Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Dilek Nartop; Elvan Hasanoğlu Özkan; Hatice Öğütçü; Nurdan Kurnaz Yetim

doi:10.29130/dubited.1402771

EN TR

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Abstract

In the present work, novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes (Hc1, Hc2, Hc3) were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques (element analysis, infrared spectra (IR), thermogravimetric analysis (TGA), organic elemental analysis, and magnetic susceptibility measurements). The biological activities of novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes werev screenedv in vitro against selected disease-causing pathogens (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonellav typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026, Candidav albicans Y-1200-NIH) were as potential antimicrobial agents. It was determined that the thiazole-based thiosemicarbazone Ag(I) complexes exhibited high or moderate antibacterial and antifungal activity.

Keywords

Ag(I) complex, Thiazole, Thiosemicarbazone, Biological activity

Supporting Institution

Düzce University Scientific Project (Project no: 2021.05.03.1215).

Ethical Statement

Not necessary

Thanks

This work is supported by Düzce University Scientific Project (Project no: 2021.05.03.1215).

Yeni Tiyazol Bazlı Tiyosemikarbazon Komplekslerinin Sentezi ve in vitro Biyolojik Değerlendirmeleri

Abstract

Sunulan bu çalışmada, yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) kompleksleri (Hc1, Hc2, Hc3) template yöntem ile elde edildi. Sentezlenen tiyosemikarbazon bileşiklerinin yapıları bazı spektroskopik teknikler (element analizi, infrared spektra (IR), termogravimetrik analiz (TGA), organic elemental analiz, ve magnetik duyarlılık ölçümleri) ile karakterize edildi. Yeni heterosiklik tiyazol bazlı tiyosemikarbazon Ag(I) komplekslerinin biyolojik aktiviteleri potansiyel antimikrobiyal ajanlar olarak seçilmiş hastalık yapıcı patojenlere (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteusv vulgaris RSKK96026, Candida albicans Y-1200-NIH) karşı in vitro olarak incelendi.

Keywords

Ag(I) kompleksi, Tiyazol, Tiyosemikarbazon, Biyolojik aktivite

Supporting Institution

Düzce University Scientific Project (Project no: 2021.05.03.1215)Üniversitesi

Ethical Statement

Gerekli değil

Thanks

Bu çalışma Düzce Üniversitesi Blilmsel Araştırma Projesi tarafondan desteklenmiştir (Project no: 2021.05.03.1215).

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Details

Primary Language

English

Subjects

Physical Chemistry (Other)

Journal Section

Research Article

Authors

Dilek Nartop ^*
0000-0002-0705-5018
Türkiye

Elvan Hasanoğlu Özkan
0000-0001-7338-4015
Türkiye

Hatice Öğütçü
0000-0001-7100-9318
Türkiye

Nurdan Kurnaz Yetim
0000-0001-6227-0346
Türkiye

Publication Date

July 31, 2024

Submission Date

December 10, 2023

Acceptance Date

February 16, 2024

Published in Issue

Year 2024 Volume: 12 Number: 3

DOI

https://doi.org/10.29130/dubited.1402771

IZ

https://izlik.org/JA98XR37DG

APA

Nartop, D., Hasanoğlu Özkan, E., Öğütçü, H., & Kurnaz Yetim, N. (2024). Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes. Duzce University Journal of Science and Technology, 12(3), 1389-1397. https://doi.org/10.29130/dubited.1402771

AMA

1.Nartop D, Hasanoğlu Özkan E, Öğütçü H, Kurnaz Yetim N. Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes. DUBİTED. 2024;12(3):1389-1397. doi:10.29130/dubited.1402771

Chicago

Nartop, Dilek, Elvan Hasanoğlu Özkan, Hatice Öğütçü, and Nurdan Kurnaz Yetim. 2024. “Synthesis and in Vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes”. Duzce University Journal of Science and Technology 12 (3): 1389-97. https://doi.org/10.29130/dubited.1402771.

EndNote

Nartop D, Hasanoğlu Özkan E, Öğütçü H, Kurnaz Yetim N (July 1, 2024) Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes. Duzce University Journal of Science and Technology 12 3 1389–1397.

IEEE

[1]D. Nartop, E. Hasanoğlu Özkan, H. Öğütçü, and N. Kurnaz Yetim, “Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes”, DUBİTED, vol. 12, no. 3, pp. 1389–1397, July 2024, doi: 10.29130/dubited.1402771.

ISNAD

Nartop, Dilek - Hasanoğlu Özkan, Elvan - Öğütçü, Hatice - Kurnaz Yetim, Nurdan. “Synthesis and in Vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes”. Duzce University Journal of Science and Technology 12/3 (July 1, 2024): 1389-1397. https://doi.org/10.29130/dubited.1402771.

JAMA

1.Nartop D, Hasanoğlu Özkan E, Öğütçü H, Kurnaz Yetim N. Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes. DUBİTED. 2024;12:1389–1397.

MLA

Nartop, Dilek, et al. “Synthesis and in Vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes”. Duzce University Journal of Science and Technology, vol. 12, no. 3, July 2024, pp. 1389-97, doi:10.29130/dubited.1402771.

Vancouver

1.Dilek Nartop, Elvan Hasanoğlu Özkan, Hatice Öğütçü, Nurdan Kurnaz Yetim. Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes. DUBİTED. 2024 Jul. 1;12(3):1389-97. doi:10.29130/dubited.1402771

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Abstract

Keywords

Supporting Institution

Ethical Statement

Thanks

Yeni Tiyazol Bazlı Tiyosemikarbazon Komplekslerinin Sentezi ve in vitro Biyolojik Değerlendirmeleri

Abstract

Keywords

Supporting Institution

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite