Investigation of Paramagnetic Center Formed by Gamma Radiation in Losartan Potassium and Indapamide Drugs Used in Cardiovascular Treatment with EPR Spectroscopy

Year 2018, , 409 - 414, 30.12.2018

Yunus Emre Osmanoğlu

https://doi.org/10.18185/erzifbed.435353

Abstract

In this study, the nature of
free radicals produced in losartan potassium and indapamide was determined
using  electron paramagnetic resonance
(EPR) spectroscopy at room temperature. The EPR spectra of these samples were attributed
to the CHĊHCH₃and ĊHCHCH₃NH radicals, respectively. The
hyperfine coupling constants and g-values of the free radicals were calculated.
EPR measurements show that the stability of the paramagnetic center after
radiation and the spin intensity depend on the dose of absorbed radiation. The
paramagnetic centers in both samples were determined by considering the
chemical structure of the samples. The magnetic properties of the
two materials and the possible structure of the paramagnetic center are
discussed in this study.

Keywords

EPR, Gama-Iradiation, Paramagnetic Centre

Gama Radyasyonunun, Kalp-Damar Tedavisinde Kullanılan Losartan Potasyum ve İndapamid İlaçlarında Oluşturduğu Paramanyetik Merkezin EPR Spektroskopisi ile İncelenmesi

Abstract

Bu
çalışmada, losartan potasyum ve indapamide ilaçlarında gama radyasyonu ile
oluşturulan serbest radikallerin doğası elektron paramanyetik rezonans (EPR)
spektroskopisi kullanılarak oda sıcaklığında belirlenmiştir. Bu örneklerin EPR
spektrumları sırasıyla CHĊHCH₃ ve ĊHCHCH₃NH radikallerine atfedilmiştir. Serbest
radikallerin aşırı ince yapı sabitleri ve g-değerleri hesaplanmıştır. EPR
ölçümleri radyasyondan sonra oluşan paramanyetik merkezin kararlılığı ve spin
yoğunluluğunun absorplanan radyasyonun dozuna bağlı olduğunu göstermiştir. Her
iki örnekte oluşan paramanyetik merkezler örneklerin kimyasal yapısı göz önüne
alınarak belirlenmiştir. İki materyalin manyetik özellikleri ve paramanyetik
merkezin mümkün yapısı bu çalışmada tartışılmıştır.

Keywords

EPR, Gama radyasyonu, Paramanyetik Merkez

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