Manyetik Alana Duyarlı poli(AAm-VSA)-PVA/Fe3O4 Nanokürelerin Sentezlenmesi ve AMF Altında İlaç Salım Davranışlarının İncelenmesi

Abstract

Polimer ile kaplanmış manyetik nano partiküllerin, başta biyomedikal bilimlerin uygulamaları olmak üzere birçok alanda büyük kullanım potansiyeline sahip malzemeler haline geldiği görülmektedir. Bu çaşılmada, kabuk-çekirdek yapısında Poli(AAm-VSA)-PVA/Fe3O4 nanoküreler sentezlenmiş, sentezlenen bu sistemlere ilaç yüklemesi yapılarak çeşitli büyüklüklerdeki alternatif manyetik alan (AMF) altında ilaç salım kinetikleri incelenmiştir. Çalışmanın ilk kısmında, birlikte çöktürme yöntemi ile nano boyutta Fe3O4 manyetik nano partikülleri sentezlenmiştir. Sentezlenen bu Fe3O4 nano partiküllerini polimer ile kaplamak için, Akrilamid (AAm) ve Vinilsülfonik asitin (VSA) Polivinilalkol (PVA) ortamında emülsiyon polimerizasyonu yöntemi kullanılmıştır. Bu yöntem ile kabuk çekirdek yapısında nano küreler elde edilmiştir. Elde edilen sistemlerin yapısal karakterizasyonları için FT-IR, TGA ve TEM analizleri yapılmıştır. İkinci aşamada ise bu nano kürelere ilaç yüklemesi yapılarak çeşitli şiddetlerdeki AMF altında ilaç salım kinetikleri incelenmiştir. Sentezlenen poli(AAm-VSA)-PVA/Fe3O4 nanopartikülleri AMF büyüklüğünün armasıyla altında daha hızlı ısınma ve ilaç salım davranışı sergilemiştir.

Keywords

• Nano manyetik taşıyıcı sistemler
• İlaç salımı
• İndüksiyon ile ısıtma

Synthesis of Magnetic Field Sensitive poly(AAm-co-VSA)-PVA/Fe3O4 Nanospheres and Investigation of Their Drug Release Behaviors Under AMF

Abstract

It is seen that magnetic nanoparticles coated with polymer have become materials with great potential of use in many fields, especially in the applications of biomedical sciences. In this study, poly(AAm-VSA)-PVA/Fe3O4 nanospheres in shell-core structure were synthesized, drug loading was made to these synthesized systems and the release kinetics of the loaded drug under alternative magnetic field (AMF) of various sizes were investigated. In the first part of the study, Fe3O4 magnetic nanoparticles of nano size were synthesized by co-precipitation method. Emulsion polymerization method of Acrylamide (AAm) and Vinylsulfonic acid (VSA) in Polyvinylalcohol (PVA) medium was used to coat these synthesized Fe3O4 nanoparticles with polymer. With this method, nanospheres in shell core structure were obtained. FT-IR, TGA and TEM analyzes were performed for the structural characterization of the systems obtained. In the second stage, drug release kinetics were investigated under AMF of various intensities by loading drugs into these nanospheres. Synthesized poly(AAm-co-VSA)-PVA/Fe3O4 nanoparticles exhibited faster warming and drug release behavior with increasing AMF intensity.

Keywords

• Nano magnetic carrier systems
• drug release
• induction heating

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