Can Urolitin-A Alter Latent Clearance Scores and the Number of Diarrheal Daysin Calves?

Abstract

Urolitin-A (Ur-a) is a compound produced by the metabolism of natural polyphenols ellagitannins and ellagic acid by the intestinal microbiota. In this study, the effects of Ur-a on fecal consistency (fC) and latent cleanliness (lC) scores in calves with non-infectious diarrhea were evaluated. A nutraceutical preparation containing Ur-a was administered orally to 57 Holstein calves at a dose of 50 mg/kg. As a result of the study, after Ur-a administration, fC scores decreased from the initial 2-3 range to the 0-1 range. Similarly, lC scores decreased from the initial 1-3 values to the 0-1 levels and this change was found to be statistically significant (p<0.001). In addition, it was observed that the calves recovered from diarrhea at different time periods. Considering the antioxidant, anti-inflammatory and immunomodulatory properties of Ur-a, it would be appropriate to suggest that it can be used as a potential agent in the supportive treatment of non-infectious calf diarrhea.

Keywords

• Calf
• diarrhea
• latent clearance score
• non-infectious
• urolithin-a

Ürolitin-A Buzağılarda Gizli Temizlik Skorlarında ve Diyareik Günlerin Sayısında Değişim Sağlayabillir Mi?

Öz

Ürolitin-A (Ür-a), doğal polifenoller olan elajitanninlerin ve ellagik asitin bağırsak mikrobiyotası tarafından metabolize edilmesiyle üretilen bir bileşiktir. Bu çalışmada, Ür-a’nın non-enfeksiyöz diyareli buzağılarda dışkı kıvamı (dK) ve gizli temizlik (gT) skorları üzerindeki etkileri değerlendirildi. Holştayn ırkı 57 buzağıya oral yolla 50 mg/kg dozunda Ür-a içeren nutrasötik müstahzar uygulandı. Çalışma sonucunda, Ür-a uygulaması sonrası dK skorları başlangıçtaki 2-3 aralığından 0-1 aralığına geriledi. Benzer şekilde, gT skorları başlangıçtaki 1-3 değerlerinden 0-1 seviyelerine düştü ve bu değişim istatistiksel olarak anlamlı bulundu (p<0.001). Ayrıca, buzağıların farklı zaman dilimlerinde ishalden kurtulduğu gözlemlendi. Ür-a’nın antioksidan, anti-inflamatuvar ve immünmodülatör özellikleri göz önüne alındığında, non-enfeksiyöz buzağı ishallerinin destekleyici tedavisinde potansiyel bir ajan olarak kullanılabileceğini öne sürmek yerinde olacaktır.

Anahtar Kelimeler

• Buzağı
• diyare
• gizli temizlik skoru
• non-enfeksiyöz
• ürolitin-a

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