Relationship Between B-Type Natriuretic Peptide Levels With Some Blood Parameters in Diarrheic Calves

Abstract

This study aimed to determine the relationship of plasma B-type natriuretic peptide levels with hematological and some serum biochemical parameters (serum creatinine, sodium, potassium, and total protein levels) in healthy and neonatal diarrhea calves. The material of the study was consisted of newborn calves with 44 diarrheic and 40 healthy, which were brought to Erciyes University Veterinary Faculty Training, Research and Application Hospital Internal Medicine Clinics for diagnosis, treatment and control purposes. Blood and serum samples were taken from the calves included in the study. Hematological parameters, plasma B-type natriuretic peptide, serum creatinine, sodium, potassium and total protein levels were determined from the samples taken. There was no statistically significant difference in plasma B-type natriuretic peptide levels between diarrheic and healthy groups (p>0.05). However, the Cohen’s d effect size to determine clinical significance was calculated as 0.228. This result indicated that an average of 53 units (1259-1206) lower plasma B-type natriuretic peptide value in the diarrheal group could be considered clinically significant. In addition, a statistically significant difference was found between the diarrheal and healthy groups in creatinine, Na, to tally leukocytes, neutrophils and mean platelet volume parameters (p<0.05). The only effective variable on plasma B-type natriuretic peptide was determined as creatine. As a result, it was determined that the plasma B-type natriuretic peptide level in calves with diarrhea was lower than the healthy ones and there was a correlation between the plasma B-type natriuretic peptide levels and the serum creatinine levels.

Keywords

• Biochemistry
• B-type natriuretic peptide
• calf
• calf diarrhea
• hematology

İshalli Buzağılarda B-Tipi Natriüretik Peptit Seviyeleri ve Bazı Kan Parametreleri Arasındaki İlişki*

Abstract

Bu çalışmanın amacı neonatal ishalli ve sağlıklı buzağılarda plazma B-tipi natriüretik peptit seviyeleri ile hematolojik ve bazı serum biyokimyasal parametreleri (serum kreatinin, sodyum, potasyum ve total protein seviyeleri) arasındaki ilişkinin belirlenmesidir. Çalışma materyalini Erciyes Üniversitesi Veteriner Fakültesi Eğitim Araştırma Uygulama Hastanesi İç Hastalıkları Anabilim Dalı Kliniğine teşhis, tedavi ve kontrol amacı ile getirilen 44 adet ishalli ve 40 adet sağlıklı yeni doğan buzağı oluşturdu. Çalışmaya dâhil edilen buzağılardan alınan tam kan ve serum örneklerinde hematolojik parametreler ile biyokimyasal parametreler belirlendi. İshalli ve sağlıklı gruplar arasında plazma B-tipi natriüretik peptit düzeyi bakımından istatistiksel olarak anlamlı farklılık bulunmadı (p>0.05). Ancak klinik anlamlılığın tespiti amacıyla Cohen d etki büyüklüğü 0.228 olarak hesaplandı. Bu durum ishalli grupta plazma B-tipi natriüretik peptit değerinin ortalama 53 birim (1259-1206) az olmasının klinik olarak anlamlı kabul edilebileceğini gösterdi. Ayrıca çalışmada ishalli ve sağlıklı gruplar arasında kreatinin, Na, lökosit, nötrofil ve ortalama platelet hacmi değişkenleri bakımından istatistiksel olarak anlamlı farklılık bulundu (p<0.05). Plazma B-tipi natriüretik peptit üzerine tek etkili değişken kreatinin olarak belirlendi. Sonuç olarak, ishalli buzağılarda plazma B-tipi natriüretik peptit seviyesinin sağlıklılara göre düşük olduğu ve plazma B-tipi natriüretik peptit düzeyi ile serum kreatinin seviyesi arasında negatif korelasyon olduğu belirlendi.

Keywords

• Biyokimya
• B-tip natriüretik peptid
• buzağı
• buzağı ishalleri
• hematoloji

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