İneklerde Postpartum Dönemdeki Hastalıklarda Sitokin Düzeyleri

Abstract

Periparturient dönemde, süt sentezinin başlaması ve yem tüketiminin azalması sonucu enerji ihtiyacının artması, ineklerde negatif enerji dengesinin (NED) ortaya çıkmasına neden olur. İneklerin NED’e uyum sağlayamaması sonucu, yağlı karaciğer ve ketozis gibi metabolik hastalıklar ortaya çıkmaktadır. Karaciğer yağlanması sonucu ketozis, aboma-sum deplasmanı, metritis gibi hastalıklar, immün sistemin baskılanması ve reprodüktif performansta azalma görülmek-tedir. Süt ineklerinin bu dönemde maruz kaldıkları metabolik stres hem doğal hem de kazanılmış bağışıklık üzerinde birçok olumsuzluklara sebep olmaktadır. Hem doğal hem de kazanılmış bağışıklık sisteminin düzenli çalışması için gerekli bir molekül olan sitokinlerin organizmadaki birçok önemli fizyolojik ve patolojik olayda görevleri vardır. Sitokinler fonksiyonlarına göre proinflamatuvar ve antiinflamatuvar olarak sınıflandırılabilir. Proinflamatuvar sitokinler (İnterlökin-1 Beta (IL-1β), Tümör Nekrozis Faktör-Alfa (TNF-α), IL-6, IL-15, IL-8) özellikle lökositleri aktive ederek organizmanın patojen mikroorganizmalara ve tümörlere karşı savunmasında rol alırlar. Antiinflamatuvar sitokinler ise (IL-4, IL-10, IL-13) inflamatuvar cevabı sınırlandırırlar. Bu derlemede, süt inekçiliğinde periparturient dönemdeki immün sistem fonksi-yonlarının önemli göstergelerinden biri olan sitokin konsantrasyonlarının, metabolik değişiklikler ve bu dönemde gözle-nen hastalıklarla arasındaki ilişkisi hakkında bilgi verilmesi amaçlandı.

Keywords

• İnek
• periparturient
• sitokin

Cytokine Levels of Diseases in Postpartum Period in Cows

Abstract

The increase in energy requirement as a result of the start of milk synthesis and decrease in feed con-sumption causes negative energy balance (NEB) in cows in periparturient period. Inability to adapt to the NEB results in metabolic diseases such as fatty liver and ketosis. Ketosis, abomasum displacement, metritis, immune system sup-pression and decrease in reproductive performance are seen as a result of fatty liver. The metabolic stress experi-enced by dairy cows during this period causes dysfunction in many ways on both natural and acquired immunity. The metabolic stress of dairy cows during this period cause many negative effects on both natural and acquired immunity. Cytokines, a molecule necessary for the functioning of both the innate and acquired immune system, have roles in many important physiological and pathological events in the organism. Cytokines can be classified as pro-inflammatory and anti-inflammatory according to their functions. Pro-inflammatory cytokines (Interleukine-1 Beta (IL-1β), Tumor Ne-crosis Factor Alpha (TNF-α), IL-6, IL-15, IL-8) play a role in the defence of the organism against pathogenic microor-ganisms and tumours, in particular by activating leukocytes. Anti-inflammatory cytokines (IL-4, IL-10, IL-13) limit the inflammatory responses. In this review, it was aimed to give information about cytokine concentrations, which is one of the important indicators of immune system functions in dairy cattle periparturient period, its relationship with metabolic changes and diseases observed during this period.

Keywords

• Cow
• cytokine
• periparturient

References

1. Baştan A. İneklerde Meme Sağlığı ve Sorunları. İkinci Baskı. Kardelen Ofset: Ankara, 2013; s. 399.
2. Beagley JC, Whitman KJ, Baptiste KE, Scherzer J. Physiology and treatment of retained fetal memb-ranes in cattle. J Vet Intern Med 2010; 24(2): 261-8.
3. Bertoni G, Trevisi E. Use of the liver activity index and other metabolic variables in the assessment of metabolic health in dairy herds. Vet Clin N Am 2013; 29: 413-31.
4. Bobe G, Young JW, Beitz DC. Invited review: Patho-logy, etiology, prevention, and treatment of fatty liver in dairy cows. J Dairy Sci 2004; 87(10): 3105-24.
5. Bondurant RH. Inflamation in the bovine female rep-roductive tract. J Anim Sci 1999; 77: 101-10.
6. Boro P, Kumaresan A, Singh AK, Gupta D, Kumar S, Manimaran A, Mohanty AK, Mohanty TK, Pathak R, Attupuram NM, Baithalu RK, Prasad S. Expression of short chain fatty acid receptors and pro-inflammatory cytokines in utero-placental tissues is altered incows developing retention of fetal membranes. Placenta 2014; 35: 455-60.
7. Butterfield TA, Best TM, Merrick MA. The dual roles of neutrophils and macrophages in inflammation: A critical balance between tissue damage and repair. J Athl Train 2006; 41: 457-65.
8. Caro-Maldonado A, Wang R, Nichols AG. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol 2014; 192: 3626-36.

9. Dantzer R, Kelley KW. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 2007; 21: 153-60.
10. Dervishi E, Zhang G, Hailemariam D, Goldansaz SA, Deng Q, Dunn SM, Ametaj BN. Alterations in inni-ate immunity reactans and carbonhydrate and lipit metabolism precede occurence of metritis in tran-sition dairy cows. Res Vet Sci 2016; 104: 30-9.
11. Dhaliwal G, Murray R, Woldehiwet Z. Some aspects of immunology of the bovine uterus related to treatments for endometritis. Anim Reprod Sci 2001; 67(3-4): 135-52.
12. Drackley JK. Biology of dairy cows during the transi-tion period: The final frontier? J Dairy Sci 1999; 82(11): 2259-73.
13. El-Deeb WM, El-Bahr SM. Biomarkers of ketosis in dairy cows at postparturient period: Acute phase proteins and pro-inflammatory cytokines. Vet Arhiv 2017; 87: 431-40.
14. Fecteau KA, Eiler H. Placenta detachment: Unexpec-ted high concentrations of 5-hydroxytryptamine (serotonin) in fetal blood and its mitogenic effect on placental cells in the bovine. Placenta 2001; 22: 103-10.
15. Fischer C, Drillich M, Odau S, Heuwieser W, Einspa-nier R, Gabler C. Selected pro-inflammatory fac-tor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endomet-ritis. Reprod Fertil Dev 2010; 22: 818-29.
16. Földi J, Kulcsar M, Pecsı A, Huyghe B, De Sa C, Lohuis JA, Cox P, Huszenicza G. Bacterial complications of postpartum uterine involution in cattle. Anim Reprod Sci 2006; 96: 265-81.
17. Galvão KN, Santos NR, Galvão JS, Gilbert RO. As-sociation between endometritis and endometrial cytokine expression in postpartum Holstein cows. Theriogenology 2011; 76: 290-9.
18. Ghasemi F, Gonzales-Cano P, Griebel PJ, Palmer C. Proinflamatory cytokine gene expression in endo-metrial cytobrush samples harvested from cows with and without subclinical endometritis. Theriogenology 2012; 78: 1538-47.
19. Hammon DS, Evjen IM, Dhiman TR, Goff JP, Walters JL. Neutrophil function and energy status in Hols-tein cows with uterine health disorders. Vet Immunol Immunopathol 2006; 113(1-2): 21-9.
20. Hayırlı A, Çolak A. İneklerin kuru ve geçiş dönemle-rinde sevk-idare ve besleme stratejileri: post-partum süreçte metabolik profil, sağlık durumu ve fertiliteye etkisi. Turkiye Klinikleri J Vet Sci 2011; 2(1): 1-35.
21. Herdt TH. Ruminant adaptation to negative energy balance: Influences on the etiology of ketosis and fatty liver. Vet Clin North Am Food Anim Pract 2000; 16(2): 215-30.
22. Husain Z, Huang Y, Seth P, Sukhatme VP. Tumor-derived lactate modifies antitumor immune res-ponse: effect on myeloidderived suppressor cells and NK cells. J Immunol 2013; 191: 1-10.
23. Jabbour HN, Sales KJ, Catalano RD, Norman JE. Inflammatory pathways in female reproductive health and disease. Reproduction 2009; 138(6): 903-19.
24. Kasimanickam RK, Kasimanickam VR, Olsen JR, Jeffress EJ, Moore DA, Kastelic JP. Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. Reprod Biol Endocrinol 2013; 11: 103.
25. Kauf, AC, Rosenbusch RF, Paape MJ, Bannerman DD. Innate immune response to intramammary Mycoplasma bovis infection. J Dairy Sci 2007; 90: 3336-48.
26. Kım IH, Na KJ, Yang MP. Immune responses during the peripartum period in dairy cows with post-partum endometritis. J Reprod Dev 2005; 51: 757-64.
27. Kiely A, McClenaghan NH, Flatt RR, Newsholme P. Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic β-cell line. J Endocrinol 2007; 195: 113-23.
28. Kimura K, Goff JP, Kehrli ME, Reinhardt TA. Decrea-sed neutrophil function as a cause of retained placenta in dairy cattle. J Dairy Sci 2002; 85: 544-50.
29. Koj A. Termination of acute-phase response: role of some cytokines and antiinflammatory drugs. Gen Pharmacol 1998; 31: 9-18.
30. Larsen T, Moller G, Bellio R. Evaluation of clinical and clinical chemical parameters in periparturient cows. J Dairy Sci 2001; 84: 1749-58.
31. Moore KW, Waal Malefyt R, Coffman RL, O’Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683-765.
32. Rısvanlı A, Tımurkaan N, Saat N, Dogan H, Seker I. Effect of en bloc ovariohysterectomy on Th1/Th2 cytokine balance and organ histopathology in rats. Med Weter 2017; 73(4): 225-8.
33. Riollet C, Rainard P, and Poutrel B. Differential in-duction of complement fragment C5a and inflam-matory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus. Clin Diagn Lab Immunol 2000; 7: 161-7.
34. Riollet C, Rainard P, Poutrel B. Cell subpopulations and cytokine expression in cow milk in response to chronic Staphylococcus aureus infection. J Dairy Sci 2001; 84: 1077-84.
35. Risvanli A, Doğan H, Şafak T, Öcal H. Memenin sa-vunma sistemi: Meme savunmasında meme başı ve meme başı kanalının rolü. Turkiye Klinikleri J Vet Sci 2019; 5(1): 1-10.
36. Rişvanlı A, Gödekmerdan A. Gebelikte regülatör T-hücreler ve sitokinler. Turkiye Klinikleri J Vet Sci 2011; 2(3): 182-9.
37. Salanga CL, Handel TM. Chemokine oligomerization and interactions with receptors and glycosami-noglycans: the role of structuraldynamics in func-tion. Exp Cell Res 2011; 317: 590-601.
38. Shah C, Hari-Das R, Raynes JG. Serum amyloid A is an innate immune opsonin for Gram-negative bacteria. Blood 2006; 108: 1751-7.
39. Sheldon I, Noakes D, Rycroft A, Dobson H. Acute phase protein responses to uterine bacterial con-tamination in cattle after calving. Vet Rec 2001; 148(6): 172-5.
40. Sheldon IM, Dobson H. Postpartum uterine health in cattle. Anim Reprod Sci 2004; 82: 295-306.
41. Sordillo LM, Contreras GA, Aitken SL. Metabolic fac-tors affecting the inflammatory response of peri-parturient dairy cows. Anim Health Res Rev 2009; 10: 53-63.
42. Toffaletti J, Abrams B. Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood. Clin Chem 1989; 35: 935-8.
43. Través PG, Atauri PD, Marín S, Pimentel-Santillana M, Rodríguez-Prados JC, Marín de Mas I, Selivanov VA, Martín-Sanz P, Boscá L, Cascante M. Relevance of the MEK/ERK sig-naling pathway in the metabolism of activated macrophages: a metabolomic approach. J Immu-nol 2012; 188: 1402-10.
44. Veas F, eds. Acute Phase Proteins as Early Non-Specific Biomarkers of Human and Veterinary Diseases. InTech: US, 2011; pp. 299-354.
45. Zhang G, Dervishi E, Ametaj BN. Milk fever in dairy cows is preceded by activation of innate immunity and alterations in carbohydrate metabolism prior to disease occurrence. Res Vet Sci 2018; 117: 167-77.