PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ

Abstract

Bu çift kör, randomize, plasebo kontrollü klinik çalışmada, Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastillerin tükürük akış hızı, miktarı, kıvamı, pH’ı ve tamponlama kapasitesi üzerine etkileri incelenmiştir. Çalışmaya, 8-13 yaş arası 40 çocuk katılmış ve katılımcılar çift kör randomize yöntemiyle tedavi ve plasebo gruplarına ayrılmıştır. Tedavi grubuna 56 gün boyunca Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastil verilmiş, plasebo grubu ise aynı süre boyunca plasebo pastil kullanmıştır. Tükürük akış hızı, kıvamı, pH değeri ve tamponlama kapasitesi başlangıçta ve 56. günde Saliva-Check BUFFER kiti kullanılarak ölçülmüştür. Tanımlayıcı istatistiklerin yanı sıra bağımsız ve eşleştirilmiş örneklem t-testi, Ki-kare testi ve Mc Nemar testi kullanılarak analiz yapılmıştır. İstatistiksel anlamlılık düzeyi olarak p<0.05 kabul edilmiştir. Bulgular, 56 gün sonunda tedavi grubunda plasebo grubuna göre tükürük akış hızı ve pH'ın da istatistiksel olarak anlamlı bir artış olduğunu göstermiştir (p<0.05). Tükürük tamponlama kapasitesi, miktarı ve kıvamı açısından ise 56 gün sonunda anlamlı bir fark bulunamamıştır (p>0.05). Sonuçlar, çocuklarda Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastilin ağız sağlığını destekleme potansiyeline sahip olabileceğine işaret etmektedir

Keywords

• : Kazein fosfopeptid-amorf kalsiyum fosfat
• probiyotikler
• tükürük

CLINICAL EVALUATION OF THE EFFECTS OF A PROBIOTIC LOZENGE ON CHILDREN'S SALIVARY PARAMETERS

Abstract

This double-blind, randomized, placebo-controlled clinical trial aimed to evaluate the effects of Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges on various salivary parameters, including flow rate, volume, consistency, pH, and buffering capacity. A total of 40 children, aged 8-13, participated in the study and were randomly assigned to either the treatment or placebo group. The treatment group received Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges for 56 days, while the placebo group received placebo lozenges without active ingredients. Salivary flow rate, consistency, pH, and buffering capacity were assessed using the Saliva-Check BUFFER kit at baseline and after 56 days. Descriptive statistics, independent and paired t-tests, Chi-square tests, and Mc Nemar tests were employed for analysis, with statistical significance set at p<0.05. Results indicated a statistically significant increase in both salivary flow rate and pH in the treatment group compared to the placebo group at the end of 56 days (p<0.05). However, no significant changes were observed in buffering capacity, volume, or consistency between the two groups (p>0.05). These findings suggest that Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges may have potential in supporting oral health in children.

Keywords

• Casein phosphopeptide-amorphous calcium phosphate
• probiotics
• saliva

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