In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers

Year 2020, Volume: 8 Issue: 1, 693 - 701, 31.01.2020

Serhat Keser , Fatma Keser Suat Tekın Ömer Kaygılı , İsmail Turkoglu , Ersin Demır , Mustafa Karatepe , Sevda Kırbag , Ökkes Yılmaz , Suleyman Sandal , Semra Turkoglu

https://doi.org/10.29130/dubited.595147

Cited By: 3

Abstract

Alcea calvertii (Boiss) Boiss.
is belonged to Malvaceae family, and it is a perennial herbaceous endemic
plant. Alcea genus plants are grown
as ornamental plants in the gardens. In the present study, the antiproliferative,
antimicrobial, antiradical activities and phytochemical compositions of
ethanol, water, methanol and acetone extracts of A. calvertii flowers were examined. A. calvertii flowers water, ethanol, methanol and acetone extracts
are lower scavenged DPPH, ABTS and OH radicals than standard antioxidant
trolox. A. calvertii flowers contain
vitamins, sterols, flavonoids and phenolic acids, dominated by vanillic acid,
gallic acid, catechin, δ-tocopherol, ergosterol and vitamin D. A. calvertii
flowers water extract showed better antiproliferative activities than other
extracts against to MCF-7 and HCT-116 cell lines. A. calvertii flowers methanol extract showed higher
antiproliferative effect against to LNCaP cell lines.

Keywords

Alcea calvertii, antiradical, antimicrobial, antiproliferative, phytosterol

Supporting Institution

TÜBİTAK

Project Number

114Z124

Thanks

The TUBITAK was supported this study with under grant project number 114Z124.

Endemik Alcea calvertii (Boiss) Boiss. Çiçeklerinin In vitro Antiradikal, Antimikrobiyal ve Antiproliferatif Aktiviteleri ve Fitokimyasal Kompozisyonu

Abstract

Alcea calvertii (Boiss) Boiss. Malvaceae familyasında yer alan çok yıllık otsu
endemik bir bitkidir. Alcea genusuna
ait bitkiler bahçelerde süs bitkileri olarak yetiştirilirler. Sunulan
çalışmada, Alcea calvertii
çiçeklerinin su, etanol, metanol ve aseton ekstraktlarının antiproliferatif,
antimikrobiyal, antiradikal aktiviteleri ve fitokimyasal kompozisyonları
incelendi. A. calvertii çiçeklerinin su,
etanol, metanol ve aseton ekstraktlarının standart antioksidan trolokstan daha
düşük oranda DPPH, ABTS ve OH radikali yok ettiği saptandı. A. calvertii çiçeklerinin vitamin, sterol, flavonoit ve fenolik
asitler içerdiği ve yüksek miktarda vanillik asit, gallik asit, kateşin, δ-tokoferol,
ergosterol ve vitamin D içerdiği belirlendi.
A. calvertii su ekstraktının MCF-7 ve HCT-116 kanser hücrelerine karşı
diğer ektstraktlardan daha iyi antiproliferatif aktivite gösterdiği gözlendi. LNCaP
hücre serilerine karşı ise A. calvertii
metanol ekstraktı daha yüksek antiproliferatif aktivite gösterdi.

Keywords

Alcea calvertii, antiradikal, antimikrobiyal, antiproliferatif, fitosterol

Project Number

114Z124

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