The Prognostic Value of Inflammatory Indices and the HALP Score in Aortic Dissection

Abstract

Introduction: Aortic dissection is critical, and recent studies increasingly highlight the prognostic value of laboratory parameters alongside diagnostic CT angiography. Materials and Methods: This study included 23 adult patients diagnosed with aortic dissection between January 2023 and January 2025, analyzing the association between admission lab data, derived scores, and outcomes like mortality and ICU stay. Results: Neutrophil count was found to be significantly higher in patients who died (p = 0.03), with 57.1% sensitivity and 68.8% specificity in predicting mortality. A significant negative correlation was found between HALP score and ICU length of stay (r = –0.471, p = 0.023), whereas CRP levels were positively correlated with ICU stay duration (r = 0.504, p = 0.014). Conclusion: Neutrophil count, HALP score, and CRP levels may serve as useful biomarkers for predicting the prognosis of aortic dissection and aiding early risk stratification

Keywords

• HALP score
• Aortic dissection
• prognosis

Supporting Institution

none

Ethical Statement

This study was conducted with the approval of the Scientific Research Ethics Committee of Malatya Turgut Özal University, Faculty of Health Sciences(2025/40). Since no personal data were used in this study, informed consent was not required.

Thanks

none

Akut Aort Diseksiyonunda İnflamatuvar İndeksler ve HALP Skorunun Prognostik Değeri

Abstract

Giriş: Aort diseksiyonu kritik bir klinik tablodur ve son yıllarda yapılan çalışmalar, tanısal BT anjiyografinin yanında laboratuvar parametrelerinin prognostik değerini giderek daha fazla vurgulamaktadır. Gereç ve Yöntem: Bu çalışmaya Ocak 2023 – Ocak 2025 tarihleri arasında aort diseksiyonu tanısı alan 23 erişkin hasta dâhil edilmiştir. Hastaların başvuru anındaki laboratuvar verileri ve bu verilerden türetilen skorlar ile mortalite ve yoğun bakım yatış süresi gibi klinik sonuçlar arasındaki ilişki değerlendirilmiştir. Bulgular: Mortalite gelişen hastalarda nötrofil sayısı anlamlı olarak daha yüksek bulunmuştur (p = 0.03) ve mortaliteyi öngörmede %57.1 duyarlılık ve %68.8 özgüllük göstermiştir. HALP skoru ile yoğun bakım yatış süresi arasında anlamlı negatif korelasyon saptanmıştır (r = –0.471, p = 0.023). Buna karşılık, CRP düzeyleri ile yoğun bakımda kalış süresi arasında anlamlı pozitif korelasyon mevcuttur (r = 0.504, p = 0.014). Sonuç: Nötrofil sayısı, HALP skoru ve CRP düzeyleri, aort diseksiyonunun prognozunun öngörülmesinde ve erken risk sınıflandırmasında yararlı biyobelirteçler olarak kullanılabilir.

Keywords

• HALP skoru
• aort diseksiyonu
• prognoz

Supporting Institution

yok

Ethical Statement

Bu çalışma, Malatya Turgut Özal Üniversitesi Sağlık Bilimleri Bilimsel Araştırmalar Etik Kurulu onayı(2025/40) ile gerçekleştirilmiştir. Çalışmada kişisel veriler kullanılmadığından hasta onamı alınmamıştır.

Thanks

yok

References

1. Yao, Jian, et al. "The diagnostic value of D-dimer in acute aortic dissection: a metaanalysis." Journal of cardiothoracic surgery 16.1 (2021): 343.
2. Wundram, Maximilian, et al. "Incidence of acute type A aortic dissection in emergency departments." Scientific reports 10.1 (2020): 7434.
3. Milewicz, Dianna M., and Francesco Ramirez. "Therapies for thoracic aortic aneurysms and acute aortic dissections: old controversies and new opportunities." Arteriosclerosis, thrombosis, and vascular biology 39.2 (2019): 126-136.
4. Wolford, Brooke N., et al. "Clinical implications of identifying pathogenic variants in individuals with thoracic aortic dissection." Circulation: Genomic and Precision Medicine 12.6 (2019): e002476.
5. Zhou, Changping, et al. "Anxa1 in smooth muscle cells protects against acute aortic dissection." Cardiovascular research 118.6 (2022): 1564-1582.
6. Wang, Xinhao, et al. "The role of macrophages in aortic dissection." Frontiers in physiology 11 (2020): 54.
7. Carrel, Thierry, et al. "Acute aortic dissection." The Lancet 401.10378 (2023): 773-788
8. Fleischmann, Dominik, et al. "Imaging and surveillance of chronic aortic dissection: a scientific statement from the American Heart Association." Circulation: Cardiovascular Imaging 15.3 (2022): e000075.

9. Smedberg, Christian, et al. "Sex differences and temporal trends in aortic dissection: a populationbased study of incidence, treatment strategies, and outcome in Swedish patients during 15 years." European heart journal 41.26 (2020): 2430-2438.
10. Gudbjartsson, Tomas, et al. "Acute type A aortic dissection–a review." Scandinavian Cardiovascular Journal 54.1 (2020): 1-13.
11. Murillo, Horacio, et al. "Aortic dissection and other acute aortic syndromes: diagnostic imaging findings from acute to chronic longitudinal progression." Radiographics 41.2 (2021): 425-446.
12. Salmasi, M. Yousuf, et al. "The risk of misdiagnosis in acute thoracic aortic dissection: a review of current guidelines." Heart 106.12 (2020): 885-891.
13. Deplano, Valerie, et al. "Mechanical characterisation of human ascending aorta dissection." Journal of Biomechanics 94 (2019): 138-146.
14. Eliathamby, Daniella, et al. "Ascending aortic length and its association with type A aortic dissection." Journal of the American Heart Association 10.13 (2021): e020140
15. Chaddha, Ashish, et al. "Survivors of aortic dissection: activity, mental health, and sexual function." Clinical Cardiology 38.11 (2015): 652-659.
16. Hatzaras, Ioannis S., et al. "Role of exertion or emotion as inciting events for acute aortic dissection." The American journal of cardiology 100.9 (2007): 1470-1472.
17. Heuts, Samuel, et al. "Aortic elongation part II: the risk of acute type A aortic dissection." Heart 104.21 (2018): 1778-1782.