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Effect of Tianeptine on Oxidative Renal Damage Induced by Ischemia Reperfusion in Rats

Year 2018, Volume: 11 Issue: 2, 300 - 305, 31.08.2018
https://doi.org/10.18185/erzifbed.422543

Abstract

Renal ischemia-reperfusion (I/R) damage can develop following
major surgical conditions such as shock, trauma, and renal transplantation and
causes acute renal failure. Kidney I/R damage is known to be a pathological
process that begins with the touch free of oxygen and continues with the
production of free oxygen radicals. We will investigate the effect of renal I/R
injury on tianeptine, an atypical antidepressant drug with antioxidant
properties. There was no information on the effect of tianeptine on I/R-induced
kidney damage in the literature.
The aim of the
present study was to
investigate the effect of tianeptine on oxidative kidney
damage induced by I/R in rats. Albino wistar male rats were divided into groups
as renal I/R (RIR) group, 25 mg/kg of thianeptine+renal I/R (TIR-25) group and
sham operation (SG) group. The I/R procedure (one hour ischemia, three hours
reperfusion) was performed with 25 mg/kg intraperitoneal thiopental sodium
anesthesia. Oxidative damage was assessed by malondialdehyde (MDA) and total
glutathione (TGSH) measurements in kidney tissue. Biochemical test results
showed that the I/R process increased the amount of MDA in the kidney tissue
and decreased the tGSH. Tianeptine significantly prevented the increase of MDA
and decrease of tGSH in kidney tissue after I/R. Our experimental results suggest
that tianeptine may be useful in preventing I/R-induced oxidative renal injury.

References

  • Abou, H.H.O., Atef, H., Said, E., Elkashef, H.A., Salem, H.A. 2018. Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity. Environmental Toxicology and Pharmacology, 59(4), 182-189.
  • Alataş, Ö., Şahin, A., Çolak, Ö., Inal, M., Köken, T., Yaşar, B., Karahüseyinğlu, E. 1996. Beneficial effects of allopurinol on glutathione levels and glutathione peroxidase activity in rat ischaemic acute renal failure. Journal of International Medical Research, 24(1), 33-39.
  • Altuner, D., Cetin, N., Suleyman, B., Aslan, Z., Hacimuftuoglu, A., Gulaboglu, M., Suleyman, H. 2013. Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. Indian Journal of Pharmacology, 45(4), 339.
  • András, S. 2008. " Atypical" antidepressive mechanisms: glutamatergic modulation and neuroplasticity in case of tianeptine. Neuropsychopharmacologia Hungarica, 10(5), 305-313.
  • Baron, P., Gomez, M.O., Casas, C., Heil, J., Will, N., Condie, R., Sutherland, D. E. 1991. Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury. Journal of Surgical Research, 51(1), 60-65.
  • Cetin, N., Suleyman, H., Sener, E., Demirci, E., Gundogdu, C., Akcay, F. 2014. The prevention of ischemia/reperfusion induced oxidative damage by venous blood in rabbit kidneys monitored with biochemical, histopatological and immunohistochemical analysis. Journal of Physiology and Pharmacology, 65(3), 383-392.
  • Choucry, M.A., Khalil, M.N.A., El Awdan, S.A. 2018. Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities. Journal of Ethnopharmacology, 214(5), 47-57.
  • Del, R.F.M. 1980. An approach to free radicals in medicine and biology. Acta Physiologica Scandinavica. Supplementum, 492(1), 153-168.
  • Douzinas, E.E., Livaditi, O., Tasoulis, M.K., Prigouris, P., Bakos, D., Goutas, N., Tsoukalas, G.D. 2012. Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation. PLoS One, 7(3), 329-68.
  • Harman, D. 2001. Aging: overview. Annals of the New York Academy of Sciences, 928(1), 1-21.
  • Hermes, L.M., Zenteno, S.T. 2002. Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology Pharmacology, 133(4), 537-556.
  • Karaca, I., Delibas, I.B., Yapca, O.E., Ingec, M., Kumbasar, S., Hirik, E. Bilgin, A.O. 2017. Oxidative Renal Damage in Rats Subjected to Ovarian Ischemia Reperfusion and Protective Effect of Tianeptine. Latin American Journal of Pharmacy, 36(12), 2339-2347.
  • Larson, R.A. 1988. The antioxidants of higher plants. Phytochemistry, 27(4), 969-978.
  • Lien, Y.H.H., Lai, L.W., Silva, A.L. 2003. Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice. Life sciences, 74(5), 543-552.
  • Liu, Z.G., Qi, Z.C., Liu, W.L., Wang, W.Z. 2015. Lutein protects against ischemia/reperfusion injury in rat kidneys. Molecular Medicine Reports, 11(3), 2179-2184.
  • Meister, A., Anderson, M.E. 1983. Glutathione. Annual Review of Biochemistry, 52(1), 711-760.
  • Mitchell, B.J., Russo, A. 1987. The role of glutathione in radiation and drug induced cytotoxicity. The British Journal of Cancer Supplement, 55(8), 96-104.
  • Ohkawa, H., Ohishi, N., Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95(2), 351-358.
  • Reeta, K., Prabhakar, P., Gupta, Y.K. 2016. Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. Behavioural Pharmacology, 27(7), 623-632.
  • Sedlak, J., Lindsay, R.H. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical Biochemistry, 25(1), 192-205.
  • Suleyman, H., Cadirci, E., Albayrak, A., Polat, B., Halici, Z., Koc, F., Bayir, Y. 2009. Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats. Chemico-Biological Interactions, 180(2), 318-324.
  • Şener, G., Tuğtepe, H., Yüksel, M., Çetinel, Ş., Gedik, N., Yeğen, B.Ç. 2006. Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats. Archives of Medical Research, 37(7), 822-829.
  • Torres, G.L., Cienfuegos, P.E., Perales, Q.M.M., Alarcon, G.G., Muñoz, E.L.E., Pérez, R.E., Cordero, P.P. 2018. Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity, Article ID 9572803, 7p.
  • Toyokuni, S. 1999. Reactive oxygen species‐induced molecular damage and its application in pathology. Pathology International, 49(2), 91-102.
  • Young, I., Woodside, J. 2001. Antioxidants in health and disease. Journal of Clinical Pathology, 54(3), 176-186.

Tianeptinin Sıçanlarda İskemi Reperfüzyonla Oluşturulan Oksidatif Böbrek Hasarına Etkisi

Year 2018, Volume: 11 Issue: 2, 300 - 305, 31.08.2018
https://doi.org/10.18185/erzifbed.422543

Abstract

Böbrek iskemi-reperfüzyon (İ/R) hasarı  şok, travma
ve böbrek transplantasyonu gibi majör cerrahi durumları takiben
gelişebilmektedir ve akut böbrek yetmezliğine neden
olmaktadır. Böbrek İ/R hasarının,   dokunun
oksijensiz  kalması ile başlayan ve  serbest oksijen
radikallerinin üretimi ile devam eden patolojik bir süreç olduğu
bilinmektedir. Çalışmamızda böbrek İ/R hasarına etkisini araştıracağımız
tianeptin,  antioksidan özelliğe sahip atipik antidepresan bir
ilaçtır. Literetürlerde tianeptinin, İ/R ile oluşturulan böbrek hasarına
karşı etkisine ait bilgilere rastlanmadı. Çalışmamızın amacı tianeptinin, sıçanlarda İ/R ile oluşturulan
oksidatif böbrek hasarına etkisini araştırmaktır. Albino wistar türü erkek
sıçanlar renal iskemi-reperfüzyon (RİR), 25 mg/kg tianeptin+renal
iskemi-reperfüzyon (TİR-25) ve şam operasyonu uygulanacak (SG)
gruplara  ayrıldı. İ/R işlemi (bir saat iskemi, üç saat reperfüzyon),
25 mg/kg intraperitoneal tiopental sodyum anestezisi uygulanarak yapıldı.
Oksidatif hasar böbrek dokusunda malondialdehid (MDA) ve total glutatyon (tGSH)
ölçümü ile değerlendirildi. Biyokimyasal deney sonuçları, İ/R işleminin böbrek
dokusunda MDA miktarının artmasına tGSH’nın ise azalmasına neden olduğunu
göstermiştir. Tianeptinin, böbrek dokusunda MDA’nın İ/R ile artmasını ve
tGSH’nın azalmasını anlamlı önlediği saptanmıştır. Deney
sonuçlarımız, tianeptinin İ/R ile indüklenen oksidatif böbrek hasarını
önlemede yararlı olabileceğini düşündürmektedir.

References

  • Abou, H.H.O., Atef, H., Said, E., Elkashef, H.A., Salem, H.A. 2018. Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity. Environmental Toxicology and Pharmacology, 59(4), 182-189.
  • Alataş, Ö., Şahin, A., Çolak, Ö., Inal, M., Köken, T., Yaşar, B., Karahüseyinğlu, E. 1996. Beneficial effects of allopurinol on glutathione levels and glutathione peroxidase activity in rat ischaemic acute renal failure. Journal of International Medical Research, 24(1), 33-39.
  • Altuner, D., Cetin, N., Suleyman, B., Aslan, Z., Hacimuftuoglu, A., Gulaboglu, M., Suleyman, H. 2013. Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. Indian Journal of Pharmacology, 45(4), 339.
  • András, S. 2008. " Atypical" antidepressive mechanisms: glutamatergic modulation and neuroplasticity in case of tianeptine. Neuropsychopharmacologia Hungarica, 10(5), 305-313.
  • Baron, P., Gomez, M.O., Casas, C., Heil, J., Will, N., Condie, R., Sutherland, D. E. 1991. Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury. Journal of Surgical Research, 51(1), 60-65.
  • Cetin, N., Suleyman, H., Sener, E., Demirci, E., Gundogdu, C., Akcay, F. 2014. The prevention of ischemia/reperfusion induced oxidative damage by venous blood in rabbit kidneys monitored with biochemical, histopatological and immunohistochemical analysis. Journal of Physiology and Pharmacology, 65(3), 383-392.
  • Choucry, M.A., Khalil, M.N.A., El Awdan, S.A. 2018. Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities. Journal of Ethnopharmacology, 214(5), 47-57.
  • Del, R.F.M. 1980. An approach to free radicals in medicine and biology. Acta Physiologica Scandinavica. Supplementum, 492(1), 153-168.
  • Douzinas, E.E., Livaditi, O., Tasoulis, M.K., Prigouris, P., Bakos, D., Goutas, N., Tsoukalas, G.D. 2012. Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation. PLoS One, 7(3), 329-68.
  • Harman, D. 2001. Aging: overview. Annals of the New York Academy of Sciences, 928(1), 1-21.
  • Hermes, L.M., Zenteno, S.T. 2002. Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology Pharmacology, 133(4), 537-556.
  • Karaca, I., Delibas, I.B., Yapca, O.E., Ingec, M., Kumbasar, S., Hirik, E. Bilgin, A.O. 2017. Oxidative Renal Damage in Rats Subjected to Ovarian Ischemia Reperfusion and Protective Effect of Tianeptine. Latin American Journal of Pharmacy, 36(12), 2339-2347.
  • Larson, R.A. 1988. The antioxidants of higher plants. Phytochemistry, 27(4), 969-978.
  • Lien, Y.H.H., Lai, L.W., Silva, A.L. 2003. Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice. Life sciences, 74(5), 543-552.
  • Liu, Z.G., Qi, Z.C., Liu, W.L., Wang, W.Z. 2015. Lutein protects against ischemia/reperfusion injury in rat kidneys. Molecular Medicine Reports, 11(3), 2179-2184.
  • Meister, A., Anderson, M.E. 1983. Glutathione. Annual Review of Biochemistry, 52(1), 711-760.
  • Mitchell, B.J., Russo, A. 1987. The role of glutathione in radiation and drug induced cytotoxicity. The British Journal of Cancer Supplement, 55(8), 96-104.
  • Ohkawa, H., Ohishi, N., Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95(2), 351-358.
  • Reeta, K., Prabhakar, P., Gupta, Y.K. 2016. Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. Behavioural Pharmacology, 27(7), 623-632.
  • Sedlak, J., Lindsay, R.H. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical Biochemistry, 25(1), 192-205.
  • Suleyman, H., Cadirci, E., Albayrak, A., Polat, B., Halici, Z., Koc, F., Bayir, Y. 2009. Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats. Chemico-Biological Interactions, 180(2), 318-324.
  • Şener, G., Tuğtepe, H., Yüksel, M., Çetinel, Ş., Gedik, N., Yeğen, B.Ç. 2006. Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats. Archives of Medical Research, 37(7), 822-829.
  • Torres, G.L., Cienfuegos, P.E., Perales, Q.M.M., Alarcon, G.G., Muñoz, E.L.E., Pérez, R.E., Cordero, P.P. 2018. Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity, Article ID 9572803, 7p.
  • Toyokuni, S. 1999. Reactive oxygen species‐induced molecular damage and its application in pathology. Pathology International, 49(2), 91-102.
  • Young, I., Woodside, J. 2001. Antioxidants in health and disease. Journal of Clinical Pathology, 54(3), 176-186.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Makaleler
Authors

Bahadir Süleyman

Aslı Özbek Bilgin

Renad Mammadov

Publication Date August 31, 2018
Published in Issue Year 2018 Volume: 11 Issue: 2

Cite

APA Süleyman, B., Özbek Bilgin, A., & Mammadov, R. (2018). Tianeptinin Sıçanlarda İskemi Reperfüzyonla Oluşturulan Oksidatif Böbrek Hasarına Etkisi. Erzincan University Journal of Science and Technology, 11(2), 300-305. https://doi.org/10.18185/erzifbed.422543