Recent Advances in the Diagnosis, Pathogenesis and Treatment of Vitiligo: A Review

Abstract

Vitiligo is a condition that affects approximately 1-2 out of every 100 people in the general population and can lead to significant psychosocial burdens. Both genetic and environmental factors are implicated in its etiology. While genetic factors are estimated to account for about 75% of disease development, the remaining portion is attributed to environmental influences. Vitiligo is generally classified as either segmental or non-segmental. Segmental vitiligo is less common, tends to remain stable, and is more resistant to treatment. Non-segmental vitiligo, on the other hand, is more progressive and more frequently encountered. Clinically, vitiligo is characterized by depigmented macules and patches. Although diagnosis is typically made clinically, additional methods such as Wood’s lamp examination, dermoscopy, and biopsy may occasionally be employed. Vitiligo must be differentiated from other conditions that cause depigmented or hypopigmented lesions, which can usually be distinguished through further evaluation by a dermatologist. A wide range of treatment options are available, with topical and systemic medications and phototherapy being the most commonly used approaches. In addition to long-established and evidence-based therapies, various novel treatments are currently under investigation. As our understanding of the disease continues to grow, it is clear that innovative therapies will emerge to improve vitiligo management.

Keywords

• Vitiligo
• advances
• treatment

Vitiligo Patogenez, Tanı ve Tedavisinde Güncel Gelişmeler: Bir Gözden Geçirme

Abstract

Vitiligo, toplumda ortalama 100 kişiden 1-2’sini etkileyen ve ciddi psikososyal yüklere neden olabilen bir hastalıktır. Klinik olarak depigmente makül ve yamalarla karakterizedir. Etiyolojisinde genetik ve çevresel faktörler suçlanmaktadır. Vitiligo genel olarak segmental ve non-segmental olarak sınıflandırılır. Segmental vitiligo daha nadir görülen, stabil kalma eğiliminde olan ve tedaviye daha zor yanıt veren türdür. Non-segmental vitiligo ise daha ilerleyici olan ve sık görülen alt tiptir. Tanısı genelde klinik olarak konulmakla birlikte Wood incelemesi, dermatoskopi, biyopsi gibi yöntemlere de nadiren başvurulabilmektedir. Vitiligo, depigmente bazen de hipopigmente lezyonlara sebep olan birçok hastalık ile ayırıcı tanıya girmektedir. Tedavide birçok farklı seçenek bulunmaktadır. Topikal ve sistemik ilaçlar ve fototerapi en sık kullanılanlardır. Uzun süredir kullanılan ve etkileri kanıtlanmış tedaviler dışında günümüzde hala çalışmaları devam eden birçok farklı ilaç bulunmaktadır. Özellikle son yıllarda topikal ve sistemik JAK inhibitörleri ile ilgili çok sayıda çalışma yapılmaktadır. Artan bilgi birikimi ile birlikte vitiligo tedavisinde ilerleme sağlanacak yeniliklerin geliştirileceği açıktır.

Keywords

• Vitiligo
• tedavi
• gelişmeler

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