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Investigation of Paramagnetic Center Formed by Gamma Radiation in Losartan Potassium and Indapamide Drugs Used in Cardiovascular Treatment with EPR Spectroscopy

Yıl 2018, , 409 - 414, 30.12.2018
https://doi.org/10.18185/erzifbed.435353

Öz

In this study, the nature of
free radicals produced in losartan potassium and indapamide was determined
using  electron paramagnetic resonance
(EPR) spectroscopy at room temperature. The EPR spectra of these samples were attributed
to the
CHĊHCH3and ĊHCHCH3NH radicals, respectively. The
hyperfine coupling constants and g-values of the free radicals were calculated.
EPR measurements show that the stability of the paramagnetic center after
radiation and the spin intensity depend on the dose of absorbed radiation. The
paramagnetic centers in both samples were determined by considering the
chemical structure of the samples.
The magnetic properties of the
two materials and the possible structure of the paramagnetic center are
discussed in this study.

Kaynakça

  • Ambroż, H.B., Kornacka, E.M., Marciniec, B., Przybytniak, G. 2002. Radical Decay in Irradiated Drugs: Flutamide, Ifosfamide. Journal of Radioanalytical and Nuclear Chemistry, 254(2), 293-298.
  • Atherton, N.M. 1973. Electron Spin Resonance Theory and Application, John-Wiley and sons, NewYork.
  • Aydın, M. 2010. EPR Study of Free Radicals in Amino Acid Derivatives Gamma-Irradiated at 300 K. Indian Journal of Pure and Applied Physic, 48, 611-614.
  • Aydin, M. 2010. Identification of Free Radicals Induced by Gamma Irradiation in Amino Acid Derivatives. Brazilian Journal of Physics, 40(3), 306-308.
  • Basly, J.P. 1999. Radiation Induced Effects on Cephalosporins: An ESR Study. International Journal of Radiation Biology, 75(2), 259-263.
  • Basly, J.P. 1998. Radiation Induced Effects on Cephalosporins: An ESR Study, International Journal of Radiation Biology, 75(2), 259-263. Başkan, M.H., Osmanoğlu, Ş. 2004. EPR of Gamma Irradiated Nα-Monochloroacetyl-α-Aminoisobutyric Acid. Zeitschrift für Naturforschung A, 59(10), 665-668.
  • Bhat, R., Sridhar, K.R. 2011. Influence of Ionizing Radiation and Conventional Food Processing Treatments on the Status of Free Radicals in Lotus Seeds: An ESR Study. Journal of Food Composition and Analysis, 24(4-5), 563-567.
  • Cozar, O., Chis, V., David, L., Damian, G., Barbur, I. 1997. ESR Investigation of Gamma-Irradiated Aspirin. Journal of Radioanalytical and Nuclear Chemistry, 220(2), 241.
  • Damian, G., Schmutzer, G., Petrisor, D., Miclauş, V., Simon, S. 2005. Electron Spin Resonance Studies of γ-Irradiated B3 Vitamin. Romanian Journal of Biophysics, 15(1-4), 23-28.
  • Köksal, F., Osmanoǧlu, Ş., Kartal, I., Ucun, F. 1997. EPR of Gamma Irradiated Nα-Acetyl L-Glutamic Acid and Nα-Acetyl L-Glutamine, Radiation. Physics and Chemistry, 49(5), 537-539.
  • Köksal, F., Osmanoğlu, Ş. 1993. Electron Paramagnetic Resonance of Gamma Irradiation Damage Centres in Ethylenediaminetetraacetic Acid and Diethylenediaminepentaacetic Acids. Journal of Chemical Research, (2), 84-85.
  • Köseoğlu, R., Köseoğlu, E., Köksal, F. 2003. Electron paramagnetic resonance of some γ-irradiated drugs. Applied radiation and Isotopes, 58, 6368.
  • Latosinska, J.N., Pietrzak, J. 2004. EPR Study Of Free Rdicals in Ɣ-İrradiated Thiazide Compounds, Applied Magnetic Resonance, 26(3),345-355.
  • McKelvey, R.D., Huckel, M.O. 1987. Theory and Electron Spin Resonance in the Spectroscopy Course. Journal of Chemical Education, 64, 497. Nakagawa, K., Ikota, N., Sato, Y. 2008. Heavy-Ion-Induced Sucrose and L-α-Alanine Radicals Investigated by EPR. Applied Magnetic Resonance, 33, 111-116.
  • Ogawa, M., Ishıgure, K., Oshima, K. 1980. ESR Study of Irradiated Single Crystals of Amino Acids-1. Radiation Physic and Chemistry, 16, 281-287.
  • Osmanoğlu, Ş. 2017. Investigation of Radiosensitivity of Gamma Irradiated Procaine Hydrochloride in the Solid State. El-Cezeri Journal of Science and Engineering, 4(3), 314-318.
  • Osmanoğlu, Ş. 2016. Radiation Effects on Lamotrigine and Flourbiprofen: an EPR stud. El-Cezeri Journal of Science and Engineering, 3, 281-286.
  • Osmanoğlu, Ş. 2008. Electron Paramagnetic Resonance of Radiation Damage of γ-irradiated Diethylmalonic Acid. Journal of Molecular Structure, 877(1-3), 7-9.
  • Osmanoğlu, Ş., Aydın, M., Başkan, M.H. 2005. EPR of Gamma-Irradiated L-Glutamine Hydrochloride and N-Carbamoyl-L-Glutamic Acid. Zeitschrift für Naturforschung A, 60(7), 549-553.
  • Osmanoğlu, Ş., Başkan, M.H., Güner, T. 2002. EPR of Gamma Irradiated Single Crystal Of 2, 2-Dimethyl Succinic Acid. Zeitschrift für Naturforschung A, 57(11), 909-911.
  • Osmanoğlu, Y.E., Sütçü, K. 2017. EPR Studies of the Free Radicals Generated in Gamma Irradiated Amino Acid Derivatives. Journal of Molecular Structure, 1145, 240-243.
  • Osmanoğlu, Y.E., Sütçü, K., Başkan, M.H. 2017. EPR Investigation of Gamma-Irradiated L-Citrulline, Α-Methyl-Dl-Serine, 3-Fluoro-Dl-Valine and N-Acetyl-L-Cysteine. Journal of Molecular Structure, 1130, 291-295.
  • Peimel-Stuglik, Z., Kowalak, S., Jankowska, A. 2008. EPR Spectra of γ-İrradiated Dl-Α-Alanine Supported on Molecular Sieves. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 69(5), 1395-1404.
  • Poole, C.P., Farach, H.A. 1967. The theory of magnetic resonance, first edition elsevier puplishing company, Amsterdam.
  • Sütçü, K., Osmanoğlu, Y.E. 2017. EPR Study of Gamma-Irradiated N-Methyl-L-Alanine, DL-2-Methyl Glutamic Acid Hemihydrate and Di-Leucine Hydrochloride in Solid State. Journal of Molecular Structure, 1149, 593-595.
  • Sütçü, K., Osmanoğlu, Y. E., Osmanoğlu, Ş. 2014. Effect of Irradiaiton Dose, Microwave Power, and Storage Time on the Free Radical Concentration in γ-Irradiated Black Olive (Olea europaea) Seeds. International Journal of Scientific Research and Innovative Technology, 1(3), 21-29.
  • Talbi, S., Raffi, J., Aréna, S., Colombani, J., Piccerelle, P., Prinderre, P., Dolo, J.M. 2004. EPR Study of Gamma Induced Radicals in Amino Acid Powders. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 60(6), 1335-1341.
  • Wood, D.E., Lloyd, R.V. 1970. EPR of Free Radicals in an Adamantane Matrix. I. Aliphatic Aminoalkyl Radicals. The Journal of Chemical Physics, 53(10), 3932-3942.

Gama Radyasyonunun, Kalp-Damar Tedavisinde Kullanılan Losartan Potasyum ve İndapamid İlaçlarında Oluşturduğu Paramanyetik Merkezin EPR Spektroskopisi ile İncelenmesi

Yıl 2018, , 409 - 414, 30.12.2018
https://doi.org/10.18185/erzifbed.435353

Öz

Bu
çalışmada, losartan potasyum ve indapamide ilaçlarında gama radyasyonu ile
oluşturulan serbest radikallerin doğası elektron paramanyetik rezonans (EPR)
spektroskopisi kullanılarak oda sıcaklığında belirlenmiştir. Bu örneklerin EPR
spektrumları sırasıyla
CHĊHCH3 ve ĊHCHCH3NH radikallerine atfedilmiştir. Serbest
radikallerin aşırı ince yapı sabitleri ve g-değerleri hesaplanmıştır. EPR
ölçümleri radyasyondan sonra oluşan paramanyetik merkezin kararlılığı ve spin
yoğunluluğunun absorplanan radyasyonun dozuna bağlı olduğunu göstermiştir. Her
iki örnekte oluşan paramanyetik merkezler örneklerin kimyasal yapısı göz önüne
alınarak belirlenmiştir. İki materyalin manyetik özellikleri ve paramanyetik
merkezin mümkün yapısı bu çalışmada tartışılmıştır.

Kaynakça

  • Ambroż, H.B., Kornacka, E.M., Marciniec, B., Przybytniak, G. 2002. Radical Decay in Irradiated Drugs: Flutamide, Ifosfamide. Journal of Radioanalytical and Nuclear Chemistry, 254(2), 293-298.
  • Atherton, N.M. 1973. Electron Spin Resonance Theory and Application, John-Wiley and sons, NewYork.
  • Aydın, M. 2010. EPR Study of Free Radicals in Amino Acid Derivatives Gamma-Irradiated at 300 K. Indian Journal of Pure and Applied Physic, 48, 611-614.
  • Aydin, M. 2010. Identification of Free Radicals Induced by Gamma Irradiation in Amino Acid Derivatives. Brazilian Journal of Physics, 40(3), 306-308.
  • Basly, J.P. 1999. Radiation Induced Effects on Cephalosporins: An ESR Study. International Journal of Radiation Biology, 75(2), 259-263.
  • Basly, J.P. 1998. Radiation Induced Effects on Cephalosporins: An ESR Study, International Journal of Radiation Biology, 75(2), 259-263. Başkan, M.H., Osmanoğlu, Ş. 2004. EPR of Gamma Irradiated Nα-Monochloroacetyl-α-Aminoisobutyric Acid. Zeitschrift für Naturforschung A, 59(10), 665-668.
  • Bhat, R., Sridhar, K.R. 2011. Influence of Ionizing Radiation and Conventional Food Processing Treatments on the Status of Free Radicals in Lotus Seeds: An ESR Study. Journal of Food Composition and Analysis, 24(4-5), 563-567.
  • Cozar, O., Chis, V., David, L., Damian, G., Barbur, I. 1997. ESR Investigation of Gamma-Irradiated Aspirin. Journal of Radioanalytical and Nuclear Chemistry, 220(2), 241.
  • Damian, G., Schmutzer, G., Petrisor, D., Miclauş, V., Simon, S. 2005. Electron Spin Resonance Studies of γ-Irradiated B3 Vitamin. Romanian Journal of Biophysics, 15(1-4), 23-28.
  • Köksal, F., Osmanoǧlu, Ş., Kartal, I., Ucun, F. 1997. EPR of Gamma Irradiated Nα-Acetyl L-Glutamic Acid and Nα-Acetyl L-Glutamine, Radiation. Physics and Chemistry, 49(5), 537-539.
  • Köksal, F., Osmanoğlu, Ş. 1993. Electron Paramagnetic Resonance of Gamma Irradiation Damage Centres in Ethylenediaminetetraacetic Acid and Diethylenediaminepentaacetic Acids. Journal of Chemical Research, (2), 84-85.
  • Köseoğlu, R., Köseoğlu, E., Köksal, F. 2003. Electron paramagnetic resonance of some γ-irradiated drugs. Applied radiation and Isotopes, 58, 6368.
  • Latosinska, J.N., Pietrzak, J. 2004. EPR Study Of Free Rdicals in Ɣ-İrradiated Thiazide Compounds, Applied Magnetic Resonance, 26(3),345-355.
  • McKelvey, R.D., Huckel, M.O. 1987. Theory and Electron Spin Resonance in the Spectroscopy Course. Journal of Chemical Education, 64, 497. Nakagawa, K., Ikota, N., Sato, Y. 2008. Heavy-Ion-Induced Sucrose and L-α-Alanine Radicals Investigated by EPR. Applied Magnetic Resonance, 33, 111-116.
  • Ogawa, M., Ishıgure, K., Oshima, K. 1980. ESR Study of Irradiated Single Crystals of Amino Acids-1. Radiation Physic and Chemistry, 16, 281-287.
  • Osmanoğlu, Ş. 2017. Investigation of Radiosensitivity of Gamma Irradiated Procaine Hydrochloride in the Solid State. El-Cezeri Journal of Science and Engineering, 4(3), 314-318.
  • Osmanoğlu, Ş. 2016. Radiation Effects on Lamotrigine and Flourbiprofen: an EPR stud. El-Cezeri Journal of Science and Engineering, 3, 281-286.
  • Osmanoğlu, Ş. 2008. Electron Paramagnetic Resonance of Radiation Damage of γ-irradiated Diethylmalonic Acid. Journal of Molecular Structure, 877(1-3), 7-9.
  • Osmanoğlu, Ş., Aydın, M., Başkan, M.H. 2005. EPR of Gamma-Irradiated L-Glutamine Hydrochloride and N-Carbamoyl-L-Glutamic Acid. Zeitschrift für Naturforschung A, 60(7), 549-553.
  • Osmanoğlu, Ş., Başkan, M.H., Güner, T. 2002. EPR of Gamma Irradiated Single Crystal Of 2, 2-Dimethyl Succinic Acid. Zeitschrift für Naturforschung A, 57(11), 909-911.
  • Osmanoğlu, Y.E., Sütçü, K. 2017. EPR Studies of the Free Radicals Generated in Gamma Irradiated Amino Acid Derivatives. Journal of Molecular Structure, 1145, 240-243.
  • Osmanoğlu, Y.E., Sütçü, K., Başkan, M.H. 2017. EPR Investigation of Gamma-Irradiated L-Citrulline, Α-Methyl-Dl-Serine, 3-Fluoro-Dl-Valine and N-Acetyl-L-Cysteine. Journal of Molecular Structure, 1130, 291-295.
  • Peimel-Stuglik, Z., Kowalak, S., Jankowska, A. 2008. EPR Spectra of γ-İrradiated Dl-Α-Alanine Supported on Molecular Sieves. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 69(5), 1395-1404.
  • Poole, C.P., Farach, H.A. 1967. The theory of magnetic resonance, first edition elsevier puplishing company, Amsterdam.
  • Sütçü, K., Osmanoğlu, Y.E. 2017. EPR Study of Gamma-Irradiated N-Methyl-L-Alanine, DL-2-Methyl Glutamic Acid Hemihydrate and Di-Leucine Hydrochloride in Solid State. Journal of Molecular Structure, 1149, 593-595.
  • Sütçü, K., Osmanoğlu, Y. E., Osmanoğlu, Ş. 2014. Effect of Irradiaiton Dose, Microwave Power, and Storage Time on the Free Radical Concentration in γ-Irradiated Black Olive (Olea europaea) Seeds. International Journal of Scientific Research and Innovative Technology, 1(3), 21-29.
  • Talbi, S., Raffi, J., Aréna, S., Colombani, J., Piccerelle, P., Prinderre, P., Dolo, J.M. 2004. EPR Study of Gamma Induced Radicals in Amino Acid Powders. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 60(6), 1335-1341.
  • Wood, D.E., Lloyd, R.V. 1970. EPR of Free Radicals in an Adamantane Matrix. I. Aliphatic Aminoalkyl Radicals. The Journal of Chemical Physics, 53(10), 3932-3942.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Yunus Emre Osmanoğlu

Yayımlanma Tarihi 30 Aralık 2018
Yayımlandığı Sayı Yıl 2018

Kaynak Göster

APA Osmanoğlu, Y. E. (2018). Gama Radyasyonunun, Kalp-Damar Tedavisinde Kullanılan Losartan Potasyum ve İndapamid İlaçlarında Oluşturduğu Paramanyetik Merkezin EPR Spektroskopisi ile İncelenmesi. Erzincan University Journal of Science and Technology, 11(3), 409-414. https://doi.org/10.18185/erzifbed.435353