Investigation of radiosensitivity of gamma irradiated procaine hydrochloride in the solid state

Year 2017, , 314 - 318, 30.09.2017

Şemsettin Osmanoğlu

https://doi.org/10.31202/ecjse.310494

Cited By: 1

Abstract

Dosimetric properties of
gamma-irradiated procaine hydrochloride
were investigated at room temperature by Electron Paramagnetic Resonance
technique. No signal was obtained on the non-irradiated samples; however
significant signals were obtained from the samples irradiated with gamma at
certain doses.  Mathematical functions
and correlation coefficients were calculated determining the relation between
the increasing radiation doses on the signal intensities of the sample. The
free radicals were appeared to be stable at room temperature for more than 200
days. 

Keywords

Electron Paramagnetic Resonance, Gamma Irradiation

References

• [1] Crucq, A.S., Slegers, C., Deridder, V., Tilquin, B., 2000, Radiosensitivity study of cefazolin sodium. Talanta, 52, 873-877.
• [2] Sütçü, K., Osmanoğlu, Y.E., Akbalık, F., 2016, Investigation of radiosensitivity of gamma irradiated isoniazid antibiotic through epr spectroscopy. Anadolu Unv. J. Sci. Tech. A, 17, 735-740.
• [3] Desroisers, M.C., 1996, Current status of the EPR method to detect irradiated food. Appl. Radiat. Isot., 47, 1621-1628.
• [4] Petrişor, D., Damian, G., Simon, S., 2008, Gamma-irradiated ExtraVit M nutritive supplement studied by electron paramagnetic resonance spectroscopy. Radiat. Phys. Chem., 77, 463-468.
• [5] Sütçü, K., Osmanoğlu, Y.E., 2017, The effect of gamma radiation on some succinic acid derivatives in the solid state. J. Mol. Struct., 1127, 476-478.
• [6] Osmanoğlu, Y.E., Sütçü, K., 2017, EPR studies of the free radicals generated in gamma irradiated amino acid derivatives. J. Mol. Struct., 1145, 240-243.
• [7] Basly, J.P., Longy, I., Bernard, M., 1997, Influence of radiation treatment on two antibacterial agents and four antiprotozoal agents: ESR dosimetry. Int. J. Pharma., 154, 109-113.
• [8] Basly, J.P., Bernard, M., 1997, Radio sterilization dosimetry by ESR spectroscopy: Ritodrine hydrochloride and comparison with other sympathomimetics. Int. J. Pharma., 149, 85-91.
• [9] Delincee, H., 2002, Analytical methods to identify irradiated food—a review. Radiat. Phys. Chem., 63, 455-458.
• [10] Murieta, H., Munoz, E., Adem, E., Burillo, G., Vazquez, M., Cabrera, E., 1996, Effect of irradiation dose, storage time and temperature on the ESR signal in irradiated oat, and corn and wheat. Appl. Radiat. Isot., 47, 1657-1661.
• [11] Ambroż, H. B., Kornacka, E. M., Marciniec, B., Ogrodowczyk, M., Przybytniak, G. K., 2000, ). EPR study of free radicals in some drugs γ-irradiated in the solid state. Radiat. Phys. Chem., 58(4), 357-366.
• [12] Karadaş, Ö., Köroğlu Omaç, Ö., Tok, F., Özgül, A., Odabaşı, Z., 2012, Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: an ultrasonographic study. J.Neurol. Sci., 316, 76-78.
• [13] Adam, A.B., 2012, Synthesis, spectroscopic, thermal and antimicrobial investigations of charge-transfer complexes formed from the drug procaine hydrochloride with quinol, picric acid and TCNQ. J. Molec. Struc., 1030, 26-39.
• [14] Latosińska, J.N., Pietrzak, J. 2004, EPR study of free radicals in γ-irradiated thiazide compounds. Appl. Magn. Res. 26, 345-355.
• [15] Damian, G., Miclăuş, V., 2005, Study of free radicals in gamma-irradiated metoclopramide using spin trapping ESR spectroscopy. Rom. J. Biophys, 15, 121-126.
• [16] Basly, J.P., Basly, I., Bernard, M., 1998, Electron spin resonance identification of irradiated ascorbic acid: dosimetry and influence of powder fineness. Anal. Chim Acta. 372, 373-378.
• [17] Basly, J.P., Longy, I., Bernard, M., 1997, Electron spin resonance identification of irradiated ascorbic acid: dosimetry and influence of powder fineness. Int. J. Pharma., 158, 241-245.
• [18] Basly, J.P., Longy, I., Bernard, M., 1998, Electron spin resonance identification of irradiated ascorbic acid: dosimetry and influence of powder fineness. Anal. Chim Acta, 158, 107-113.
• [19] Sütçü, K., Osmanoğlu, Y.E., 2017, Study of dose-response and radical decay curves of gamma irradiated norfloxacin using EPR spectroscopy. AIP. Conf. Proc.1815, 09003-05.