Investigation of Paramagnetic Center Formed by Gamma Radiation in Losartan Potassium and Indapamide Drugs Used in Cardiovascular Treatment with EPR Spectroscopy

Abstract

In this study, the nature of free radicals produced in losartan potassium and indapamide was determined using  electron paramagnetic resonance (EPR) spectroscopy at room temperature. The EPR spectra of these samples were attributed to the CHĊHCH₃and ĊHCHCH₃NH radicals, respectively. The hyperfine coupling constants and g-values of the free radicals were calculated. EPR measurements show that the stability of the paramagnetic center after radiation and the spin intensity depend on the dose of absorbed radiation. The paramagnetic centers in both samples were determined by considering the chemical structure of the samples. The magnetic properties of the two materials and the possible structure of the paramagnetic center are discussed in this study.

Keywords

• EPR,Gama-Iradiation,Paramagnetic Centre

Gama Radyasyonunun, Kalp-Damar Tedavisinde Kullanılan Losartan Potasyum ve İndapamid İlaçlarında Oluşturduğu Paramanyetik Merkezin EPR Spektroskopisi ile İncelenmesi

Abstract

Bu çalışmada, losartan potasyum ve indapamide ilaçlarında gama radyasyonu ile oluşturulan serbest radikallerin doğası elektron paramanyetik rezonans (EPR) spektroskopisi kullanılarak oda sıcaklığında belirlenmiştir. Bu örneklerin EPR spektrumları sırasıyla CHĊHCH₃ ve ĊHCHCH₃NH radikallerine atfedilmiştir. Serbest radikallerin aşırı ince yapı sabitleri ve g-değerleri hesaplanmıştır. EPR ölçümleri radyasyondan sonra oluşan paramanyetik merkezin kararlılığı ve spin yoğunluluğunun absorplanan radyasyonun dozuna bağlı olduğunu göstermiştir. Her iki örnekte oluşan paramanyetik merkezler örneklerin kimyasal yapısı göz önüne alınarak belirlenmiştir. İki materyalin manyetik özellikleri ve paramanyetik merkezin mümkün yapısı bu çalışmada tartışılmıştır.

Keywords

• EPR,Gama radyasyonu,Paramanyetik Merkez

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