KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA FENOTİPLERE GÖRE KAN BİYOBELİRTEÇLERİNİN KARŞILAŞTIRILMASI

Abstract

Amaç: Kronik obstrüktif akciğer hastalığı (KOAH)'nda hava yolu inflamasyonu, biyobelirteçler kullanılarak ölçülebilir. Bu çalışma, sistemik inflamasyonun biyobelirteçlerini kullanarak KOAH'ın heterojenliğini araştırmak için yapılmıştır.

Gereç ve Yöntem: 19 KOAH'lı hastanın toraks bilgisayar tomografisi amfizem baskın ve kronik bronşit baskın olmasına göre değerlendirildi ve kan biyobelirteçleriyle karşılaştırıldı.

Bulgular: Çalışma grubunun yaş ortalaması 72,1±8,0 yıldı. KOAH fenotipiyle kan biyobelirteçleri arasında bir fark saptanmazken, amfizem baskın ile kronik bronşit arasında, toraks anteroposterior (AP) ve transvers çap açısından istatistiksel olarak anlamlı fark saptanmıştır. AP çap/transvers çap oranı ile TNF-alfa arasında pozitif yönlü güçlü istatistiksel olarak anlamlı korelasyon saptandı.

Sonuç: Yaygın kronik bronşitli hastalar ile yaygın pulmoner amfizemi olan hastalar arasında inflamatuar biyobelirteçler açısından anlamlı fark bulunmaması, bu iki klinik ve fonksiyonel fenotipin benzer inflamatuar bir paterne sahip olabileceğini düşündürmüştür. Sonuç olarak, KOAH'ın fenotipik ayrımı ya da tedaviye yanıtın değerlendirilmesi için biyobelirteçlerin kullanımına büyük bir ilgi vardır. Sonuçlarımızın, daha büyük klinik çalışmaların planlanmasında fayda sağlayacağını düşünüyoruz.

Keywords

• KOAH,Fenotipler,Biyomarkırlar

COMPARISON OF BLOOD BIOMARKERS WITH PHENOTYPES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Purpose: Airway inflammation in chronic obstructive pulmonary disease (COPD) can be measured using biomarkers. This study was conducted to investigate the heterogeneity of COPD using biomarkers of systemic inflammation.

Materials and Methods: Thirty-six patients with COPD had thoracic computer tomography assessed as predominantly emphysematous and chronic bronchitis predominance and compared with blood biomarkers.

Results: The mean age of the study group was 72,1±8,0 years. There was a statistically significant difference between AP and transverse diameter between emphysema predominant and chronic bronchitis. There was a positive statistically significant correlation between thorax anteroposterior (AP) diameter and transverse diameter ratio and TNF-alpha, while no difference was found between COPD phenotype and blood biomarkers.

Conclusion: The absence of a significant difference in inflammatory biomarkers between patients with diffuse chronic bronchitis and those with diffuse pulmonary emphysema suggests that these two clinical and functional phenotypes may have a similar inflammatory pattern. In conclusion, there is great interest in the use of biomarkers for assessing phenotypic discrimination or response to COPD. We think that our results will be beneficial in planning larger clinical trials.

Keywords

• COPD,Phenotypes,Biomarkers

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