jin Y. Concomitant a giant pulmonary bulla on the left lower lobe and hamartoma successfully treated by video-assisted thoracoscopic pulmonary wedge resection. AME Case Rep. 2017 Sep 26; 1: 2.
  • 6. Abdel Hady SM, Elbastawisy SE, Hassaballa AS, Elsayed HH. Is surgical resection superior to bronchoscopic resection in patients with symptomatic endobronchial hamartoma? Interact Cardiovasc Thorac Surg. 2017 May 1; 24: 778-82.
  • 7. Dimitrakakis G, Challoumas D, Rama Rao Podila S, et all. The challenge of pulmonary endobronchial chondromatous hamartomas.J BUON. 2014 Jan-Mar; 19: 60-5.
  • 8. Elsayed H, Abdel Hady SM, Elbastawisy SE. Is resection necessary in biopsy-proven asymptomatic pulmonary hamartomas? Interact Cardiovasc Thorac Surg. 2015 Dec; 21: 773-6.
  • 9. Siegelman SS, Khouri NF, Scott WW, et all. Pulmonary hamartoma: CT findings. Radiology 1986; 160: 313-7.
  • 10. Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg 1967; 53: 735-42.
  • 11. Ledor K, Fish B, Chaise L, Ledor S. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr 1981; 5: 343-4.
  • 12. 9-Zehani-Kassar A, Ayadi-Kaddour A, Marghli A, et all. Clinical characteristics of resected bronchial hamartoma. Study of seven cases.Rev Mal Respir. 2011 May; 28: 647-53. 2011 Apr 16.
  • 13. Asad S, Aquino SL, Piyavisetpat N, Fischman AJ. False-positive FDG positron emission tomography uptake in nonmalignant chest abnormalities. AJR Am J Roentgenol 2004; 182: 983–9.
  • 14. ChristensenJA ,Nathan MA, Mullan BP, et all. Characterization of the solitary pulmonary nodule: 18F-FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol2006; 187: 1361–7.
  • 15. De Cicco C, Bellomi M, Bartolomei M, et all. Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg 2008; 86: 1769–72.
  • 16. Settas N, Faucz FR, Stratakis CA. Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome. Mol Cell Endocrinol. 2018 Jul 5; 469: 107-11.
  • 17. Boikos SA, Xekouki P, Fumagalli E, et all. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. Eur J Hum Genet 2016; 24: 569–73.
  • 18. Garofola C, Gross GP. Hamartoma, Cowden Disease (Multiple Hamartoma Syndrome). Stat Pearls TreasureIsland(FL):StatPearlsPublishing;2018-.2018 Oct 27.
  • 19. Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, et all. Hamartomas from head to toe: an imaging overview. Br J Radiol. 2017 Mar; 90 (1071): 20160607.
  • 20. von Ranke FM, Zanetti G, e Silva JL, et all. Tuberous sclerosis complex: state-of-the-art review with a focus on pulmonary involvement. Lung 2015; 193: 619–27.
  • 21. Xia Y, Wang KP.Transbronchial needle aspiration: where are we now? J Thorac Dis. 2013 Oct; 5: 678-82.
  • 22. Klein JS. Transthoracic needle aspiration biopsy for the cytologic diagnosis of subsolid lung nodules. Cancer Cytopathol. 2016 Jul; 124: 451-2.
  • 23. Serkan Bayram, Çağatay Tezel, Serdar Evman, ve ark. Sol ana bronş tümörüne sağ torakotomi ile izole sleeve rezeksiyon. Dicle Tıp Dergisi / Dicle Medical Journal 2017; 44: 119–23.
There are 23 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Miktat Arif Haberal This is me 0000-0002-1051-094X

Ozlem Sengoren Dikis This is me 0000-0001-7005-3333

Erkan Akar This is me 0000-0002-9113-8237

Publication Date March 3, 2019
Submission Date October 11, 2018
Published in Issue Year 2019 Volume: 46 Issue: 1

Cite

APA Haberal, M. A., Dikis, O. S., & Akar, E. (2019). Pulmonary hamartoma: Retrospective analysis of 24 cases. Dicle Tıp Dergisi, 46(1), 27-32. https://doi.org/10.5798/dicletip.534820
AMA Haberal MA, Dikis OS, Akar E. Pulmonary hamartoma: Retrospective analysis of 24 cases. diclemedj. March 2019;46(1):27-32. doi:10.5798/dicletip.534820
Chicago Haberal, Miktat Arif, Ozlem Sengoren Dikis, and Erkan Akar. “Pulmonary Hamartoma: Retrospective Analysis of 24 Cases”. Dicle Tıp Dergisi 46, no. 1 (March 2019): 27-32. https://doi.org/10.5798/dicletip.534820.
EndNote Haberal MA, Dikis OS, Akar E (March 1, 2019) Pulmonary hamartoma: Retrospective analysis of 24 cases. Dicle Tıp Dergisi 46 1 27–32.
IEEE M. A. Haberal, O. S. Dikis, and E. Akar, “Pulmonary hamartoma: Retrospective analysis of 24 cases”, diclemedj, vol. 46, no. 1, pp. 27–32, 2019, doi: 10.5798/dicletip.534820.
ISNAD Haberal, Miktat Arif et al. “Pulmonary Hamartoma: Retrospective Analysis of 24 Cases”. Dicle Tıp Dergisi 46/1 (March 2019), 27-32. https://doi.org/10.5798/dicletip.534820.
JAMA Haberal MA, Dikis OS, Akar E. Pulmonary hamartoma: Retrospective analysis of 24 cases. diclemedj. 2019;46:27–32.
MLA Haberal, Miktat Arif et al. “Pulmonary Hamartoma: Retrospective Analysis of 24 Cases”. Dicle Tıp Dergisi, vol. 46, no. 1, 2019, pp. 27-32, doi:10.5798/dicletip.534820.
Vancouver Haberal MA, Dikis OS, Akar E. Pulmonary hamartoma: Retrospective analysis of 24 cases. diclemedj. 2019;46(1):27-32.